Use of a lentiviral flap vector for induction of CTL immunity against melanoma. Perspectives for immunotherapy

Background A central triple‐stranded DNA structure created during HIV‐1 reverse transcription, the central flap, acts as a cis‐active nuclear import determinant of the HIV‐1 DNA genome. Insertion of the sequences responsible for formation of the central DNA flap into an HIV‐1‐derived vector strongly...

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