Early gastric carcinoma with signet ring cell histology
BACKGROUND There has been much controversy surrounding the biologic behavior and prognosis of early stage gastric signet ring cell carcinoma (SRC). To clarify the biologic behavior of early stage gastric SRC (early SRC), we compared the clinicopathologic features and prognosis of early SRC with othe...
Gespeichert in:
| Veröffentlicht in: | Cancer 2002-01, Vol.94 (1), p.78-83 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 83 |
|---|---|
| container_issue | 1 |
| container_start_page | 78 |
| container_title | Cancer |
| container_volume | 94 |
| creator | Hyung, Woo Jin Noh, Sung Hoon Lee, Jun Ho Huh, Jihun J. Lah, Ki Hyeok Choi, Seung Ho Min, Jin Sik |
| description | BACKGROUND
There has been much controversy surrounding the biologic behavior and prognosis of early stage gastric signet ring cell carcinoma (SRC). To clarify the biologic behavior of early stage gastric SRC (early SRC), we compared the clinicopathologic features and prognosis of early SRC with other histologic types.
METHODS
A total of 933 patients with early gastric carcinoma who had undergone gastrectomy from 1987 to 1995 were retrospectively analyzed. Among them, 263 patients with SRC were compared to 670 patients with other histologic types.
RESULTS
Younger patients more often had SRC than non‐SRC. Additionally, the proportion of females was greater in SRC than in non‐SRC. Signet ring cell carcinoma had a larger proportion of mucosa‐confined lesions and a lower rate of lymph node metastasis than non‐SRC. Even after stratifying the clinicopathologic characteristics, SRC showed a lower rate of lymph node metastasis than non‐SRC. When the lymph node metastasis rate was compared between SRC and undifferentiated histology other than SRC, SRC demonstrated a lower lymph node metastasis rate. Multivariate analysis showed that SRC histology was a negative independent risk factor for lymph node metastasis in early gastric carcinoma. The prognosis of SRC was significantly better than that of non‐SRC (P = 0.0104).
CONCLUSIONS
Early gastric carcinoma with SRC is a distinct type of gastric carcinoma in terms of clinicopathologic features and prognosis. The favorable prognosis and lower rate of lymph node metastasis in early SRC suggest that the patients with early gastric carcinoma with SRC could be candidates for less invasive surgeries for an improved quality of life. Cancer 2002;94:78–83. © 2002 American Cancer Society.
A retrospective study of 933 patients who had undergone gastrectomy for early gastric carcinoma revealed that early gastric carcinoma with signet ring cell histology had a lower rate of lymph node metastasis and more favorable prognosis. Early gastric carcinoma with signet ring cell histology could be managed by less invasive surgery. |
| doi_str_mv | 10.1002/cncr.10120 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71420681</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71420681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3550-59e9073ad42857e0a036fa4fcc0ec99068f442829fc06563fcbdaa3931a0c773</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlYv_gDZix6E1clms2mOstQPKArSg7eQpsk2sh812VL235t1F3rzNDPMwzvvvAhdY3jAAMmjqpULHU7gBE0xcBYDTpNTNAWAeUxT8jVBF95_h5EllJyjCcZzTHmWTBFbSFd2USF966yKlHTK1k0lo4Ntt5G3Ra3byNm6iJQuy2hrfduUTdFdojMjS6-vxjpDq-fFKn-Nlx8vb_nTMlaEUogp1xwYkZs0mVOmQQLJjEyNUqAV55DNTRpWCTcKMpoRo9YbKQknWIJijMzQ3SC7c83PXvtWVNb3TmStm70XLDwaRHAA7wdQucZ7p43YOVtJ1wkMok9J9CmJv5QCfDOq7teV3hzRMZYA3I6A9EqWxslaWX_kSEogg94eHriDLXX3z0mRv-efw_FfZTJ96A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71420681</pqid></control><display><type>article</type><title>Early gastric carcinoma with signet ring cell histology</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Hyung, Woo Jin ; Noh, Sung Hoon ; Lee, Jun Ho ; Huh, Jihun J. ; Lah, Ki Hyeok ; Choi, Seung Ho ; Min, Jin Sik</creator><creatorcontrib>Hyung, Woo Jin ; Noh, Sung Hoon ; Lee, Jun Ho ; Huh, Jihun J. ; Lah, Ki Hyeok ; Choi, Seung Ho ; Min, Jin Sik</creatorcontrib><description>BACKGROUND
There has been much controversy surrounding the biologic behavior and prognosis of early stage gastric signet ring cell carcinoma (SRC). To clarify the biologic behavior of early stage gastric SRC (early SRC), we compared the clinicopathologic features and prognosis of early SRC with other histologic types.
METHODS
A total of 933 patients with early gastric carcinoma who had undergone gastrectomy from 1987 to 1995 were retrospectively analyzed. Among them, 263 patients with SRC were compared to 670 patients with other histologic types.
RESULTS
Younger patients more often had SRC than non‐SRC. Additionally, the proportion of females was greater in SRC than in non‐SRC. Signet ring cell carcinoma had a larger proportion of mucosa‐confined lesions and a lower rate of lymph node metastasis than non‐SRC. Even after stratifying the clinicopathologic characteristics, SRC showed a lower rate of lymph node metastasis than non‐SRC. When the lymph node metastasis rate was compared between SRC and undifferentiated histology other than SRC, SRC demonstrated a lower lymph node metastasis rate. Multivariate analysis showed that SRC histology was a negative independent risk factor for lymph node metastasis in early gastric carcinoma. The prognosis of SRC was significantly better than that of non‐SRC (P = 0.0104).
CONCLUSIONS
Early gastric carcinoma with SRC is a distinct type of gastric carcinoma in terms of clinicopathologic features and prognosis. The favorable prognosis and lower rate of lymph node metastasis in early SRC suggest that the patients with early gastric carcinoma with SRC could be candidates for less invasive surgeries for an improved quality of life. Cancer 2002;94:78–83. © 2002 American Cancer Society.
A retrospective study of 933 patients who had undergone gastrectomy for early gastric carcinoma revealed that early gastric carcinoma with signet ring cell histology had a lower rate of lymph node metastasis and more favorable prognosis. Early gastric carcinoma with signet ring cell histology could be managed by less invasive surgery.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.10120</identifier><identifier>PMID: 11815962</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Biological and medical sciences ; Carcinoma, Signet Ring Cell - pathology ; Carcinoma, Signet Ring Cell - surgery ; clinicopathologic feature ; early gastric carcinoma ; Female ; Gastrectomy ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Prognosis ; Retrospective Studies ; signet ring cell carcinoma ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Analysis ; Tumors</subject><ispartof>Cancer, 2002-01, Vol.94 (1), p.78-83</ispartof><rights>Copyright © 2002 American Cancer Society</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 American Cancer Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3550-59e9073ad42857e0a036fa4fcc0ec99068f442829fc06563fcbdaa3931a0c773</citedby><cites>FETCH-LOGICAL-c3550-59e9073ad42857e0a036fa4fcc0ec99068f442829fc06563fcbdaa3931a0c773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.10120$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.10120$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,4010,27900,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13430607$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11815962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hyung, Woo Jin</creatorcontrib><creatorcontrib>Noh, Sung Hoon</creatorcontrib><creatorcontrib>Lee, Jun Ho</creatorcontrib><creatorcontrib>Huh, Jihun J.</creatorcontrib><creatorcontrib>Lah, Ki Hyeok</creatorcontrib><creatorcontrib>Choi, Seung Ho</creatorcontrib><creatorcontrib>Min, Jin Sik</creatorcontrib><title>Early gastric carcinoma with signet ring cell histology</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
There has been much controversy surrounding the biologic behavior and prognosis of early stage gastric signet ring cell carcinoma (SRC). To clarify the biologic behavior of early stage gastric SRC (early SRC), we compared the clinicopathologic features and prognosis of early SRC with other histologic types.
METHODS
A total of 933 patients with early gastric carcinoma who had undergone gastrectomy from 1987 to 1995 were retrospectively analyzed. Among them, 263 patients with SRC were compared to 670 patients with other histologic types.
RESULTS
Younger patients more often had SRC than non‐SRC. Additionally, the proportion of females was greater in SRC than in non‐SRC. Signet ring cell carcinoma had a larger proportion of mucosa‐confined lesions and a lower rate of lymph node metastasis than non‐SRC. Even after stratifying the clinicopathologic characteristics, SRC showed a lower rate of lymph node metastasis than non‐SRC. When the lymph node metastasis rate was compared between SRC and undifferentiated histology other than SRC, SRC demonstrated a lower lymph node metastasis rate. Multivariate analysis showed that SRC histology was a negative independent risk factor for lymph node metastasis in early gastric carcinoma. The prognosis of SRC was significantly better than that of non‐SRC (P = 0.0104).
CONCLUSIONS
Early gastric carcinoma with SRC is a distinct type of gastric carcinoma in terms of clinicopathologic features and prognosis. The favorable prognosis and lower rate of lymph node metastasis in early SRC suggest that the patients with early gastric carcinoma with SRC could be candidates for less invasive surgeries for an improved quality of life. Cancer 2002;94:78–83. © 2002 American Cancer Society.
A retrospective study of 933 patients who had undergone gastrectomy for early gastric carcinoma revealed that early gastric carcinoma with signet ring cell histology had a lower rate of lymph node metastasis and more favorable prognosis. Early gastric carcinoma with signet ring cell histology could be managed by less invasive surgery.</description><subject>Biological and medical sciences</subject><subject>Carcinoma, Signet Ring Cell - pathology</subject><subject>Carcinoma, Signet Ring Cell - surgery</subject><subject>clinicopathologic feature</subject><subject>early gastric carcinoma</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>signet ring cell carcinoma</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlYv_gDZix6E1clms2mOstQPKArSg7eQpsk2sh812VL235t1F3rzNDPMwzvvvAhdY3jAAMmjqpULHU7gBE0xcBYDTpNTNAWAeUxT8jVBF95_h5EllJyjCcZzTHmWTBFbSFd2USF966yKlHTK1k0lo4Ntt5G3Ra3byNm6iJQuy2hrfduUTdFdojMjS6-vxjpDq-fFKn-Nlx8vb_nTMlaEUogp1xwYkZs0mVOmQQLJjEyNUqAV55DNTRpWCTcKMpoRo9YbKQknWIJijMzQ3SC7c83PXvtWVNb3TmStm70XLDwaRHAA7wdQucZ7p43YOVtJ1wkMok9J9CmJv5QCfDOq7teV3hzRMZYA3I6A9EqWxslaWX_kSEogg94eHriDLXX3z0mRv-efw_FfZTJ96A</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Hyung, Woo Jin</creator><creator>Noh, Sung Hoon</creator><creator>Lee, Jun Ho</creator><creator>Huh, Jihun J.</creator><creator>Lah, Ki Hyeok</creator><creator>Choi, Seung Ho</creator><creator>Min, Jin Sik</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Early gastric carcinoma with signet ring cell histology</title><author>Hyung, Woo Jin ; Noh, Sung Hoon ; Lee, Jun Ho ; Huh, Jihun J. ; Lah, Ki Hyeok ; Choi, Seung Ho ; Min, Jin Sik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3550-59e9073ad42857e0a036fa4fcc0ec99068f442829fc06563fcbdaa3931a0c773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma, Signet Ring Cell - pathology</topic><topic>Carcinoma, Signet Ring Cell - surgery</topic><topic>clinicopathologic feature</topic><topic>early gastric carcinoma</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>signet ring cell carcinoma</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hyung, Woo Jin</creatorcontrib><creatorcontrib>Noh, Sung Hoon</creatorcontrib><creatorcontrib>Lee, Jun Ho</creatorcontrib><creatorcontrib>Huh, Jihun J.</creatorcontrib><creatorcontrib>Lah, Ki Hyeok</creatorcontrib><creatorcontrib>Choi, Seung Ho</creatorcontrib><creatorcontrib>Min, Jin Sik</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hyung, Woo Jin</au><au>Noh, Sung Hoon</au><au>Lee, Jun Ho</au><au>Huh, Jihun J.</au><au>Lah, Ki Hyeok</au><au>Choi, Seung Ho</au><au>Min, Jin Sik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early gastric carcinoma with signet ring cell histology</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>94</volume><issue>1</issue><spage>78</spage><epage>83</epage><pages>78-83</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
There has been much controversy surrounding the biologic behavior and prognosis of early stage gastric signet ring cell carcinoma (SRC). To clarify the biologic behavior of early stage gastric SRC (early SRC), we compared the clinicopathologic features and prognosis of early SRC with other histologic types.
METHODS
A total of 933 patients with early gastric carcinoma who had undergone gastrectomy from 1987 to 1995 were retrospectively analyzed. Among them, 263 patients with SRC were compared to 670 patients with other histologic types.
RESULTS
Younger patients more often had SRC than non‐SRC. Additionally, the proportion of females was greater in SRC than in non‐SRC. Signet ring cell carcinoma had a larger proportion of mucosa‐confined lesions and a lower rate of lymph node metastasis than non‐SRC. Even after stratifying the clinicopathologic characteristics, SRC showed a lower rate of lymph node metastasis than non‐SRC. When the lymph node metastasis rate was compared between SRC and undifferentiated histology other than SRC, SRC demonstrated a lower lymph node metastasis rate. Multivariate analysis showed that SRC histology was a negative independent risk factor for lymph node metastasis in early gastric carcinoma. The prognosis of SRC was significantly better than that of non‐SRC (P = 0.0104).
CONCLUSIONS
Early gastric carcinoma with SRC is a distinct type of gastric carcinoma in terms of clinicopathologic features and prognosis. The favorable prognosis and lower rate of lymph node metastasis in early SRC suggest that the patients with early gastric carcinoma with SRC could be candidates for less invasive surgeries for an improved quality of life. Cancer 2002;94:78–83. © 2002 American Cancer Society.
A retrospective study of 933 patients who had undergone gastrectomy for early gastric carcinoma revealed that early gastric carcinoma with signet ring cell histology had a lower rate of lymph node metastasis and more favorable prognosis. Early gastric carcinoma with signet ring cell histology could be managed by less invasive surgery.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11815962</pmid><doi>10.1002/cncr.10120</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 2002-01, Vol.94 (1), p.78-83 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71420681 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Carcinoma, Signet Ring Cell - pathology Carcinoma, Signet Ring Cell - surgery clinicopathologic feature early gastric carcinoma Female Gastrectomy Gastroenterology. Liver. Pancreas. Abdomen Humans Lymphatic Metastasis Male Medical sciences Middle Aged Prognosis Retrospective Studies signet ring cell carcinoma Stomach Neoplasms - pathology Stomach Neoplasms - surgery Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors |
| title | Early gastric carcinoma with signet ring cell histology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T05%3A05%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20gastric%20carcinoma%20with%20signet%20ring%20cell%20histology&rft.jtitle=Cancer&rft.au=Hyung,%20Woo%20Jin&rft.date=2002-01-01&rft.volume=94&rft.issue=1&rft.spage=78&rft.epage=83&rft.pages=78-83&rft.issn=0008-543X&rft.eissn=1097-0142&rft.coden=CANCAR&rft_id=info:doi/10.1002/cncr.10120&rft_dat=%3Cproquest_cross%3E71420681%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71420681&rft_id=info:pmid/11815962&rfr_iscdi=true |