Replication of an adenoviral vector controlled by the human telomerase reverse transcriptase promoter causes tumor-selective tumor lysis

Telomerase reactivation is a critical step for tumorigenesis, allowing cancer cells to proliferate indefinitely. Taking advantage of this property, we generated an adenovirus vector in which E1 gene expression, and therefore viral replication, is under control of the human telomerase reverse transcr...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-11, Vol.63 (22), p.7936-7941
Hauptverfasser:	LANSON, Nicholas A, FRIEDLANDER, Paul L, SCHWARZENBERGER, Paul, KOLLS, Jay K, GUOSHUN WANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus E1 Proteins - genetics Adenoviruses, Human - genetics Adenoviruses, Human - physiology Adult Antineoplastic agents Biological and medical sciences Cell Line, Tumor Cytopathogenic Effect, Viral DNA-Binding Proteins Genetic Vectors - genetics Humans Male Medical sciences Neoplasms - pathology Neoplasms - therapy Neoplasms - virology Pharmacology. Drug treatments Promoter Regions, Genetic Telomerase - genetics Telomerase - metabolism Tumors Virus Replication - genetics Virus Replication - physiology Xenograft Model Antitumor Assays
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