Differential regulation of L1 and L2 β-lactamase expression in Stenotrophomonas maltophilia
It has been reported that Stenotrophomonas maltophilia L1 and L2 β-lactamase expression is coordinated. We have isolated S. maltophilia mutants where (i) L1 is constitutively hyper-expressed and L2 is inducible; (ii) L2 is hyper-expressed and L1 is inducible; and (iii) L1 and L2 are constitutively h...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2002-02, Vol.49 (2), p.387-389 |
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| container_issue | 2 |
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| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 49 |
| creator | Avison, Matthew B. Higgins, Catherine S. Ford, Peter J. von Heldreich, Charlotte J. Walsh, Timothy R. Bennett, Peter M. |
| description | It has been reported that Stenotrophomonas maltophilia L1 and L2 β-lactamase expression is coordinated. We have isolated S. maltophilia mutants where (i) L1 is constitutively hyper-expressed and L2 is inducible; (ii) L2 is hyper-expressed and L1 is inducible; and (iii) L1 and L2 are constitutively hyper-expressed. The frequency of isolating type 1 and 2 mutants is c. 10−7, indicating that promoter mutations are probably not involved and providing strong evidence that L1 and L2 expression is not, after all, coordinated. The frequency of isolating type 3 mutants is c. 10−9, however, implying that there is a significant overlap between the regulatory mechanisms. |
| doi_str_mv | 10.1093/jac/49.2.387 |
| format | Article |
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We have isolated S. maltophilia mutants where (i) L1 is constitutively hyper-expressed and L2 is inducible; (ii) L2 is hyper-expressed and L1 is inducible; and (iii) L1 and L2 are constitutively hyper-expressed. The frequency of isolating type 1 and 2 mutants is c. 10−7, indicating that promoter mutations are probably not involved and providing strong evidence that L1 and L2 expression is not, after all, coordinated. The frequency of isolating type 3 mutants is c. 10−9, however, implying that there is a significant overlap between the regulatory mechanisms.</description><identifier>ISSN: 0305-7453</identifier><identifier>ISSN: 1460-2091</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/49.2.387</identifier><identifier>PMID: 11815585</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacteriology ; beta-Lactamases - biosynthesis ; beta-Lactamases - genetics ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Enzymologic - genetics ; Genetics ; Humans ; Medical sciences ; Metabolism. Enzymes ; Microbiology ; Mutation ; Pharmacology. Drug treatments ; Stenotrophomonas maltophilia - enzymology ; Stenotrophomonas maltophilia - genetics ; Stenotrophomonas maltophilia - isolation & purification</subject><ispartof>Journal of antimicrobial chemotherapy, 2002-02, Vol.49 (2), p.387-389</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-9355fe3221c7be275feebabce9531e5ae3740f249547950591c65cd0fb8e69403</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13751290$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11815585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avison, Matthew B.</creatorcontrib><creatorcontrib>Higgins, Catherine S.</creatorcontrib><creatorcontrib>Ford, Peter J.</creatorcontrib><creatorcontrib>von Heldreich, Charlotte J.</creatorcontrib><creatorcontrib>Walsh, Timothy R.</creatorcontrib><creatorcontrib>Bennett, Peter M.</creatorcontrib><title>Differential regulation of L1 and L2 β-lactamase expression in Stenotrophomonas maltophilia</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J. Antimicrob. Chemother</addtitle><description>It has been reported that Stenotrophomonas maltophilia L1 and L2 β-lactamase expression is coordinated. We have isolated S. maltophilia mutants where (i) L1 is constitutively hyper-expressed and L2 is inducible; (ii) L2 is hyper-expressed and L1 is inducible; and (iii) L1 and L2 are constitutively hyper-expressed. The frequency of isolating type 1 and 2 mutants is c. 10−7, indicating that promoter mutations are probably not involved and providing strong evidence that L1 and L2 expression is not, after all, coordinated. The frequency of isolating type 3 mutants is c. 10−9, however, implying that there is a significant overlap between the regulatory mechanisms.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteriology</subject><subject>beta-Lactamases - biosynthesis</subject><subject>beta-Lactamases - genetics</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Enzymologic - genetics</subject><subject>Genetics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Metabolism. Enzymes</subject><subject>Microbiology</subject><subject>Mutation</subject><subject>Pharmacology. Drug treatments</subject><subject>Stenotrophomonas maltophilia - enzymology</subject><subject>Stenotrophomonas maltophilia - genetics</subject><subject>Stenotrophomonas maltophilia - isolation & purification</subject><issn>0305-7453</issn><issn>1460-2091</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MGKFDEQgOEgijuu3jxLLu7Jnk06SXdydFbdFQcVVBARQnWmolnT3WOSgfW1fBCfyQwzuEdPochHQf2EPOZsyZkR59fgzqVZtkuh-ztkwWXHmpYZfpcsmGCq6aUSJ-RBzteMsU51-j454VxzpbRakK8vgveYcCoBIk34bRehhHmis6drTmHa0HVL__xuIrgCI2SkeLNNmPMehYl-KDjNJc3b7_M4T5DpCLHUKcQAD8k9DzHjo-N7Sj69evnx4qpZv7t8ffF83Tihu9IYoZRH0bbc9QO2fR1wgMGhUYKjAhS9ZL6VRsneKKYMd51yG-YHjZ2RTJySs8PebZp_7jAXO4bsMEaYcN5l23PJtK6x_ge5VkZIISp8doAuzTkn9Habwgjpl-XM7rPbmt1KY1tbs1f-5Lh3N4y4ucXHzhU8PQLIDqJPMLmQb53oFW_N_pLm4EIuePPvH9IP2_UV2avPX-z71Uq_Xb2R9lL8BSTzmrc</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>Avison, Matthew B.</creator><creator>Higgins, Catherine S.</creator><creator>Ford, Peter J.</creator><creator>von Heldreich, Charlotte J.</creator><creator>Walsh, Timothy R.</creator><creator>Bennett, Peter M.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20020201</creationdate><title>Differential regulation of L1 and L2 β-lactamase expression in Stenotrophomonas maltophilia</title><author>Avison, Matthew B. ; Higgins, Catherine S. ; Ford, Peter J. ; von Heldreich, Charlotte J. ; Walsh, Timothy R. ; Bennett, Peter M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-9355fe3221c7be275feebabce9531e5ae3740f249547950591c65cd0fb8e69403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacteriology</topic><topic>beta-Lactamases - biosynthesis</topic><topic>beta-Lactamases - genetics</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Enzymologic - genetics</topic><topic>Genetics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Metabolism. Enzymes</topic><topic>Microbiology</topic><topic>Mutation</topic><topic>Pharmacology. Drug treatments</topic><topic>Stenotrophomonas maltophilia - enzymology</topic><topic>Stenotrophomonas maltophilia - genetics</topic><topic>Stenotrophomonas maltophilia - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avison, Matthew B.</creatorcontrib><creatorcontrib>Higgins, Catherine S.</creatorcontrib><creatorcontrib>Ford, Peter J.</creatorcontrib><creatorcontrib>von Heldreich, Charlotte J.</creatorcontrib><creatorcontrib>Walsh, Timothy R.</creatorcontrib><creatorcontrib>Bennett, Peter M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avison, Matthew B.</au><au>Higgins, Catherine S.</au><au>Ford, Peter J.</au><au>von Heldreich, Charlotte J.</au><au>Walsh, Timothy R.</au><au>Bennett, Peter M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential regulation of L1 and L2 β-lactamase expression in Stenotrophomonas maltophilia</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J. Antimicrob. Chemother</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>49</volume><issue>2</issue><spage>387</spage><epage>389</epage><pages>387-389</pages><issn>0305-7453</issn><issn>1460-2091</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>It has been reported that Stenotrophomonas maltophilia L1 and L2 β-lactamase expression is coordinated. We have isolated S. maltophilia mutants where (i) L1 is constitutively hyper-expressed and L2 is inducible; (ii) L2 is hyper-expressed and L1 is inducible; and (iii) L1 and L2 are constitutively hyper-expressed. The frequency of isolating type 1 and 2 mutants is c. 10−7, indicating that promoter mutations are probably not involved and providing strong evidence that L1 and L2 expression is not, after all, coordinated. The frequency of isolating type 3 mutants is c. 10−9, however, implying that there is a significant overlap between the regulatory mechanisms.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11815585</pmid><doi>10.1093/jac/49.2.387</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Free Full-Text Journals in Chemistry |
| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteriology beta-Lactamases - biosynthesis beta-Lactamases - genetics Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - genetics Genetics Humans Medical sciences Metabolism. Enzymes Microbiology Mutation Pharmacology. Drug treatments Stenotrophomonas maltophilia - enzymology Stenotrophomonas maltophilia - genetics Stenotrophomonas maltophilia - isolation & purification |
| title | Differential regulation of L1 and L2 β-lactamase expression in Stenotrophomonas maltophilia |
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