Upregulation of bcl‐2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines

Chemotherapeutic drugs eliminate cancer cells by induction of apoptosis. Resistance to chemotherapy is partly due to a decreased apoptosis rate. Here we investigated resistance to anticancer drugs in 9 small cell lung cancer (SCLC) cell lines. Apoptosis was induced by cisplatin, doxorubicin and etop...

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Veröffentlicht in:	International journal of cancer 2002-02, Vol.97 (5), p.584-592
Hauptverfasser:	Sartorius, Ute A., Krammer, Peter H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects bcl‐2 Biological and medical sciences Carcinoma, Small Cell - chemistry Carcinoma, Small Cell - drug therapy Carcinoma, Small Cell - metabolism Caspases - metabolism Cell Survival - drug effects Chemotherapy Cisplatin - pharmacology Doxorubicin - pharmacology Drug Resistance, Neoplasm Etoposide - pharmacology Fas Ligand Protein fas Receptor - analysis Humans lung carcinoma Lung Neoplasms - chemistry Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Medical sciences Membrane Glycoproteins - analysis mitochondria Mitochondria - drug effects Mitochondria - metabolism Neoplasms, Experimental - chemistry Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Oligonucleotides, Antisense - pharmacology Pharmacology. Drug treatments Phenotype Pneumology Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism small cell lung cancer Transfection Tumor Cells, Cultured Tumors of the respiratory system and mediastinum Up-Regulation
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