Activation of Leukocytes During the Uteroplacental Passage in Preeclampsia
Endothelial dysfunction and inflammation appear to play a major role in the pathogenesis of preeclampsia. We hypothesize that a chronic inflammation in the decidua and placenta during preeclampsia may lead to a local leukocyte activation in this compartment. Venous blood was sampled simultaneously f...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2002-01, Vol.39 (1), p.155-160 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Mellembakken, Jan Roar Aukrust, Pål Olafsen, Mette Kløvstad Ueland, Thor Hestdal, Kjetil Videm, Vibeke |
| description | Endothelial dysfunction and inflammation appear to play a major role in the pathogenesis of preeclampsia. We hypothesize that a chronic inflammation in the decidua and placenta during preeclampsia may lead to a local leukocyte activation in this compartment. Venous blood was sampled simultaneously from antecubital and uterine veins during cesarean sections in 30 women with preeclampsia, 29 with uncomplicated pregnancies, and from 17 nonpregnant women. The expression of adhesion molecules and complement-related markers on neutrophils and monocytes was analyzed by flow cytometry. In patients with preeclampsia, neutrophil expression of the integrins CD11a, CD11b, and CD11c and of the complement related markers CD35 and CD59 was significantly higher in samples from uterine than from antecubital veins. No differences were found in nonpregnant women. On monocytes the expression of the Sialyl Lewis antigen, the integrins CD11a, CD11c, and CD49d, and the complement-related markers CD46 and CD59 was higher in samples from uterine than from antecubital veins during preeclampsia, but not in uncomplicated pregnancies, whereas in nonpregnant women CD31 was decreased. Our findings suggest activation of neutrophils and monocytes taking place during the uteroplacental passage in preeclamptic, but not in normal pregnancies. Such a local inflammatory response involving enhanced leukocyte/endothelial interaction may contribute to the pathogenesis of this disorder. |
| doi_str_mv | 10.1161/hy0102.100778 |
| format | Article |
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We hypothesize that a chronic inflammation in the decidua and placenta during preeclampsia may lead to a local leukocyte activation in this compartment. Venous blood was sampled simultaneously from antecubital and uterine veins during cesarean sections in 30 women with preeclampsia, 29 with uncomplicated pregnancies, and from 17 nonpregnant women. The expression of adhesion molecules and complement-related markers on neutrophils and monocytes was analyzed by flow cytometry. In patients with preeclampsia, neutrophil expression of the integrins CD11a, CD11b, and CD11c and of the complement related markers CD35 and CD59 was significantly higher in samples from uterine than from antecubital veins. No differences were found in nonpregnant women. On monocytes the expression of the Sialyl Lewis antigen, the integrins CD11a, CD11c, and CD49d, and the complement-related markers CD46 and CD59 was higher in samples from uterine than from antecubital veins during preeclampsia, but not in uncomplicated pregnancies, whereas in nonpregnant women CD31 was decreased. Our findings suggest activation of neutrophils and monocytes taking place during the uteroplacental passage in preeclamptic, but not in normal pregnancies. Such a local inflammatory response involving enhanced leukocyte/endothelial interaction may contribute to the pathogenesis of this disorder.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/hy0102.100778</identifier><identifier>PMID: 11799095</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Adult ; Antigens, CD - biosynthesis ; Antigens, CD - blood ; Biological and medical sciences ; CD55 Antigens - biosynthesis ; CD55 Antigens - blood ; Cell Adhesion Molecules - biosynthesis ; Cell Adhesion Molecules - blood ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. 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We hypothesize that a chronic inflammation in the decidua and placenta during preeclampsia may lead to a local leukocyte activation in this compartment. Venous blood was sampled simultaneously from antecubital and uterine veins during cesarean sections in 30 women with preeclampsia, 29 with uncomplicated pregnancies, and from 17 nonpregnant women. The expression of adhesion molecules and complement-related markers on neutrophils and monocytes was analyzed by flow cytometry. In patients with preeclampsia, neutrophil expression of the integrins CD11a, CD11b, and CD11c and of the complement related markers CD35 and CD59 was significantly higher in samples from uterine than from antecubital veins. No differences were found in nonpregnant women. On monocytes the expression of the Sialyl Lewis antigen, the integrins CD11a, CD11c, and CD49d, and the complement-related markers CD46 and CD59 was higher in samples from uterine than from antecubital veins during preeclampsia, but not in uncomplicated pregnancies, whereas in nonpregnant women CD31 was decreased. Our findings suggest activation of neutrophils and monocytes taking place during the uteroplacental passage in preeclamptic, but not in normal pregnancies. Such a local inflammatory response involving enhanced leukocyte/endothelial interaction may contribute to the pathogenesis of this disorder.</description><subject>Adult</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD - blood</subject><subject>Biological and medical sciences</subject><subject>CD55 Antigens - biosynthesis</subject><subject>CD55 Antigens - blood</subject><subject>Cell Adhesion Molecules - biosynthesis</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Integrin alpha4</subject><subject>L-Selectin - biosynthesis</subject><subject>L-Selectin - blood</subject><subject>Medical sciences</subject><subject>Monocytes - immunology</subject><subject>Monocytes - metabolism</subject><subject>Neutrophil Activation - physiology</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - metabolism</subject><subject>Placenta - blood supply</subject><subject>Placenta - immunology</subject><subject>Placenta - pathology</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - immunology</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Receptor, Anaphylatoxin C5a</subject><subject>Receptors, Complement - biosynthesis</subject><subject>Receptors, Complement - blood</subject><subject>Uterus - blood supply</subject><subject>Uterus - immunology</subject><subject>Uterus - pathology</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0EFrFDEUwPEgit1Wj15lEPQ29b0kM5k5llarsmAPFryFN9mX7rTZmTWZsey3N2UWCgZCLj_eC38h3iGcI9b4eXsABHmOAMY0L8QKK6lLXdXqpVgBtrpsEX-fiNOU7gFQa21eixNE07bQVivx48JN_V-a-nEoRl-seX4Y3WHiVFzNsR_uimnLxe3EcdwHcjxMFIobSonuuOiH4iYyu0C7ferpjXjlKSR-e3zPxO3XL78uv5Xrn9ffLy_WpauUwdJT49uqAs-ddLLDriEFrnUKCF3la-U96abZ6I3BjSbmWtauNbLVnZLMpM7Ep2XuPo5_Zk6T3fXJcQg08Dgna1BD3UiT4Yf_4P04xyH_zUqoMkApMyoX5OKYUmRv97HfUTxYBPtU2C6F7VI4-_fHoXO3482zPibN4OMRUHIUfKTB9enZKV1po54W68U9jiH3TQ9hfuRot0xh2lrIR8u6KSWAzPsBynwVqn-wA5Ks</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Mellembakken, Jan Roar</creator><creator>Aukrust, Pål</creator><creator>Olafsen, Mette Kløvstad</creator><creator>Ueland, Thor</creator><creator>Hestdal, Kjetil</creator><creator>Videm, Vibeke</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Activation of Leukocytes During the Uteroplacental Passage in Preeclampsia</title><author>Mellembakken, Jan Roar ; Aukrust, Pål ; Olafsen, Mette Kløvstad ; Ueland, Thor ; Hestdal, Kjetil ; Videm, Vibeke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5371-fa8f9550feb2c2b1b8a30c9c30a1c5f63ffa488d4d71d4aee626c97294b32eea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD - blood</topic><topic>Biological and medical sciences</topic><topic>CD55 Antigens - biosynthesis</topic><topic>CD55 Antigens - blood</topic><topic>Cell Adhesion Molecules - biosynthesis</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Integrin alpha4</topic><topic>L-Selectin - biosynthesis</topic><topic>L-Selectin - blood</topic><topic>Medical sciences</topic><topic>Monocytes - immunology</topic><topic>Monocytes - metabolism</topic><topic>Neutrophil Activation - physiology</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - metabolism</topic><topic>Placenta - blood supply</topic><topic>Placenta - immunology</topic><topic>Placenta - pathology</topic><topic>Pre-Eclampsia - blood</topic><topic>Pre-Eclampsia - immunology</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Receptor, Anaphylatoxin C5a</topic><topic>Receptors, Complement - biosynthesis</topic><topic>Receptors, Complement - blood</topic><topic>Uterus - blood supply</topic><topic>Uterus - immunology</topic><topic>Uterus - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mellembakken, Jan Roar</creatorcontrib><creatorcontrib>Aukrust, Pål</creatorcontrib><creatorcontrib>Olafsen, Mette Kløvstad</creatorcontrib><creatorcontrib>Ueland, Thor</creatorcontrib><creatorcontrib>Hestdal, Kjetil</creatorcontrib><creatorcontrib>Videm, Vibeke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mellembakken, Jan Roar</au><au>Aukrust, Pål</au><au>Olafsen, Mette Kløvstad</au><au>Ueland, Thor</au><au>Hestdal, Kjetil</au><au>Videm, Vibeke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of Leukocytes During the Uteroplacental Passage in Preeclampsia</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2002-01</date><risdate>2002</risdate><volume>39</volume><issue>1</issue><spage>155</spage><epage>160</epage><pages>155-160</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Endothelial dysfunction and inflammation appear to play a major role in the pathogenesis of preeclampsia. 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| ispartof | Hypertension (Dallas, Tex. 1979), 2002-01, Vol.39 (1), p.155-160 |
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| subjects | Adult Antigens, CD - biosynthesis Antigens, CD - blood Biological and medical sciences CD55 Antigens - biosynthesis CD55 Antigens - blood Cell Adhesion Molecules - biosynthesis Cell Adhesion Molecules - blood Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Integrin alpha4 L-Selectin - biosynthesis L-Selectin - blood Medical sciences Monocytes - immunology Monocytes - metabolism Neutrophil Activation - physiology Neutrophils - immunology Neutrophils - metabolism Placenta - blood supply Placenta - immunology Placenta - pathology Pre-Eclampsia - blood Pre-Eclampsia - immunology Pregnancy Pregnancy. Fetus. Placenta Receptor, Anaphylatoxin C5a Receptors, Complement - biosynthesis Receptors, Complement - blood Uterus - blood supply Uterus - immunology Uterus - pathology |
| title | Activation of Leukocytes During the Uteroplacental Passage in Preeclampsia |
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