Bioavailability of Theophylline and Thiamine Disulfide Incorporated into Mucoadhesive Microspheres Consisting of Dextran Derivatives and Cellulose Acetate Butyrate

Mucoadhesive microspheres made of oppositely charged dextran derivatives and cellulose acetate butyrate (Ad-MS) were evaluated for their ability to improve the bioavailability of theophylline (TH) and thiamine disulfide (TDS). A drug suspension (or solution) and non-adhesive microspheres (MS) were u...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2003, Vol.26(12), pp.1744-1747
Hauptverfasser:	Miyazaki, Yasunori, Ogihara, Kanako, Yakou, Shigeru, Nagai, Tsuneji, Takayama, Kozo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesiveness Administration, Oral Animals Area Under Curve bioavailability Biological and medical sciences Biological Availability Cellulose - administration & dosage Cellulose - analogs & derivatives Cellulose - chemistry Cellulose - pharmacokinetics dextran derivative Dextrans - administration & dosage Dextrans - chemistry Dextrans - pharmacokinetics Digestive System - drug effects Digestive System - metabolism Dosage Forms gastrointestinal transit General pharmacology Intestinal Absorption - drug effects Medical sciences Microspheres mucoadhesive microsphere Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Solutions Suspensions theophylline Theophylline - administration & dosage Theophylline - blood Theophylline - pharmacokinetics Thiamine - administration & dosage Thiamine - analogs & derivatives Thiamine - blood Thiamine - pharmacokinetics thiamine disulfide
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