Effects of tibolone on thromboxane B(2) levels in postmenopausal women
This study was carried out in 16 premenopausal (control) and 24 postmenopausal women (study group) to investigate the effect of menopause and tibolone treatment (2.5 mg/day for 6 months) on plasma thromboxane B(2) (TxB(2)), a well-known vasoconstrictor and stimulator of platelet aggregation. The TxB...
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| Veröffentlicht in: | Gynecologic and obstetric investigation 2002, Vol.53 (1), p.13-15 |
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| container_title | Gynecologic and obstetric investigation |
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| creator | Canbaz, Mukaddes Vural, Pervin Akgül, Cemil |
| description | This study was carried out in 16 premenopausal (control) and 24 postmenopausal women (study group) to investigate the effect of menopause and tibolone treatment (2.5 mg/day for 6 months) on plasma thromboxane B(2) (TxB(2)), a well-known vasoconstrictor and stimulator of platelet aggregation. The TxB(2) levels were measured using [(125)I] RIA kit. Statistical significance was analyzed by Student's t test for paired and unpaired data, and Pearson's correlation analysis. Plasma TxB(2) concentrations of postmenopausal women were higher than those of premenopausal women. Tibolone treatment decreased plasma TxB(2) in postmenopausal women. There was no correlation between TxB(2) and blood pressure and heart rate. It was concluded that tibolone, decreasing the plasma concentrations of TxB(2), might have beneficial effects on prostaglandin metabolism and thus reduce the risk of cardiovascular disease. |
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The TxB(2) levels were measured using [(125)I] RIA kit. Statistical significance was analyzed by Student's t test for paired and unpaired data, and Pearson's correlation analysis. Plasma TxB(2) concentrations of postmenopausal women were higher than those of premenopausal women. Tibolone treatment decreased plasma TxB(2) in postmenopausal women. There was no correlation between TxB(2) and blood pressure and heart rate. It was concluded that tibolone, decreasing the plasma concentrations of TxB(2), might have beneficial effects on prostaglandin metabolism and thus reduce the risk of cardiovascular disease.</description><identifier>ISSN: 0378-7346</identifier><identifier>PMID: 11803222</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Adult ; Cardiovascular Diseases ; Estrogen Receptor Modulators - pharmacology ; Estrogen Replacement Therapy ; Female ; Humans ; Middle Aged ; Norpregnenes - pharmacology ; Oxidative Stress ; Postmenopause ; Premenopause ; Thromboxane B2 - blood</subject><ispartof>Gynecologic and obstetric investigation, 2002, Vol.53 (1), p.13-15</ispartof><rights>Copyright 2002 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11803222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Canbaz, Mukaddes</creatorcontrib><creatorcontrib>Vural, Pervin</creatorcontrib><creatorcontrib>Akgül, Cemil</creatorcontrib><title>Effects of tibolone on thromboxane B(2) levels in postmenopausal women</title><title>Gynecologic and obstetric investigation</title><addtitle>Gynecol Obstet Invest</addtitle><description>This study was carried out in 16 premenopausal (control) and 24 postmenopausal women (study group) to investigate the effect of menopause and tibolone treatment (2.5 mg/day for 6 months) on plasma thromboxane B(2) (TxB(2)), a well-known vasoconstrictor and stimulator of platelet aggregation. The TxB(2) levels were measured using [(125)I] RIA kit. Statistical significance was analyzed by Student's t test for paired and unpaired data, and Pearson's correlation analysis. Plasma TxB(2) concentrations of postmenopausal women were higher than those of premenopausal women. Tibolone treatment decreased plasma TxB(2) in postmenopausal women. There was no correlation between TxB(2) and blood pressure and heart rate. 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The TxB(2) levels were measured using [(125)I] RIA kit. Statistical significance was analyzed by Student's t test for paired and unpaired data, and Pearson's correlation analysis. Plasma TxB(2) concentrations of postmenopausal women were higher than those of premenopausal women. Tibolone treatment decreased plasma TxB(2) in postmenopausal women. There was no correlation between TxB(2) and blood pressure and heart rate. It was concluded that tibolone, decreasing the plasma concentrations of TxB(2), might have beneficial effects on prostaglandin metabolism and thus reduce the risk of cardiovascular disease.</abstract><cop>Switzerland</cop><pmid>11803222</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Gynecologic and obstetric investigation, 2002, Vol.53 (1), p.13-15 |
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| language | eng |
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| source | Karger Journals; MEDLINE |
| subjects | Adult Cardiovascular Diseases Estrogen Receptor Modulators - pharmacology Estrogen Replacement Therapy Female Humans Middle Aged Norpregnenes - pharmacology Oxidative Stress Postmenopause Premenopause Thromboxane B2 - blood |
| title | Effects of tibolone on thromboxane B(2) levels in postmenopausal women |
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