Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells

Red blood cells (RBCs) parasitized by Plasmodium falciparum are rigid and poorly deformable and show abnormal circulatory behavior. During parasite development, knob-associated histidine-rich protein (KAHRP) and P falciparum erythrocyte membrane protein 3 (PfEMP3) are exported from the parasite and...

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Veröffentlicht in:	Blood 2002-02, Vol.99 (3), p.1060-1063
Hauptverfasser:	Glenister, Fiona K., Coppel, Ross L., Cowman, Alan F., Mohandas, Narla, Cooke, Brian M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomechanical Phenomena Elasticity - drug effects Erythrocyte Membrane - drug effects Erythrocyte Membrane - parasitology Erythrocytes - parasitology Erythrocytes - pathology Human protozoal diseases Humans Infectious diseases Malaria Malaria, Falciparum - blood Medical sciences Membrane Proteins - pharmacology Parasitic diseases Peptides - pharmacology Plasmodium falciparum - chemistry Plasmodium falciparum - genetics Protozoal diseases Protozoan Proteins - genetics Protozoan Proteins - pharmacology
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