Enhanced Activity of the Plasma Membrane Oxidoreductase in Circulating Lymphocytes from Insulin-Dependent Diabetes Mellitus Patients

Circulating human lymphocytes contain a transmembrane oxidoreductase (PMOR) capable of reducing dichlorophenol indophenol (DCIP) by endogenous reductants, presumably NADH. Membranes from lymphocytes obtained from buffy coats contain a NADH DCIP reductase having a Km of about 1 μM and almost insensib...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002-02, Vol.290 (5), p.1589-1592
Hauptverfasser:	Lenaz, Giorgio, Paolucci, Ugo, Fato, Romana, D'Aurelio, Marilena, Parenti Castelli, Giovanna, Sgarbi, Gianluca, Biagini, Graziella, Ragni, Luca, Salardi, Silvana, Cacciari, Emanuele
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Cell Membrane - enzymology Child Cytosol - enzymology Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - enzymology Diabetes Mellitus, Type 1 - pathology Dicumarol - pharmacology DT-diaphorase Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Humans insulin-dependent diabetes mellitus lymphocytes Lymphocytes - enzymology Lymphocytes - metabolism Lymphocytes - pathology NAD - blood NAD(P)H Dehydrogenase (Quinone) - biosynthesis NAD(P)H Dehydrogenase (Quinone) - blood NADH, NADPH Oxidoreductases - biosynthesis NADH, NADPH Oxidoreductases - blood NADH, NADPH Oxidoreductases - metabolism plasma membrane oxidoreductase
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