Influence of ethylene-Oxy spacer group on the activity of linezolid: Synthesis of potent antibacterials possessing a thiocarbonyl group

The influence of an ethylene-oxy spacer element between the heterocycle and the aromatic ring in linezolid is reported. The introduction of such spacer group generated compounds with inferior antibacterial activity. However, the conversion of the acetamide group present in the linezolid analogues to...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-12, Vol.13 (23), p.4169-4172
Hauptverfasser:	Selvakumar, N., Raheem, Mohammed A., Khera, Manoj Kumar, Rajale, Trideep V., Kumar, Magadi Sitaram, Kandepu, Sreenivas, Das, Jagattaran, Rajagopalan, R., Iqbal, Javed, Trehan, Sanjay
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - chemical synthesis Acetamides - chemistry Acetamides - pharmacology Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Bacteria - drug effects Ethylenes - chemistry Linezolid Microbial Sensitivity Tests Molecular Structure Oxazolidinones - chemical synthesis Oxazolidinones - chemistry Oxazolidinones - pharmacology Structure-Activity Relationship Thioacetamide - chemical synthesis Thioacetamide - chemistry Thioacetamide - pharmacology
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