Mechanisms of translational control in dendrites
Synaptogenesis and synaptic plasticity demonstrate the ability of neurons to mature and respond to various stimuli. Both of these events require protein synthesis, in particular, localized translation within dendrites. Dendrites localize specific mRNAs in proximity to dendritic spines and have the c...
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| Veröffentlicht in: | Neurobiology of aging 2003-12, Vol.24 (8), p.1105-1111 |
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| container_title | Neurobiology of aging |
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| creator | Glanzer, Jason G. Eberwine, James H. |
| description | Synaptogenesis and synaptic plasticity demonstrate the ability of neurons to mature and respond to various stimuli. Both of these events require protein synthesis, in particular, localized translation within dendrites. Dendrites localize specific mRNAs in proximity to dendritic spines and have the capacity to actively translate these mRNAs within various ‘hotspots’ in the dendritic space. Rates of dendritic translation are stimulated and inhibited by various agents, suggesting that several signaling pathways that modulate localized protein synthesis may exist within the dendrite. This review will cover several suggested pathways for regulation of dendritic translation and propose a correlation between deregulated dendritic translation and disease. |
| doi_str_mv | 10.1016/j.neurobiolaging.2003.04.006 |
| format | Article |
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Both of these events require protein synthesis, in particular, localized translation within dendrites. Dendrites localize specific mRNAs in proximity to dendritic spines and have the capacity to actively translate these mRNAs within various ‘hotspots’ in the dendritic space. Rates of dendritic translation are stimulated and inhibited by various agents, suggesting that several signaling pathways that modulate localized protein synthesis may exist within the dendrite. This review will cover several suggested pathways for regulation of dendritic translation and propose a correlation between deregulated dendritic translation and disease.</description><subject>Alzheimer</subject><subject>Animals</subject><subject>APRA</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dendrites</subject><subject>Dendrites - metabolism</subject><subject>Humans</subject><subject>IRES</subject><subject>Medical sciences</subject><subject>mRNA transfection</subject><subject>mTOR</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Neurology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Parkinson</subject><subject>Protein Biosynthesis - physiology</subject><subject>Rapamycin</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>Synaptic plasticity</subject><subject>Translation</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkT1vFDEQhi0EIkfgL6AtANHsMv72SjQoIoCUKA3UlteeDT7t2cHeQ8q_x6c7KaKBVNM8M_N-EPKGwkCBqg_bIeG-5Cnmxd3GdDswAD6AGADUE7KhUpqeilE_JRugo-6FNHBGXtS6BQAttHpOzqhQgnPDNgSu0f90KdZd7fLcrcWlurg15uSWzue0lrx0MXUBUyhxxfqSPJvdUvHVaZ6TH5efv1987a9uvny7-HTV-_Zi7Y0bGTCpkSk5jb5pU8ZL49zsp5mzwMIEXo1Uz8Zx5Z3TkwuTVMKgNMEwfk7eHe_elfxrj3W1u1g9LotLmPfVaiooA64b-P6fIDVaGtmM8__epFqZ0ZgD-PEI-pJrLTjbuxJ3rtxbCvbQgt3av1uwhxYsCNuctvXXpz_7aYfhYfkUewPengBXvVvmlrqP9YGTnCvNTeMujxy2pH9HLLb6iMljiAX9akOOj1P0B7uHrZw</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Glanzer, Jason G.</creator><creator>Eberwine, James H.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Mechanisms of translational control in dendrites</title><author>Glanzer, Jason G. ; Eberwine, James H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-8a920257e265b9c00668c58aafcbf32d2db0c6917f8a36caa7badb5648e58d823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Alzheimer</topic><topic>Animals</topic><topic>APRA</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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| ispartof | Neurobiology of aging, 2003-12, Vol.24 (8), p.1105-1111 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alzheimer Animals APRA Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dendrites Dendrites - metabolism Humans IRES Medical sciences mRNA transfection mTOR Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neurology Neuronal Plasticity - physiology Parkinson Protein Biosynthesis - physiology Rapamycin RNA, Messenger - metabolism Signal Transduction - physiology Synaptic plasticity Translation |
| title | Mechanisms of translational control in dendrites |
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