Expression of Drosophila Trehalose-Phosphate Synthase in HEK-293 Cells Increases Hypoxia Tolerance

Increasing hypoxia tolerance in mammalian cells is potentially of major importance, but it has not been feasible thus far. The disaccharide trehalose, which accumulates dramatically during heat shock, enhances thermotolerance and reduces aggregation of denatured proteins. Previous studies from our l...

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Veröffentlicht in:	The Journal of biological chemistry 2003-12, Vol.278 (49), p.49113-49118
Hauptverfasser:	Chen, Qiaofang, Behar, Kevin L., Xu, Tian, Fan, Chenhao, Haddad, Gabriel G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - physiology Animals Cell Hypoxia - physiology Cloning, Molecular Drosophila Drosophila melanogaster dtps1 gene Glucose - metabolism Glucosyltransferases - genetics Glucosyltransferases - metabolism Glucosyltransferases - physiology Humans Sodium-Potassium-Exchanging ATPase - metabolism Trehalose - metabolism trehalose-phosphate synthase
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