The multifaceted adult epidermal stem cell
Adult epidermal stem cells renew the epithelial compartment of the skin throughout life and are the most accessible of all adult stem cells. Most importantly, epidermal stem cells can be efficiently cultivated and transplanted, a significant advantage for cell and gene therapy. Recent work has point...
Gespeichert in:
| Veröffentlicht in: | Current opinion in cell biology 2003-12, Vol.15 (6), p.771-777 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 777 |
|---|---|
| container_issue | 6 |
| container_start_page | 771 |
| container_title | Current opinion in cell biology |
| container_volume | 15 |
| creator | Gambardella, Laure Barrandon, Yann |
| description | Adult epidermal stem cells renew the epithelial compartment of the skin throughout life and are the most accessible of all adult stem cells. Most importantly, epidermal stem cells can be efficiently cultivated and transplanted, a significant advantage for cell and gene therapy. Recent work has pointed to the hair follicle as the main repository of multipotent stem cells in skin. Hair follicles, which are often affected in the mouse by spontaneous or man-made mutations, have become superb model systems to study the cellular and molecular factors that regulate the proliferation, migration and fate of adult stem cells. |
| doi_str_mv | 10.1016/j.ceb.2003.10.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71420118</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0955067403001388</els_id><sourcerecordid>71420118</sourcerecordid><originalsourceid>FETCH-LOGICAL-c349t-f18eb6dcf1e7c5caf50d50822002b82c424865b5a568584acad5cadd5bfbc0ba3</originalsourceid><addsrcrecordid>eNp9kM1LxDAQxYMo7rr6B3iRnjwIrZNu0qZ4ksUvWPCynkM-Jpil3a5JK_jfm7IL3jwNM_ze480j5JpCQYFW99vCoC5KgGXaC6D0hMypqJscGIVTMoeG8xyqms3IRYxbAKigbM7JjLKKsRLYnNxtPjHrxnbwThkc0GbKpi3DvbcYOtVmccAuM9i2l-TMqTbi1XEuyMfz02b1mq_fX95Wj-vcLFkz5I4K1JU1jmJtuFGOg-UgyhSz1KI0rGSi4porXgkumDLKJsparp02oNVyQW4PvvvQf40YB9n5OAVQO-zHKGuaolMqEkgPoAl9jAGd3AffqfAjKcipILmVqSA5FTSdkihpbo7mo-7Q_imOjSTg4QBgevHbY5DReNwZtD6gGaTt_T_2v3_wdUs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71420118</pqid></control><display><type>article</type><title>The multifaceted adult epidermal stem cell</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Gambardella, Laure ; Barrandon, Yann</creator><creatorcontrib>Gambardella, Laure ; Barrandon, Yann</creatorcontrib><description>Adult epidermal stem cells renew the epithelial compartment of the skin throughout life and are the most accessible of all adult stem cells. Most importantly, epidermal stem cells can be efficiently cultivated and transplanted, a significant advantage for cell and gene therapy. Recent work has pointed to the hair follicle as the main repository of multipotent stem cells in skin. Hair follicles, which are often affected in the mouse by spontaneous or man-made mutations, have become superb model systems to study the cellular and molecular factors that regulate the proliferation, migration and fate of adult stem cells.</description><identifier>ISSN: 0955-0674</identifier><identifier>EISSN: 1879-0410</identifier><identifier>DOI: 10.1016/j.ceb.2003.10.011</identifier><identifier>PMID: 14644204</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Animals ; Cell Differentiation ; Cell Division ; Cell Lineage ; Cell Movement ; Epidermis - cytology ; Epidermis - metabolism ; Genetic Therapy ; Humans ; Models, Biological ; Mutation ; Stem Cells - cytology</subject><ispartof>Current opinion in cell biology, 2003-12, Vol.15 (6), p.771-777</ispartof><rights>2003 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-f18eb6dcf1e7c5caf50d50822002b82c424865b5a568584acad5cadd5bfbc0ba3</citedby><cites>FETCH-LOGICAL-c349t-f18eb6dcf1e7c5caf50d50822002b82c424865b5a568584acad5cadd5bfbc0ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ceb.2003.10.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14644204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gambardella, Laure</creatorcontrib><creatorcontrib>Barrandon, Yann</creatorcontrib><title>The multifaceted adult epidermal stem cell</title><title>Current opinion in cell biology</title><addtitle>Curr Opin Cell Biol</addtitle><description>Adult epidermal stem cells renew the epithelial compartment of the skin throughout life and are the most accessible of all adult stem cells. Most importantly, epidermal stem cells can be efficiently cultivated and transplanted, a significant advantage for cell and gene therapy. Recent work has pointed to the hair follicle as the main repository of multipotent stem cells in skin. Hair follicles, which are often affected in the mouse by spontaneous or man-made mutations, have become superb model systems to study the cellular and molecular factors that regulate the proliferation, migration and fate of adult stem cells.</description><subject>Adult</subject><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Cell Division</subject><subject>Cell Lineage</subject><subject>Cell Movement</subject><subject>Epidermis - cytology</subject><subject>Epidermis - metabolism</subject><subject>Genetic Therapy</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Mutation</subject><subject>Stem Cells - cytology</subject><issn>0955-0674</issn><issn>1879-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LxDAQxYMo7rr6B3iRnjwIrZNu0qZ4ksUvWPCynkM-Jpil3a5JK_jfm7IL3jwNM_ze480j5JpCQYFW99vCoC5KgGXaC6D0hMypqJscGIVTMoeG8xyqms3IRYxbAKigbM7JjLKKsRLYnNxtPjHrxnbwThkc0GbKpi3DvbcYOtVmccAuM9i2l-TMqTbi1XEuyMfz02b1mq_fX95Wj-vcLFkz5I4K1JU1jmJtuFGOg-UgyhSz1KI0rGSi4porXgkumDLKJsparp02oNVyQW4PvvvQf40YB9n5OAVQO-zHKGuaolMqEkgPoAl9jAGd3AffqfAjKcipILmVqSA5FTSdkihpbo7mo-7Q_imOjSTg4QBgevHbY5DReNwZtD6gGaTt_T_2v3_wdUs</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Gambardella, Laure</creator><creator>Barrandon, Yann</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>The multifaceted adult epidermal stem cell</title><author>Gambardella, Laure ; Barrandon, Yann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-f18eb6dcf1e7c5caf50d50822002b82c424865b5a568584acad5cadd5bfbc0ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Cell Differentiation</topic><topic>Cell Division</topic><topic>Cell Lineage</topic><topic>Cell Movement</topic><topic>Epidermis - cytology</topic><topic>Epidermis - metabolism</topic><topic>Genetic Therapy</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Mutation</topic><topic>Stem Cells - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gambardella, Laure</creatorcontrib><creatorcontrib>Barrandon, Yann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gambardella, Laure</au><au>Barrandon, Yann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The multifaceted adult epidermal stem cell</atitle><jtitle>Current opinion in cell biology</jtitle><addtitle>Curr Opin Cell Biol</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>15</volume><issue>6</issue><spage>771</spage><epage>777</epage><pages>771-777</pages><issn>0955-0674</issn><eissn>1879-0410</eissn><abstract>Adult epidermal stem cells renew the epithelial compartment of the skin throughout life and are the most accessible of all adult stem cells. Most importantly, epidermal stem cells can be efficiently cultivated and transplanted, a significant advantage for cell and gene therapy. Recent work has pointed to the hair follicle as the main repository of multipotent stem cells in skin. Hair follicles, which are often affected in the mouse by spontaneous or man-made mutations, have become superb model systems to study the cellular and molecular factors that regulate the proliferation, migration and fate of adult stem cells.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>14644204</pmid><doi>10.1016/j.ceb.2003.10.011</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-0674 |
| ispartof | Current opinion in cell biology, 2003-12, Vol.15 (6), p.771-777 |
| issn | 0955-0674 1879-0410 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71420118 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Animals Cell Differentiation Cell Division Cell Lineage Cell Movement Epidermis - cytology Epidermis - metabolism Genetic Therapy Humans Models, Biological Mutation Stem Cells - cytology |
| title | The multifaceted adult epidermal stem cell |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T20%3A07%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20multifaceted%20adult%20epidermal%20stem%20cell&rft.jtitle=Current%20opinion%20in%20cell%20biology&rft.au=Gambardella,%20Laure&rft.date=2003-12-01&rft.volume=15&rft.issue=6&rft.spage=771&rft.epage=777&rft.pages=771-777&rft.issn=0955-0674&rft.eissn=1879-0410&rft_id=info:doi/10.1016/j.ceb.2003.10.011&rft_dat=%3Cproquest_cross%3E71420118%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71420118&rft_id=info:pmid/14644204&rft_els_id=S0955067403001388&rfr_iscdi=true |