ADAM33 Is Not Associated with Asthma in Puerto Rican or Mexican Populations
A recent study identified the ADAM33 gene as a promising candidate contributing to asthma. In Puerto Rican and Mexican populations, we have genotyped six single nucleotide polymorphisms (SNPs) that were used in the Genetics of Asthma in Latino Americans Study. We chose to study these two populations...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2003-12, Vol.168 (11), p.1312-1316 |
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| creator | Lind, Denise L Choudhry, Shweta Ung, Ngim Ziv, Elad Avila, Pedro C Salari, Keyan Ha, Connie Lovins, Elizabeth G Coyle, Natasha E Nazario, Sylvette Casal, Jesus Torres, Alfonso Rodriguez-Santana, Jose R Matallana, Henry Lilly, Craig M Salas, Jorge Selman, Moises Boushey, Homer A Weiss, Scott T Chapela, Rocio Ford, Jean G Rodriguez-Cintron, William Silverman, Edwin K Sheppard, Dean Kwok, Pui-Yan Burchard, Esteban Gonzalez |
| description | A recent study identified the ADAM33 gene as a promising candidate contributing to asthma. In Puerto Rican and Mexican populations, we have genotyped six single nucleotide polymorphisms (SNPs) that were used in the Genetics of Asthma in Latino Americans Study. We chose to study these two populations because in the United States, Puerto Ricans have the highest asthma prevalence, morbidity, and mortality and Mexicans the lowest. We used the transmission disequilibrium test to analyze associations between the ADAM33 gene variants and asthma, asthma severity, bronchodilator responsiveness, and total IgE levels using single SNPs, two to six SNP combinations, and specific haplotypes in 583 trios (proband with asthma and both biological parents). We also genotyped matched control samples to allow case-control analyses. None of the transmission disequilibrium test or case-control results showed significant association in either population. We found no evidence for association of single SNPs with asthma severity, bronchodilator response, or IgE levels in Mexicans or in the combined population. Two SNPs showed a modest association in Puerto Ricans, insignificant when the number of comparisons was taken into account. We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans. |
| doi_str_mv | 10.1164/rccm.200306-877OC |
| format | Article |
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In Puerto Rican and Mexican populations, we have genotyped six single nucleotide polymorphisms (SNPs) that were used in the Genetics of Asthma in Latino Americans Study. We chose to study these two populations because in the United States, Puerto Ricans have the highest asthma prevalence, morbidity, and mortality and Mexicans the lowest. We used the transmission disequilibrium test to analyze associations between the ADAM33 gene variants and asthma, asthma severity, bronchodilator responsiveness, and total IgE levels using single SNPs, two to six SNP combinations, and specific haplotypes in 583 trios (proband with asthma and both biological parents). We also genotyped matched control samples to allow case-control analyses. None of the transmission disequilibrium test or case-control results showed significant association in either population. We found no evidence for association of single SNPs with asthma severity, bronchodilator response, or IgE levels in Mexicans or in the combined population. Two SNPs showed a modest association in Puerto Ricans, insignificant when the number of comparisons was taken into account. We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200306-877OC</identifier><identifier>PMID: 12958057</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>ADAM Proteins ; Adolescent ; Asthma ; Asthma - blood ; Asthma - drug therapy ; Asthma - genetics ; Biological and medical sciences ; Bronchodilator Agents - administration & dosage ; Case-Control Studies ; Child ; Chronic obstructive pulmonary disease, asthma ; Ethnicity ; Families & family life ; Female ; Genetics ; Genotype ; Haplotypes ; Hispanic Americans - genetics ; Humans ; Immunoglobulin E - blood ; Male ; Medical sciences ; Metalloendopeptidases - genetics ; Mexican Americans - genetics ; Mortality ; Pneumology ; Polymerase chain reaction ; Polymorphism, Single Nucleotide - genetics ; Questionnaires ; Severity of Illness Index</subject><ispartof>American journal of respiratory and critical care medicine, 2003-12, Vol.168 (11), p.1312-1316</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Thoracic Society Dec 1, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-bd0d7c16096fcc0e6258cc9bca34718439e38fbd528784421206cab7fc4915d03</citedby><cites>FETCH-LOGICAL-c390t-bd0d7c16096fcc0e6258cc9bca34718439e38fbd528784421206cab7fc4915d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,4011,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15321058$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12958057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lind, Denise L</creatorcontrib><creatorcontrib>Choudhry, Shweta</creatorcontrib><creatorcontrib>Ung, Ngim</creatorcontrib><creatorcontrib>Ziv, Elad</creatorcontrib><creatorcontrib>Avila, Pedro C</creatorcontrib><creatorcontrib>Salari, Keyan</creatorcontrib><creatorcontrib>Ha, Connie</creatorcontrib><creatorcontrib>Lovins, Elizabeth G</creatorcontrib><creatorcontrib>Coyle, Natasha E</creatorcontrib><creatorcontrib>Nazario, Sylvette</creatorcontrib><creatorcontrib>Casal, Jesus</creatorcontrib><creatorcontrib>Torres, Alfonso</creatorcontrib><creatorcontrib>Rodriguez-Santana, Jose R</creatorcontrib><creatorcontrib>Matallana, Henry</creatorcontrib><creatorcontrib>Lilly, Craig M</creatorcontrib><creatorcontrib>Salas, Jorge</creatorcontrib><creatorcontrib>Selman, Moises</creatorcontrib><creatorcontrib>Boushey, Homer A</creatorcontrib><creatorcontrib>Weiss, Scott T</creatorcontrib><creatorcontrib>Chapela, Rocio</creatorcontrib><creatorcontrib>Ford, Jean G</creatorcontrib><creatorcontrib>Rodriguez-Cintron, William</creatorcontrib><creatorcontrib>Silverman, Edwin K</creatorcontrib><creatorcontrib>Sheppard, Dean</creatorcontrib><creatorcontrib>Kwok, Pui-Yan</creatorcontrib><creatorcontrib>Burchard, Esteban Gonzalez</creatorcontrib><title>ADAM33 Is Not Associated with Asthma in Puerto Rican or Mexican Populations</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>A recent study identified the ADAM33 gene as a promising candidate contributing to asthma. In Puerto Rican and Mexican populations, we have genotyped six single nucleotide polymorphisms (SNPs) that were used in the Genetics of Asthma in Latino Americans Study. We chose to study these two populations because in the United States, Puerto Ricans have the highest asthma prevalence, morbidity, and mortality and Mexicans the lowest. We used the transmission disequilibrium test to analyze associations between the ADAM33 gene variants and asthma, asthma severity, bronchodilator responsiveness, and total IgE levels using single SNPs, two to six SNP combinations, and specific haplotypes in 583 trios (proband with asthma and both biological parents). We also genotyped matched control samples to allow case-control analyses. None of the transmission disequilibrium test or case-control results showed significant association in either population. We found no evidence for association of single SNPs with asthma severity, bronchodilator response, or IgE levels in Mexicans or in the combined population. Two SNPs showed a modest association in Puerto Ricans, insignificant when the number of comparisons was taken into account. We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans.</description><subject>ADAM Proteins</subject><subject>Adolescent</subject><subject>Asthma</subject><subject>Asthma - blood</subject><subject>Asthma - drug therapy</subject><subject>Asthma - genetics</subject><subject>Biological and medical sciences</subject><subject>Bronchodilator Agents - administration & dosage</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Ethnicity</subject><subject>Families & family life</subject><subject>Female</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Hispanic Americans - genetics</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metalloendopeptidases - genetics</subject><subject>Mexican Americans - genetics</subject><subject>Mortality</subject><subject>Pneumology</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Questionnaires</subject><subject>Severity of Illness Index</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkN9rFDEQxxdRbK3-Ab5IEPRFts7kxyZ5PM5fxdYWUfAtZLNZL8fu5prsUv3vzfUOCj7NDHzmO8Onql4inCM2_H1ybjynAAyaWkl5vX5UnaJgouZawuPSg2Q15_rXSfUs5y0AUoXwtDpBqoUCIU-rr6sPqyvGyEUm3-JMVjlHF-zsO3IX5k2Z581oSZjIzeLTHMn34OxEYiJX_s99exN3y2DnEKf8vHrS2yH7F8d6Vv389PHH-kt9ef35Yr26rB3TMNdtB5102IBueufAN1Qo53TrLOMSFWfaM9W3naBKKs4pUmicbWXvuEbRATur3h5ydyneLj7PZgzZ-WGwk49LNhI5IipdwNf_gdu4pKn8ZlBryVTDVIHwALkUc06-N7sURpv-GgSz12z2ms1Bs7nXXHZeHYOXdvTdw8bRawHeHAGbnR36ZCcX8gMnGEUQ--PvDtwm_N7cheRNHu0wlFg0drs_jI0qXxhkSNk_dqaSaw</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Lind, Denise L</creator><creator>Choudhry, Shweta</creator><creator>Ung, Ngim</creator><creator>Ziv, Elad</creator><creator>Avila, Pedro C</creator><creator>Salari, Keyan</creator><creator>Ha, Connie</creator><creator>Lovins, Elizabeth G</creator><creator>Coyle, Natasha E</creator><creator>Nazario, Sylvette</creator><creator>Casal, Jesus</creator><creator>Torres, Alfonso</creator><creator>Rodriguez-Santana, Jose R</creator><creator>Matallana, Henry</creator><creator>Lilly, Craig M</creator><creator>Salas, Jorge</creator><creator>Selman, Moises</creator><creator>Boushey, Homer A</creator><creator>Weiss, Scott T</creator><creator>Chapela, Rocio</creator><creator>Ford, Jean G</creator><creator>Rodriguez-Cintron, William</creator><creator>Silverman, Edwin K</creator><creator>Sheppard, Dean</creator><creator>Kwok, Pui-Yan</creator><creator>Burchard, Esteban Gonzalez</creator><general>Am Thoracic Soc</general><general>American Lung Association</general><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>ADAM33 Is Not Associated with Asthma in Puerto Rican or Mexican Populations</title><author>Lind, Denise L ; Choudhry, Shweta ; Ung, Ngim ; Ziv, Elad ; Avila, Pedro C ; Salari, Keyan ; Ha, Connie ; Lovins, Elizabeth G ; Coyle, Natasha E ; Nazario, Sylvette ; Casal, Jesus ; Torres, Alfonso ; Rodriguez-Santana, Jose R ; Matallana, Henry ; Lilly, Craig M ; Salas, Jorge ; Selman, Moises ; Boushey, Homer A ; Weiss, Scott T ; Chapela, Rocio ; Ford, Jean G ; Rodriguez-Cintron, William ; Silverman, Edwin K ; Sheppard, Dean ; Kwok, Pui-Yan ; Burchard, Esteban Gonzalez</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-bd0d7c16096fcc0e6258cc9bca34718439e38fbd528784421206cab7fc4915d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>ADAM Proteins</topic><topic>Adolescent</topic><topic>Asthma</topic><topic>Asthma - 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Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lind, Denise L</au><au>Choudhry, Shweta</au><au>Ung, Ngim</au><au>Ziv, Elad</au><au>Avila, Pedro C</au><au>Salari, Keyan</au><au>Ha, Connie</au><au>Lovins, Elizabeth G</au><au>Coyle, Natasha E</au><au>Nazario, Sylvette</au><au>Casal, Jesus</au><au>Torres, Alfonso</au><au>Rodriguez-Santana, Jose R</au><au>Matallana, Henry</au><au>Lilly, Craig M</au><au>Salas, Jorge</au><au>Selman, Moises</au><au>Boushey, Homer A</au><au>Weiss, Scott T</au><au>Chapela, Rocio</au><au>Ford, Jean G</au><au>Rodriguez-Cintron, William</au><au>Silverman, Edwin K</au><au>Sheppard, Dean</au><au>Kwok, Pui-Yan</au><au>Burchard, Esteban Gonzalez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ADAM33 Is Not Associated with Asthma in Puerto Rican or Mexican Populations</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>168</volume><issue>11</issue><spage>1312</spage><epage>1316</epage><pages>1312-1316</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>A recent study identified the ADAM33 gene as a promising candidate contributing to asthma. In Puerto Rican and Mexican populations, we have genotyped six single nucleotide polymorphisms (SNPs) that were used in the Genetics of Asthma in Latino Americans Study. We chose to study these two populations because in the United States, Puerto Ricans have the highest asthma prevalence, morbidity, and mortality and Mexicans the lowest. We used the transmission disequilibrium test to analyze associations between the ADAM33 gene variants and asthma, asthma severity, bronchodilator responsiveness, and total IgE levels using single SNPs, two to six SNP combinations, and specific haplotypes in 583 trios (proband with asthma and both biological parents). We also genotyped matched control samples to allow case-control analyses. None of the transmission disequilibrium test or case-control results showed significant association in either population. We found no evidence for association of single SNPs with asthma severity, bronchodilator response, or IgE levels in Mexicans or in the combined population. Two SNPs showed a modest association in Puerto Ricans, insignificant when the number of comparisons was taken into account. We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>12958057</pmid><doi>10.1164/rccm.200306-877OC</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2003-12, Vol.168 (11), p.1312-1316 |
| issn | 1073-449X 1535-4970 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online |
| subjects | ADAM Proteins Adolescent Asthma Asthma - blood Asthma - drug therapy Asthma - genetics Biological and medical sciences Bronchodilator Agents - administration & dosage Case-Control Studies Child Chronic obstructive pulmonary disease, asthma Ethnicity Families & family life Female Genetics Genotype Haplotypes Hispanic Americans - genetics Humans Immunoglobulin E - blood Male Medical sciences Metalloendopeptidases - genetics Mexican Americans - genetics Mortality Pneumology Polymerase chain reaction Polymorphism, Single Nucleotide - genetics Questionnaires Severity of Illness Index |
| title | ADAM33 Is Not Associated with Asthma in Puerto Rican or Mexican Populations |
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