Cranial expression of class 3 secreted semaphorins and their neuropilin receptors
The semaphorin family of chemorepellents and their receptors the neuropilins are implicated in a variety of cellular processes, including axon guidance and cell migration. Semaphorins may bind more than one neuropilin or a heterodimer of both, thus a detailed knowledge of their expression patterns m...
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| Veröffentlicht in: | Developmental dynamics 2003-12, Vol.228 (4), p.726-733 |
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| container_title | Developmental dynamics |
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| creator | Chilton, John K. Guthrie, Sarah |
| description | The semaphorin family of chemorepellents and their receptors the neuropilins are implicated in a variety of cellular processes, including axon guidance and cell migration. Semaphorins may bind more than one neuropilin or a heterodimer of both, thus a detailed knowledge of their expression patterns may reveal possible cases of redundancy or mutual antagonism. To assess their involvement in cranial development, we cloned fragments of the chick orthologues of Sema3B and Sema3F. We then carried out mRNA in situ hybridisation of all six class 3 semaphorins and both neuropilins in the embryonic chick head. We present evidence for spatiotemporal regulation of these molecules in the brainstem and developing head, including the eye, ear, and branchial arches. These expression patterns provide a basis for functional analysis of semaphorins and neuropilins in the development of axon projections and the morphogenesis of cranial structures. Developmental Dynamics 228:726–733, 2003. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/dvdy.10396 |
| format | Article |
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Semaphorins may bind more than one neuropilin or a heterodimer of both, thus a detailed knowledge of their expression patterns may reveal possible cases of redundancy or mutual antagonism. To assess their involvement in cranial development, we cloned fragments of the chick orthologues of Sema3B and Sema3F. We then carried out mRNA in situ hybridisation of all six class 3 semaphorins and both neuropilins in the embryonic chick head. We present evidence for spatiotemporal regulation of these molecules in the brainstem and developing head, including the eye, ear, and branchial arches. These expression patterns provide a basis for functional analysis of semaphorins and neuropilins in the development of axon projections and the morphogenesis of cranial structures. Developmental Dynamics 228:726–733, 2003. © 2003 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Axons - metabolism</subject><subject>Brain - embryology</subject><subject>branchial arch</subject><subject>Cell Movement</subject><subject>Chick Embryo</subject><subject>Cloning, Molecular</subject><subject>Dimerization</subject><subject>DNA, Complementary - metabolism</subject><subject>Ear - embryology</subject><subject>eye</subject><subject>Eye - embryology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Head - embryology</subject><subject>hindbrain</subject><subject>In Situ Hybridization</subject><subject>Membrane Glycoproteins - biosynthesis</subject><subject>Membrane Glycoproteins - genetics</subject><subject>neuropilin</subject><subject>Neuropilins - biosynthesis</subject><subject>otic vesicle</subject><subject>RNA, Messenger - metabolism</subject><subject>semaphorin</subject><subject>Semaphorins - biosynthesis</subject><subject>Semaphorins - genetics</subject><subject>Time Factors</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9LwzAYh4Mobk4vfgDJyYNQTZo0TY6y-Q8EEVTwVLLkLYu0TU1add_ezg686Sk_yMMD74PQMSXnlJD0wn7Y9bCYEjtoSonKE0LzfHezM5lIJuUEHcT4RgiRgtN9NKFccCm5mqLHedCN0xWGrzZAjM432JfYVDpGzHAEE6ADO4xatysfXBOxbizuVuACbqAPvnWVa3AAA23nQzxEe6WuIhxt3xl6vr56mt8m9w83d_PL-8QwlYqklCS1hIMUBBhllBpusqxM7fDLMsjTnAwXWSlLxZRhlANdcrNkopSMSqvYDJ2O3jb49x5iV9QuGqgq3YDvY5FTTnOp-L9gSnhKhBIDeDaCJvgYA5RFG1ytw7qgpNiULjali5_SA3yytfbLGuwvuk07AHQEPl0F6z9UxeJl8TpKvwFQx4hj</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>Chilton, John K.</creator><creator>Guthrie, Sarah</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200312</creationdate><title>Cranial expression of class 3 secreted semaphorins and their neuropilin receptors</title><author>Chilton, John K. ; Guthrie, Sarah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3926-f802d04e860e31311c4c55f2d39235e7270039d88f939c314e1b4cb36f8318d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Axons - metabolism</topic><topic>Brain - embryology</topic><topic>branchial arch</topic><topic>Cell Movement</topic><topic>Chick Embryo</topic><topic>Cloning, Molecular</topic><topic>Dimerization</topic><topic>DNA, Complementary - metabolism</topic><topic>Ear - embryology</topic><topic>eye</topic><topic>Eye - embryology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Head - embryology</topic><topic>hindbrain</topic><topic>In Situ Hybridization</topic><topic>Membrane Glycoproteins - biosynthesis</topic><topic>Membrane Glycoproteins - genetics</topic><topic>neuropilin</topic><topic>Neuropilins - biosynthesis</topic><topic>otic vesicle</topic><topic>RNA, Messenger - metabolism</topic><topic>semaphorin</topic><topic>Semaphorins - biosynthesis</topic><topic>Semaphorins - genetics</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chilton, John K.</creatorcontrib><creatorcontrib>Guthrie, Sarah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chilton, John K.</au><au>Guthrie, Sarah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cranial expression of class 3 secreted semaphorins and their neuropilin receptors</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2003-12</date><risdate>2003</risdate><volume>228</volume><issue>4</issue><spage>726</spage><epage>733</epage><pages>726-733</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><abstract>The semaphorin family of chemorepellents and their receptors the neuropilins are implicated in a variety of cellular processes, including axon guidance and cell migration. 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| subjects | Animals Axons - metabolism Brain - embryology branchial arch Cell Movement Chick Embryo Cloning, Molecular Dimerization DNA, Complementary - metabolism Ear - embryology eye Eye - embryology Gene Expression Regulation, Developmental Head - embryology hindbrain In Situ Hybridization Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics neuropilin Neuropilins - biosynthesis otic vesicle RNA, Messenger - metabolism semaphorin Semaphorins - biosynthesis Semaphorins - genetics Time Factors |
| title | Cranial expression of class 3 secreted semaphorins and their neuropilin receptors |
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