Lactate inhibits germ cell apoptosis in the human testis

Dysregulation of male germ cell apoptosis has been associated with the pathogenesis of male infertility. Therefore, factors involved in the regulation of germ cell death are being actively investigated. Here, we studied the effects of lactate on human male germ cell death, using as a model a testis...

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Veröffentlicht in:	Molecular human reproduction 2002-02, Vol.8 (2), p.109-117
Hauptverfasser:	Erkkilä, K., Aito, H., Aalto, K., Pentikäinen, V., Dunkel, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - metabolism Aged Aged, 80 and over Apoptosis Biological and medical sciences Culture Techniques fas Receptor - physiology Fundamental and applied biological sciences. Psychology germ cell Hormone metabolism and regulation human testis Humans In Situ Nick-End Labeling lactate Lactic Acid - metabolism Male Mammalian male genital system Models, Biological Oxidative Phosphorylation Prostatic Neoplasms Seminiferous Tubules - metabolism Seminiferous Tubules - physiology Seminiferous Tubules - ultrastructure spermatogenesis Spermatogenesis - physiology Spermatozoa - metabolism Spermatozoa - physiology Spermatozoa - ultrastructure Vertebrates: reproduction
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