Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy
Polygalasaponins were extracted from a plant ( Polygala tenuifolia Willdenow) that has been prescribed for hundreds of years to treat psychotic illnesses in Korean traditional medicine. Previous in vitro binding studies suggested a potential mechanism for its antipsychotic action, as polygalasaponin...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-01, Vol.71 (1), p.191-195 |
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| creator | Chung, In-Won Moore, Nicholas A. Oh, Won-Keun O'Neill, Michael F. Ahn, Jong-Seog Park, Joo-Bae Kang, Ung Gu Kim, Yong Sik |
| description | Polygalasaponins were extracted from a plant (
Polygala
tenuifolia Willdenow) that has been prescribed for hundreds of years to treat psychotic illnesses in Korean traditional medicine. Previous in vitro binding studies suggested a potential mechanism for its antipsychotic action, as polygalasaponin was shown to have an affinity for both dopamine and serotonin receptors [Psychopharmacol. Bull. 31 (1995) 139.]. In the present study we have investigated the functional in vivo actions of this material in tests that are predictive of dopamine and serotonin antagonist activities. Polygalasaponin (25–500 mg/kg) was shown to produce a dose-related reduction in the apomorphine-induced climbing behaviour (minimum effective dose [ED
min] 25 mg/kg ip, 250 mg/kg sc and po), the 5-hydroxytryptamine (5-HTP)-induced serotonin syndrome (ED
min 50 mg/kg ip) and the MK-801-induced hyperactivity (ED
min 25 mg/kg ip) in mice. This compound also reduced the cocaine-induced hyperactivity (ED
min 25 mg/kg ip) in rats. These results demonstrated that polygalasaponin has dopamine and serotonin receptor antagonist properties in vivo. This might suggest its possible utility as an antipsychotic agent. |
| doi_str_mv | 10.1016/S0091-3057(01)00648-7 |
| format | Article |
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Polygala
tenuifolia Willdenow) that has been prescribed for hundreds of years to treat psychotic illnesses in Korean traditional medicine. Previous in vitro binding studies suggested a potential mechanism for its antipsychotic action, as polygalasaponin was shown to have an affinity for both dopamine and serotonin receptors [Psychopharmacol. Bull. 31 (1995) 139.]. In the present study we have investigated the functional in vivo actions of this material in tests that are predictive of dopamine and serotonin antagonist activities. Polygalasaponin (25–500 mg/kg) was shown to produce a dose-related reduction in the apomorphine-induced climbing behaviour (minimum effective dose [ED
min] 25 mg/kg ip, 250 mg/kg sc and po), the 5-hydroxytryptamine (5-HTP)-induced serotonin syndrome (ED
min 50 mg/kg ip) and the MK-801-induced hyperactivity (ED
min 25 mg/kg ip) in mice. This compound also reduced the cocaine-induced hyperactivity (ED
min 25 mg/kg ip) in rats. These results demonstrated that polygalasaponin has dopamine and serotonin receptor antagonist properties in vivo. This might suggest its possible utility as an antipsychotic agent.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(01)00648-7</identifier><identifier>PMID: 11812522</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Antipsychotic Agents - pharmacology ; Antipsychotics ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Behavioural pharmacology ; Biological and medical sciences ; Climbing behaviour ; Dopamine ; Dose-Response Relationship, Drug ; Female ; General pharmacology ; Magnoliopsida ; Male ; Medical sciences ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy - methods ; Plant Extracts - pharmacology ; Plant Roots ; Polygala ; Polygalasaponin ; Rats ; Receptors, Dopamine - physiology ; Receptors, Serotonin - physiology ; Saponins - pharmacology ; Serotonin</subject><ispartof>Pharmacology, biochemistry and behavior, 2002-01, Vol.71 (1), p.191-195</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-d105c9dc28242164f570477e295ea8b39ad1b21ff35f5426684ee4c8fe95c3603</citedby><cites>FETCH-LOGICAL-c474t-d105c9dc28242164f570477e295ea8b39ad1b21ff35f5426684ee4c8fe95c3603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091305701006487$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13460199$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11812522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, In-Won</creatorcontrib><creatorcontrib>Moore, Nicholas A.</creatorcontrib><creatorcontrib>Oh, Won-Keun</creatorcontrib><creatorcontrib>O'Neill, Michael F.</creatorcontrib><creatorcontrib>Ahn, Jong-Seog</creatorcontrib><creatorcontrib>Park, Joo-Bae</creatorcontrib><creatorcontrib>Kang, Ung Gu</creatorcontrib><creatorcontrib>Kim, Yong Sik</creatorcontrib><title>Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Polygalasaponins were extracted from a plant (
Polygala
tenuifolia Willdenow) that has been prescribed for hundreds of years to treat psychotic illnesses in Korean traditional medicine. Previous in vitro binding studies suggested a potential mechanism for its antipsychotic action, as polygalasaponin was shown to have an affinity for both dopamine and serotonin receptors [Psychopharmacol. Bull. 31 (1995) 139.]. In the present study we have investigated the functional in vivo actions of this material in tests that are predictive of dopamine and serotonin antagonist activities. Polygalasaponin (25–500 mg/kg) was shown to produce a dose-related reduction in the apomorphine-induced climbing behaviour (minimum effective dose [ED
min] 25 mg/kg ip, 250 mg/kg sc and po), the 5-hydroxytryptamine (5-HTP)-induced serotonin syndrome (ED
min 50 mg/kg ip) and the MK-801-induced hyperactivity (ED
min 25 mg/kg ip) in mice. This compound also reduced the cocaine-induced hyperactivity (ED
min 25 mg/kg ip) in rats. These results demonstrated that polygalasaponin has dopamine and serotonin receptor antagonist properties in vivo. This might suggest its possible utility as an antipsychotic agent.</description><subject>Animals</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Antipsychotics</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioural pharmacology</subject><subject>Biological and medical sciences</subject><subject>Climbing behaviour</subject><subject>Dopamine</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Magnoliopsida</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy - methods</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots</subject><subject>Polygala</subject><subject>Polygalasaponin</subject><subject>Rats</subject><subject>Receptors, Dopamine - physiology</subject><subject>Receptors, Serotonin - physiology</subject><subject>Saponins - pharmacology</subject><subject>Serotonin</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EotvCTwDlQgWHlBl_xMkJ0apApUocAHG0vM64a5SNg52tlH-Pt7uix57mMM878-ph7A3CBQI2H38AdFgLUPo94AeARra1fsZW2GpRK9T6OVv9R07Yac5_AEDyRr9kJ4gtcsX5iv2-pI29D3GX7FBNG5u21sUh3i1V9NUUh-XODjbbKY5hzFUY--DsTLmsZhrnUEK2jCkvbhPn4CryvhBuecVeeDtken2cZ-zXl-ufV9_q2-9fb64-39ZOajnXPYJyXe94yyXHRnqlQWpNvFNk27XobI9rjt4L5VUp37SSSLrWU6ecaECcsfPD3SnFvzvKs9mG7GgY7Ehxl41GiRKwexLEVmgQyAuoDqBLMedE3kwpbG1aDILZqzcP6s3eqwE0D-qNLrm3xwe79Zb6x9TRdQHeHQGbnR18sqML-ZETsilF900_HTgq3u4DJZNdoNFRHxK52fQxPFHlHyYnoO4</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Chung, In-Won</creator><creator>Moore, Nicholas A.</creator><creator>Oh, Won-Keun</creator><creator>O'Neill, Michael F.</creator><creator>Ahn, Jong-Seog</creator><creator>Park, Joo-Bae</creator><creator>Kang, Ung Gu</creator><creator>Kim, Yong Sik</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy</title><author>Chung, In-Won ; Moore, Nicholas A. ; Oh, Won-Keun ; O'Neill, Michael F. ; Ahn, Jong-Seog ; Park, Joo-Bae ; Kang, Ung Gu ; Kim, Yong Sik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-d105c9dc28242164f570477e295ea8b39ad1b21ff35f5426684ee4c8fe95c3603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Antipsychotics</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioural pharmacology</topic><topic>Biological and medical sciences</topic><topic>Climbing behaviour</topic><topic>Dopamine</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Magnoliopsida</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy - methods</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots</topic><topic>Polygala</topic><topic>Polygalasaponin</topic><topic>Rats</topic><topic>Receptors, Dopamine - physiology</topic><topic>Receptors, Serotonin - physiology</topic><topic>Saponins - pharmacology</topic><topic>Serotonin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, In-Won</creatorcontrib><creatorcontrib>Moore, Nicholas A.</creatorcontrib><creatorcontrib>Oh, Won-Keun</creatorcontrib><creatorcontrib>O'Neill, Michael F.</creatorcontrib><creatorcontrib>Ahn, Jong-Seog</creatorcontrib><creatorcontrib>Park, Joo-Bae</creatorcontrib><creatorcontrib>Kang, Ung Gu</creatorcontrib><creatorcontrib>Kim, Yong Sik</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, In-Won</au><au>Moore, Nicholas A.</au><au>Oh, Won-Keun</au><au>O'Neill, Michael F.</au><au>Ahn, Jong-Seog</au><au>Park, Joo-Bae</au><au>Kang, Ung Gu</au><au>Kim, Yong Sik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>71</volume><issue>1</issue><spage>191</spage><epage>195</epage><pages>191-195</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Polygalasaponins were extracted from a plant (
Polygala
tenuifolia Willdenow) that has been prescribed for hundreds of years to treat psychotic illnesses in Korean traditional medicine. Previous in vitro binding studies suggested a potential mechanism for its antipsychotic action, as polygalasaponin was shown to have an affinity for both dopamine and serotonin receptors [Psychopharmacol. Bull. 31 (1995) 139.]. In the present study we have investigated the functional in vivo actions of this material in tests that are predictive of dopamine and serotonin antagonist activities. Polygalasaponin (25–500 mg/kg) was shown to produce a dose-related reduction in the apomorphine-induced climbing behaviour (minimum effective dose [ED
min] 25 mg/kg ip, 250 mg/kg sc and po), the 5-hydroxytryptamine (5-HTP)-induced serotonin syndrome (ED
min 50 mg/kg ip) and the MK-801-induced hyperactivity (ED
min 25 mg/kg ip) in mice. This compound also reduced the cocaine-induced hyperactivity (ED
min 25 mg/kg ip) in rats. These results demonstrated that polygalasaponin has dopamine and serotonin receptor antagonist properties in vivo. This might suggest its possible utility as an antipsychotic agent.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11812522</pmid><doi>10.1016/S0091-3057(01)00648-7</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Antipsychotic Agents - pharmacology Antipsychotics Behavior, Animal - drug effects Behavior, Animal - physiology Behavioural pharmacology Biological and medical sciences Climbing behaviour Dopamine Dose-Response Relationship, Drug Female General pharmacology Magnoliopsida Male Medical sciences Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy - methods Plant Extracts - pharmacology Plant Roots Polygala Polygalasaponin Rats Receptors, Dopamine - physiology Receptors, Serotonin - physiology Saponins - pharmacology Serotonin |
| title | Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy |
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