ACE I/D polymorphism and cardiac adaptations in adolescent athletes
The aim of this cross-sectional study was to determine whether there is a correlation between left ventricular hypertrophy (LVH) and angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism in adolescent athletes. Seventy-five competitive soccer players (aged 15 +/- 1.2 yr) and 52 u...
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| Veröffentlicht in: | Medicine and science in sports and exercise 2003-12, Vol.35 (12), p.1986-1990 |
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| container_end_page | 1990 |
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| container_issue | 12 |
| container_start_page | 1986 |
| container_title | Medicine and science in sports and exercise |
| container_volume | 35 |
| creator | RIZZO, Marta GENSINI, Francesca FATINI, Cinzia MANETTI, Paolo PUCCI, Nicola CAPALBO, Andrea VONO, Maria Concetta GALANTI, Giorgio |
| description | The aim of this cross-sectional study was to determine whether there is a correlation between left ventricular hypertrophy (LVH) and angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism in adolescent athletes.
Seventy-five competitive soccer players (aged 15 +/- 1.2 yr) and 52 untrained control subjects (aged 15 +/- 1.6 yr) were examined with echocardiography (echo) and bioelectrical impedance analysis. The ACE genotype of all subjects was determined by PCR and correlated with left ventricular mass (LVM) indices.
Allele frequencies were comparable between athletes and controls. Body surface area (BSA), fat-free mass (FFM), and all mean echo measurements were significantly greater in athletes than in controls. LVM and LVM indices for both BSA and FFM were all significantly greater in athletes than in controls (LVM 195.3 +/- 32 g vs 165.3 +/- 37.6 g; LVM/BSA 115.5 +/- 18.9 g x mq(-1) vs 95 +/- 18.2 g x mq(-1); LVM/FFM 3.5 +/- 0.5 vs 3 +/- 0.54, P < 0.001 for the three variables). Left ventricular hypertrophy was found in 17 (23%) athletes. There was no correlation between ACE I/D polymorphism and athletes with LVH as the II and DD genotype frequencies were identical (41%). However, in athletes with LVH, the presence of the D allele was associated with a greater LVM index than compared to homozygous II genotype (LVM = 145 +/- 7.6 g x mq(-1) in DD+ID group vs 135 +/- 2.9 g x mq(-1) in II group, P = 0.008).
The results of the study show that significant changes occur in cardiac morphology and function in adolescent athletes. Interestingly, the ACE I/D polymorphism was associated with the degree of cardiac hypertrophy but not with the occurrence of LVH itself. |
| doi_str_mv | 10.1249/01.MSS.0000098993.51693.0B |
| format | Article |
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Seventy-five competitive soccer players (aged 15 +/- 1.2 yr) and 52 untrained control subjects (aged 15 +/- 1.6 yr) were examined with echocardiography (echo) and bioelectrical impedance analysis. The ACE genotype of all subjects was determined by PCR and correlated with left ventricular mass (LVM) indices.
Allele frequencies were comparable between athletes and controls. Body surface area (BSA), fat-free mass (FFM), and all mean echo measurements were significantly greater in athletes than in controls. LVM and LVM indices for both BSA and FFM were all significantly greater in athletes than in controls (LVM 195.3 +/- 32 g vs 165.3 +/- 37.6 g; LVM/BSA 115.5 +/- 18.9 g x mq(-1) vs 95 +/- 18.2 g x mq(-1); LVM/FFM 3.5 +/- 0.5 vs 3 +/- 0.54, P < 0.001 for the three variables). Left ventricular hypertrophy was found in 17 (23%) athletes. There was no correlation between ACE I/D polymorphism and athletes with LVH as the II and DD genotype frequencies were identical (41%). However, in athletes with LVH, the presence of the D allele was associated with a greater LVM index than compared to homozygous II genotype (LVM = 145 +/- 7.6 g x mq(-1) in DD+ID group vs 135 +/- 2.9 g x mq(-1) in II group, P = 0.008).
The results of the study show that significant changes occur in cardiac morphology and function in adolescent athletes. Interestingly, the ACE I/D polymorphism was associated with the degree of cardiac hypertrophy but not with the occurrence of LVH itself.</description><identifier>ISSN: 0195-9131</identifier><identifier>EISSN: 1530-0315</identifier><identifier>DOI: 10.1249/01.MSS.0000098993.51693.0B</identifier><identifier>PMID: 14652492</identifier><identifier>CODEN: MSPEDA</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Biological and medical sciences ; Child ; Cross-Sectional Studies ; Echocardiography ; Electric Impedance ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypertrophy, Left Ventricular - diagnostic imaging ; Hypertrophy, Left Ventricular - enzymology ; Hypertrophy, Left Ventricular - genetics ; Hypertrophy, Left Ventricular - physiopathology ; Peptidyl-Dipeptidase A - genetics ; Polymorphism, Genetic ; Receptor, Angiotensin, Type 1 - genetics ; Receptors, Angiotensin - genetics ; Space life sciences ; Sports - physiology ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><ispartof>Medicine and science in sports and exercise, 2003-12, Vol.35 (12), p.1986-1990</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-65242ca4ad1319b3d71a28768e0cecdfdb1bac3c5a14435a813dd439209e13273</citedby><cites>FETCH-LOGICAL-c397t-65242ca4ad1319b3d71a28768e0cecdfdb1bac3c5a14435a813dd439209e13273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15357830$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14652492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RIZZO, Marta</creatorcontrib><creatorcontrib>GENSINI, Francesca</creatorcontrib><creatorcontrib>FATINI, Cinzia</creatorcontrib><creatorcontrib>MANETTI, Paolo</creatorcontrib><creatorcontrib>PUCCI, Nicola</creatorcontrib><creatorcontrib>CAPALBO, Andrea</creatorcontrib><creatorcontrib>VONO, Maria Concetta</creatorcontrib><creatorcontrib>GALANTI, Giorgio</creatorcontrib><title>ACE I/D polymorphism and cardiac adaptations in adolescent athletes</title><title>Medicine and science in sports and exercise</title><addtitle>Med Sci Sports Exerc</addtitle><description>The aim of this cross-sectional study was to determine whether there is a correlation between left ventricular hypertrophy (LVH) and angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism in adolescent athletes.
Seventy-five competitive soccer players (aged 15 +/- 1.2 yr) and 52 untrained control subjects (aged 15 +/- 1.6 yr) were examined with echocardiography (echo) and bioelectrical impedance analysis. The ACE genotype of all subjects was determined by PCR and correlated with left ventricular mass (LVM) indices.
Allele frequencies were comparable between athletes and controls. Body surface area (BSA), fat-free mass (FFM), and all mean echo measurements were significantly greater in athletes than in controls. LVM and LVM indices for both BSA and FFM were all significantly greater in athletes than in controls (LVM 195.3 +/- 32 g vs 165.3 +/- 37.6 g; LVM/BSA 115.5 +/- 18.9 g x mq(-1) vs 95 +/- 18.2 g x mq(-1); LVM/FFM 3.5 +/- 0.5 vs 3 +/- 0.54, P < 0.001 for the three variables). Left ventricular hypertrophy was found in 17 (23%) athletes. There was no correlation between ACE I/D polymorphism and athletes with LVH as the II and DD genotype frequencies were identical (41%). However, in athletes with LVH, the presence of the D allele was associated with a greater LVM index than compared to homozygous II genotype (LVM = 145 +/- 7.6 g x mq(-1) in DD+ID group vs 135 +/- 2.9 g x mq(-1) in II group, P = 0.008).
The results of the study show that significant changes occur in cardiac morphology and function in adolescent athletes. Interestingly, the ACE I/D polymorphism was associated with the degree of cardiac hypertrophy but not with the occurrence of LVH itself.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Echocardiography</subject><subject>Electric Impedance</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>Hypertrophy, Left Ventricular - enzymology</subject><subject>Hypertrophy, Left Ventricular - genetics</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Receptor, Angiotensin, Type 1 - genetics</subject><subject>Receptors, Angiotensin - genetics</subject><subject>Space life sciences</subject><subject>Sports - physiology</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><issn>0195-9131</issn><issn>1530-0315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPwkAQgDdGI4j-BdOY6K2w0-nSrjdAVBKMB_S8me5uQ01fdsuBf-8iJMxhJpN888jH2APwMUSxnHAYf2w2Y34ImUqJYwFTn_n8gg1BIA85grhkQw5ShBIQBuzGuR-PJ4hwzQYQT4XfFA3ZYrZYBqvJS9A25b5qunZbuCqg2gSaOlOQDshQ21NfNLULitq3TWmdtnUfUL8tbW_dLbvKqXT27lRH7Pt1-bV4D9efb6vFbB1qlEkfHk5GmmIy_iOZoUmAojSZppZrq01uMshIoxYEcYyCUkBjYpQRlxYwSnDEno5726753VnXq6rwn5Ql1bbZOZVAzNMEYw8-H0HdNc51NldtV1TU7RVwdVCoOCivUJ0Vqn-Fis_98P3pyi6rrDmPnpx54PEEkNNU5h3VunBnTqBIUuT4B73zeSA</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>RIZZO, Marta</creator><creator>GENSINI, Francesca</creator><creator>FATINI, Cinzia</creator><creator>MANETTI, Paolo</creator><creator>PUCCI, Nicola</creator><creator>CAPALBO, Andrea</creator><creator>VONO, Maria Concetta</creator><creator>GALANTI, Giorgio</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>ACE I/D polymorphism and cardiac adaptations in adolescent athletes</title><author>RIZZO, Marta ; GENSINI, Francesca ; FATINI, Cinzia ; MANETTI, Paolo ; PUCCI, Nicola ; CAPALBO, Andrea ; VONO, Maria Concetta ; GALANTI, Giorgio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-65242ca4ad1319b3d71a28768e0cecdfdb1bac3c5a14435a813dd439209e13273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Echocardiography</topic><topic>Electric Impedance</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypertrophy, Left Ventricular - diagnostic imaging</topic><topic>Hypertrophy, Left Ventricular - enzymology</topic><topic>Hypertrophy, Left Ventricular - genetics</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Receptor, Angiotensin, Type 1 - genetics</topic><topic>Receptors, Angiotensin - genetics</topic><topic>Space life sciences</topic><topic>Sports - physiology</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIZZO, Marta</creatorcontrib><creatorcontrib>GENSINI, Francesca</creatorcontrib><creatorcontrib>FATINI, Cinzia</creatorcontrib><creatorcontrib>MANETTI, Paolo</creatorcontrib><creatorcontrib>PUCCI, Nicola</creatorcontrib><creatorcontrib>CAPALBO, Andrea</creatorcontrib><creatorcontrib>VONO, Maria Concetta</creatorcontrib><creatorcontrib>GALANTI, Giorgio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine and science in sports and exercise</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RIZZO, Marta</au><au>GENSINI, Francesca</au><au>FATINI, Cinzia</au><au>MANETTI, Paolo</au><au>PUCCI, Nicola</au><au>CAPALBO, Andrea</au><au>VONO, Maria Concetta</au><au>GALANTI, Giorgio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ACE I/D polymorphism and cardiac adaptations in adolescent athletes</atitle><jtitle>Medicine and science in sports and exercise</jtitle><addtitle>Med Sci Sports Exerc</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>35</volume><issue>12</issue><spage>1986</spage><epage>1990</epage><pages>1986-1990</pages><issn>0195-9131</issn><eissn>1530-0315</eissn><coden>MSPEDA</coden><abstract>The aim of this cross-sectional study was to determine whether there is a correlation between left ventricular hypertrophy (LVH) and angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism in adolescent athletes.
Seventy-five competitive soccer players (aged 15 +/- 1.2 yr) and 52 untrained control subjects (aged 15 +/- 1.6 yr) were examined with echocardiography (echo) and bioelectrical impedance analysis. The ACE genotype of all subjects was determined by PCR and correlated with left ventricular mass (LVM) indices.
Allele frequencies were comparable between athletes and controls. Body surface area (BSA), fat-free mass (FFM), and all mean echo measurements were significantly greater in athletes than in controls. LVM and LVM indices for both BSA and FFM were all significantly greater in athletes than in controls (LVM 195.3 +/- 32 g vs 165.3 +/- 37.6 g; LVM/BSA 115.5 +/- 18.9 g x mq(-1) vs 95 +/- 18.2 g x mq(-1); LVM/FFM 3.5 +/- 0.5 vs 3 +/- 0.54, P < 0.001 for the three variables). Left ventricular hypertrophy was found in 17 (23%) athletes. There was no correlation between ACE I/D polymorphism and athletes with LVH as the II and DD genotype frequencies were identical (41%). However, in athletes with LVH, the presence of the D allele was associated with a greater LVM index than compared to homozygous II genotype (LVM = 145 +/- 7.6 g x mq(-1) in DD+ID group vs 135 +/- 2.9 g x mq(-1) in II group, P = 0.008).
The results of the study show that significant changes occur in cardiac morphology and function in adolescent athletes. Interestingly, the ACE I/D polymorphism was associated with the degree of cardiac hypertrophy but not with the occurrence of LVH itself.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>14652492</pmid><doi>10.1249/01.MSS.0000098993.51693.0B</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Medicine and science in sports and exercise, 2003-12, Vol.35 (12), p.1986-1990 |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete |
| subjects | Adolescent Biological and medical sciences Child Cross-Sectional Studies Echocardiography Electric Impedance Fundamental and applied biological sciences. Psychology Humans Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - enzymology Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - physiopathology Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic Receptor, Angiotensin, Type 1 - genetics Receptors, Angiotensin - genetics Space life sciences Sports - physiology Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | ACE I/D polymorphism and cardiac adaptations in adolescent athletes |
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