Comparative angiotensin II receptor blockade in healthy volunteers: The importance of dosing

Objectives We have reported previously that 80 mg valsartan and 50 mg losartan provide less receptor blockade than 150 mg irbesartan in normotensive subjects. In this study we investigated the importance of drug dosing in mediating these differences by comparing the AT1‐receptor blockade induced by...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2002-01, Vol.71 (1), p.68-76
Hauptverfasser:	Maillard, Marc P., Würzner, Grégoire, Nussberger, Jürg, Centeno, Catherine, Burnier, Michel, Brunner, Hans R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiotensin II - metabolism Angiotensin Receptor Antagonists Antihypertensive agents Antihypertensive Agents - administration & dosage Antihypertensive Agents - pharmacokinetics Antihypertensive Agents - pharmacology Benzimidazoles - pharmacology Biological and medical sciences Biphenyl Compounds - pharmacology Cardiovascular system Cross-Over Studies Dose-Response Relationship, Drug Humans Losartan - administration & dosage Losartan - pharmacokinetics Losartan - pharmacology Male Medical sciences Pharmacology. Drug treatments Renin - blood Renin-Angiotensin System - drug effects Tetrazoles - administration & dosage Tetrazoles - pharmacokinetics Tetrazoles - pharmacology Valine - administration & dosage Valine - analogs & derivatives Valine - pharmacokinetics Valine - pharmacology Valsartan
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