Slit1 and Slit2 Cooperate to Prevent Premature Midline Crossing of Retinal Axons in the Mouse Visual System

During development, retinal ganglion cell (RGC) axons either cross or avoid the midline at the optic chiasm. In Drosophila, the Slit protein regulates midline axon crossing through repulsion. To determine the role of Slit proteins in RGC axon guidance, we disrupted Slit1 and Slit2, two of three know...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2002-01, Vol.33 (2), p.219-232
Hauptverfasser:	Plump, Andrew S., Erskine, Lynda, Sabatier, Christelle, Brose, Katja, Epstein, Charles J., Goodman, Corey S., Mason, Carol A., Tessier-Lavigne, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - physiology Brain Defects Diencephalon - embryology Embryonic and Fetal Development - physiology Insects Intercellular Signaling Peptides and Proteins Ligands Mammals Mice Mice, Knockout - genetics Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neural Inhibition - physiology Optic Chiasm - embryology Optic nerve Preoptic Area - embryology Proteins Retina Retina - embryology Retinal Ganglion Cells - physiology Slit protein Synaptic Transmission - physiology Visual Pathways - embryology
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