MAPK-regulated transcription: a continuously variable gene switch?

Switching mechanisms that control genes could be viewed either as stable binary switches, in which genes exist in 'on' or 'off' states; or as quantitative rheostat-like switches, in which the rate of transcription is continuously variable and coupled directly to the strength of i...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2002-01, Vol.3 (1), p.30-40
Hauptverfasser:	Hazzalin, Catherine A, Mahadevan, Louis C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biochemistry Chromatin - metabolism Enzymes Gene Silencing Genes Immediate-Early Proteins - biosynthesis Immediate-Early Proteins - genetics Kinases MAP Kinase Signaling System Mitogen-Activated Protein Kinases - physiology Models, Genetic Phosphorylation Proteins Regulatory Sequences, Nucleic Acid Transcription factors Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation
Online-Zugang:	Volltext
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