Synthetic studies towards congeners of phomactin A. Re-examination of the structure of Sch 49028
The total syntheses of the epoxy cyclic hemiacetal structures 8 and 9, which are isomeric with the structure 6 proposed for the phomactin known as Sch 49028 isolated from the marine fungus Phoma sp. are described. Neither of these structures showed spectroscopic data consistent with those reported f...
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Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2003-11 (22), p.2788-2789 |
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creator | Cheing, John W C Goldring, William P D Pattenden, Gerald |
description | The total syntheses of the epoxy cyclic hemiacetal structures 8 and 9, which are isomeric with the structure 6 proposed for the phomactin known as Sch 49028 isolated from the marine fungus Phoma sp. are described. Neither of these structures showed spectroscopic data consistent with those reported for the purported natural product, adding credibility to the proposal that the structure Sch 49028 does not exist in nature and that its NMR spectroscopic data should have been assigned as phomactin A (1). |
doi_str_mv | 10.1039/b310753a |
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source | Royal Society of Chemistry Journals Archive (1841-2007); MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
subjects | Heterocyclic Compounds, 4 or More Rings - chemical synthesis Heterocyclic Compounds, 4 or More Rings - chemistry Magnetic Resonance Spectroscopy Molecular Structure |
title | Synthetic studies towards congeners of phomactin A. Re-examination of the structure of Sch 49028 |
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