Differential regulation of L1 and L2 β-lactamase expression in Stenotrophomonas maltophilia

It has been reported that Stenotrophomonas maltophilia L1 and L2 β-lactamase expression is coordinated. We have isolated S. maltophilia mutants where (i) L1 is constitutively hyper-expressed and L2 is inducible; (ii) L2 is hyper-expressed and L1 is inducible; and (iii) L1 and L2 are constitutively h...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2002-02, Vol.49 (2), p.387-389
Hauptverfasser:	Avison, Matthew B., Higgins, Catherine S., Ford, Peter J., von Heldreich, Charlotte J., Walsh, Timothy R., Bennett, Peter M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteriology beta-Lactamases - biosynthesis beta-Lactamases - genetics Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - genetics Genetics Humans Medical sciences Metabolism. Enzymes Microbiology Mutation Pharmacology. Drug treatments Stenotrophomonas maltophilia - enzymology Stenotrophomonas maltophilia - genetics Stenotrophomonas maltophilia - isolation & purification
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