Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: Therapeutic implications

Methylphenidate (Ritalin) is an effective drug in the treatment of attention deficit hyperactivity disorder. However, the doses required therapeutically vary significantly between subjects and it is not understood what determines these differences. Since methylphenidate's therapeutic effects ar...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2002-03, Vol.43 (3), p.181-187
Hauptverfasser:	Volkow, Nora D., Wang, Gene-Jack, Fowler, Joanna S., Logan, Jean, Franceschi, Dinko, Maynard, Laurence, Ding, Yu-Shin, Gatley, Samuel J., Gifford, Andrew, Zhu, Wei, Swanson, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Age Factors Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - metabolism Attention Deficit Disorder with Hyperactivity - physiopathology attention deficit hyperactivity disorder Behavior - drug effects Behavior - physiology Brain - diagnostic imaging Brain - drug effects Carbon Radioisotopes - metabolism Cardiovascular Physiological Phenomena - drug effects Cocaine - metabolism DA receptors Dopamine - metabolism Dopamine - secretion Dopamine Antagonists - metabolism Dopamine Plasma Membrane Transport Proteins Dopamine Uptake Inhibitors - pharmacology Extracellular Space - drug effects Extracellular Space - metabolism Humans imaging Male Membrane Glycoproteins Membrane Transport Modulators Membrane Transport Proteins - antagonists & inhibitors Membrane Transport Proteins - metabolism methylphenidate Methylphenidate - blood Methylphenidate - pharmacology Neostriatum - diagnostic imaging Neostriatum - drug effects Nerve Tissue Proteins Neurons - drug effects Neurons - metabolism raclopride Raclopride - metabolism Ritalin striatum Tomography, Emission-Computed Up-Regulation - drug effects Up-Regulation - physiology
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