Time Course and Mechanisms of Phosphorylation of Phospholamban Residues in Ischemia-reperfused Rat Hearts. Dissociation of Phospholamban Phosphorylation Pathways

Sarcoplasmic reticulum (SR) dysfunction is one of the multiple alterations that occurs in ischemia-reperfused hearts. Because SR function is regulated by phosphorylation of phospholamban (PLB), a SR protein phosphorylated by cAMP-dependent protein kinase (PKA) at Ser16and Ca2+-calmodulin-dependent p...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2002-01, Vol.34 (1), p.39-50
Hauptverfasser:	Vittone, Leticia, Mundiña-Weilenmann, Cecilia, Said, Matilde, Ferrero, Paola, Mattiazzi, Alicia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Calcium - metabolism Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - metabolism Cardiac sarcoplasmic reticulum Catecholamines - pharmacology Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Electrophoresis, Polyacrylamide Gel Enzyme Inhibitors - pharmacology Heart - physiology Ischemia - metabolism Ischemia-reperfusion Isolated rat heart Male Myocardium - metabolism Phospholamban phosphorylation Phosphorylation Rats Rats, Wistar Receptors, Adrenergic, beta - metabolism Reperfusion Injury Sarcoplasmic Reticulum - metabolism Serine - chemistry Serine - metabolism Sodium-Calcium Exchanger - metabolism Thiourea - analogs & derivatives Thiourea - pharmacology Threonine - chemistry Threonine - metabolism Time Factors
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