Synthetic studies towards congeners of phomactin A. Re-examination of the structure of Sch 49028

The total syntheses of the epoxy cyclic hemiacetal structures 8 and 9, which are isomeric with the structure 6 proposed for the phomactin known as Sch 49028 isolated from the marine fungus Phoma sp. are described. Neither of these structures showed spectroscopic data consistent with those reported f...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2003-11 (22), p.2788-2789
Hauptverfasser: Cheing, John W C, Goldring, William P D, Pattenden, Gerald
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creator Cheing, John W C
Goldring, William P D
Pattenden, Gerald
description The total syntheses of the epoxy cyclic hemiacetal structures 8 and 9, which are isomeric with the structure 6 proposed for the phomactin known as Sch 49028 isolated from the marine fungus Phoma sp. are described. Neither of these structures showed spectroscopic data consistent with those reported for the purported natural product, adding credibility to the proposal that the structure Sch 49028 does not exist in nature and that its NMR spectroscopic data should have been assigned as phomactin A (1).
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source Royal Society of Chemistry Journals Archive (1841-2007); MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Heterocyclic Compounds, 4 or More Rings - chemical synthesis
Heterocyclic Compounds, 4 or More Rings - chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
title Synthetic studies towards congeners of phomactin A. Re-examination of the structure of Sch 49028
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