Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors

While estrogen-related receptors (ERRalpha, ERRbeta, and ERRgamma) share a high amino acid sequence homology with estrogen receptors (ERs), estrogens are not ligands of ERRs. Structure-function studies from this and other laboratories have revealed that ERRs have small ligand-binding pockets and hav...

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Veröffentlicht in:	Molecular cancer research 2003-11, Vol.1 (13), p.981-991
Hauptverfasser:	Suetsugi, Masatomo, Su, Leila, Karlsberg, Kimberly, Yuan, Yate-Ching, Chen, Shiuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive Computer Simulation Databases, Factual ERRalpha Estrogen-Related Receptor Flavones Flavonoids - chemistry Flavonoids - pharmacology Genistein - chemistry Genistein - pharmacology HeLa Cells Humans Isoflavones - chemistry Isoflavones - pharmacology Ligands Luciferases - genetics Luciferases - metabolism Models, Molecular Molecular Structure Phytoestrogens Plant Preparations - chemistry Plant Preparations - pharmacology Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - genetics Receptors, Estrogen - agonists Receptors, Estrogen - chemistry Receptors, Estrogen - genetics Recombinant Fusion Proteins - drug effects Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Structure-Activity Relationship Transfection
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