GnRH regulates early growth response protein 1 transcription through multiple promoter elements

Pulsatile secretion of GnRH is the major regulator of gonadotropin (LH, FSH) gene expression and secretion. Recently, GnRH has been shown to rapidly stimulate the expression of early growth response protein-1 (Egr-1), a transcription factor that is essential for LHbeta gene expression in the pituita...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2002-02, Vol.16 (2), p.221-233
Hauptverfasser:	Duan, W Rachel, Ito, Masafumi, Park, Youngkyu, Maizels, Evelyn T, Hunzicker-Dunn, Mary, Jameson, J Larry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Blotting, Western Cells, Cultured Cyclic AMP Response Element-Binding Protein - metabolism DNA-Binding Proteins - genetics Early Growth Response Protein 1 Electrophoretic Mobility Shift Assay Enzyme Activation - drug effects ets-Domain Protein Elk-1 Gene Expression Regulation - drug effects Gonadotropin-Releasing Hormone - pharmacology Immediate-Early Proteins Indoles - pharmacology Maleimides - pharmacology Mice Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects Pituitary Gland - cytology Pituitary Gland - drug effects Pituitary Gland - enzymology Pituitary Gland - metabolism Promoter Regions, Genetic - genetics Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-ets Ribosomal Protein S6 Kinases - metabolism Sequence Deletion - genetics Serum Response Element - genetics Serum Response Factor - metabolism Signal Transduction - drug effects Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - drug effects Transcription, Genetic - genetics
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