Human neural stem cells express extra-neural markers
Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic rece...
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| Veröffentlicht in: | Brain research 2002-01, Vol.925 (2), p.213-221 |
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| container_title | Brain research |
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| creator | Parati, Eugenio A Bez, Alessandra Ponti, Dario de Grazia, Ugo Corsini, Elena Cova, Lidia Sala, Simona Colombo, Augusto Alessandri, Giulio Pagano, Stefano F |
| description | Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. This suggests that neural stem cells have a greater potential than previously thought, which involves the ability to respond to different and so far unconsidered environmental signals and may be responsible for the recently discovered process of stem cell-fate conversion. |
| doi_str_mv | 10.1016/S0006-8993(01)03291-7 |
| format | Article |
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We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. 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Teratology</subject><subject>Embryonic development</subject><subject>Endothelial receptors</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hematopoietic receptors</subject><subject>Human CNS stem cells</subject><subject>Humans</subject><subject>Molecular embryology</subject><subject>Multipotent precursors</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Platelet Endothelial Cell Adhesion Molecule-1 - analysis</subject><subject>Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis</subject><subject>Receptor Protein-Tyrosine Kinases - analysis</subject><subject>Receptor Protein-Tyrosine Kinases - biosynthesis</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>Receptor, TIE-2</subject><subject>Receptors, Growth Factor - analysis</subject><subject>Receptors, Growth Factor - biosynthesis</subject><subject>Receptors, Growth Factor - genetics</subject><subject>Receptors, Vascular Endothelial Growth Factor</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Stem Cells - chemistry</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo7rr6E5S9KHqo5rNpTiKLusKCB_UcknQC1X6sSSv67213i3v0NAx5ZvLOg9ApwdcEk_TmBWOcJplS7BKTK8yoIoncQ1OSSZqklON9NP1DJugoxve-ZUzhQzQhRCrKJJ4ivuwqU89r6IIp57GFau6gLOMcvtcB4lDbYJLxvTLhA0I8RgfelBFOxjpDbw_3r4tlsnp-fFrcrRLHKW2TVBrJrPMOckssoZYbUMKbXDjspHUqFzL3lEjrUymYzTPulKXc58qrzBM2QxfbvevQfHYQW10VcYhnami6qCXhOKNU_QuSjAklmehBsQVdaGIM4PU6FP1VP5pgPXjVG696kKYx0RuvWvZzZ-MHna0g302NInvgfARMdKb0wdSuiDuOcSGVHALcbjnovX0VEHR0BdS9oiKAa3XeFP9E-QWRf5TF</recordid><startdate>20020125</startdate><enddate>20020125</enddate><creator>Parati, Eugenio A</creator><creator>Bez, Alessandra</creator><creator>Ponti, Dario</creator><creator>de Grazia, Ugo</creator><creator>Corsini, Elena</creator><creator>Cova, Lidia</creator><creator>Sala, Simona</creator><creator>Colombo, Augusto</creator><creator>Alessandri, Giulio</creator><creator>Pagano, Stefano F</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20020125</creationdate><title>Human neural stem cells express extra-neural markers</title><author>Parati, Eugenio A ; Bez, Alessandra ; Ponti, Dario ; de Grazia, Ugo ; Corsini, Elena ; Cova, Lidia ; Sala, Simona ; Colombo, Augusto ; Alessandri, Giulio ; Pagano, Stefano F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-67a73bcfcedb1b12b4ae95fad5c0c7bc9d57df217bf6753bd84c9b24fd9f98f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antigens, CD34 - analysis</topic><topic>Antigens, CD34 - biosynthesis</topic><topic>Antigens, Differentiation - analysis</topic><topic>Antigens, Differentiation - biosynthesis</topic><topic>Antigens, Differentiation - genetics</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - physiology</topic><topic>Cells, Cultured</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic development</topic><topic>Endothelial receptors</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hematopoietic receptors</topic><topic>Human CNS stem cells</topic><topic>Humans</topic><topic>Molecular embryology</topic><topic>Multipotent precursors</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Platelet Endothelial Cell Adhesion Molecule-1 - analysis</topic><topic>Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis</topic><topic>Receptor Protein-Tyrosine Kinases - analysis</topic><topic>Receptor Protein-Tyrosine Kinases - biosynthesis</topic><topic>Receptor Protein-Tyrosine Kinases - genetics</topic><topic>Receptor, TIE-2</topic><topic>Receptors, Growth Factor - analysis</topic><topic>Receptors, Growth Factor - biosynthesis</topic><topic>Receptors, Growth Factor - genetics</topic><topic>Receptors, Vascular Endothelial Growth Factor</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Stem Cells - chemistry</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parati, Eugenio A</creatorcontrib><creatorcontrib>Bez, Alessandra</creatorcontrib><creatorcontrib>Ponti, Dario</creatorcontrib><creatorcontrib>de Grazia, Ugo</creatorcontrib><creatorcontrib>Corsini, Elena</creatorcontrib><creatorcontrib>Cova, Lidia</creatorcontrib><creatorcontrib>Sala, Simona</creatorcontrib><creatorcontrib>Colombo, Augusto</creatorcontrib><creatorcontrib>Alessandri, Giulio</creatorcontrib><creatorcontrib>Pagano, Stefano F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parati, Eugenio A</au><au>Bez, Alessandra</au><au>Ponti, Dario</au><au>de Grazia, Ugo</au><au>Corsini, Elena</au><au>Cova, Lidia</au><au>Sala, Simona</au><au>Colombo, Augusto</au><au>Alessandri, Giulio</au><au>Pagano, Stefano F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human neural stem cells express extra-neural markers</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2002-01-25</date><risdate>2002</risdate><volume>925</volume><issue>2</issue><spage>213</spage><epage>221</epage><pages>213-221</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. This suggests that neural stem cells have a greater potential than previously thought, which involves the ability to respond to different and so far unconsidered environmental signals and may be responsible for the recently discovered process of stem cell-fate conversion.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>11792370</pmid><doi>10.1016/S0006-8993(01)03291-7</doi><tpages>9</tpages></addata></record> |
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| subjects | Antigens, CD34 - analysis Antigens, CD34 - biosynthesis Antigens, Differentiation - analysis Antigens, Differentiation - biosynthesis Antigens, Differentiation - genetics Biological and medical sciences Cell Differentiation - physiology Cells, Cultured Embryology: invertebrates and vertebrates. Teratology Embryonic development Endothelial receptors Flow Cytometry Fundamental and applied biological sciences. Psychology Hematopoietic receptors Human CNS stem cells Humans Molecular embryology Multipotent precursors Neurons - cytology Neurons - metabolism Platelet Endothelial Cell Adhesion Molecule-1 - analysis Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis Receptor Protein-Tyrosine Kinases - analysis Receptor Protein-Tyrosine Kinases - biosynthesis Receptor Protein-Tyrosine Kinases - genetics Receptor, TIE-2 Receptors, Growth Factor - analysis Receptors, Growth Factor - biosynthesis Receptors, Growth Factor - genetics Receptors, Vascular Endothelial Growth Factor RNA, Messenger - analysis RNA, Messenger - biosynthesis Stem Cells - chemistry Stem Cells - cytology Stem Cells - metabolism |
| title | Human neural stem cells express extra-neural markers |
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