Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum by controlling alternative gene programs

The Crp-Fnr regulators, named after the first two identified members, are DNA-binding proteins which predominantly function as positive transcription factors, though roles of repressors are also important. Among over 1200 proteins with an N-terminally located nucleotide-binding domain similar to the...

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Veröffentlicht in:	FEMS Microbiology Reviews 2003-12, Vol.27 (5), p.559-592
Hauptverfasser:	Körner, Heinz, Sofia, Heidi J, Zumft, Walter G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptability Adenosine monophosphate Allosteric properties ANOXIA Bacteriology BASIC BIOLOGICAL SCIENCES Binding BIOINFORMATICS Biological and medical sciences CAMP CARBON MONOXIDE Clusters Cyclic adenosine monophosphate cyclic adenosine monophosphate (cAMP) receptor protein Cyclic AMP Cyclic AMP Receptor Protein - genetics Cyclic AMP Receptor Protein - metabolism Deoxyribonucleic acid DNA DNA-binding protein ENVIRONMENTAL SCIENCES Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism FLEXIBILITY Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial GENES Gram-Negative Bacteria - genetics Gram-Negative Bacteria - metabolism Gram-Positive Bacteria - genetics Gram-Positive Bacteria - metabolism HELIX-TURN-HELIX Homology Iron-Sulfur Proteins - genetics Iron-Sulfur Proteins - metabolism Ketoglutaric acid Microbiology Miscellaneous NITRIC OXIDE Nucleotides PHYLOGENY Prostheses Prosthetic groups PROTEINS Redox properties REGULATION OF TRANSCRIPTION Regulators Repressors SUPERFAMILY TARGETS TRANSCRIPTION TRANSCRIPTION FACTORS Transcriptional Activation TREES
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