Antibody-directed therapies for hematological malignancies

Malignant hematopoietic cells express lineage-restricted antigens that serve as suitable targets for antibody-directed therapy. Although several highly specific, potent and relatively nontoxic, engineered antibodies, immunoglobulin fragments and antibody conjugates have been developed, only three ha...

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Veröffentlicht in:	Trends in Molecular Medicine 2002-02, Vol.8 (2), p.69-76
Hauptverfasser:	Linenberger, Michael L, Maloney, David G, Bernstein, Irwin D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Antibodies - therapeutic use Antibody Specificity antigen Antigens, Neoplasm - immunology Antigens, Surface - immunology Endocytosis Hematologic Neoplasms - immunology Hematologic Neoplasms - therapy Humans Immunoconjugates - immunology Immunoconjugates - therapeutic use Immunotherapy - methods immunotoxin leukemia Lymphoma monoclonal antibody radioimmunoconjugate Recombinant Proteins - therapeutic use
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