Correlation of Tissue Inhibitor of Metalloproteinase-2 with Proliferative Activity and Patients' Survival in Breast Cancer

Tissue inhibitors of metalloproteinases (TIMPs) are endogenous regulators of matrix metalloproteinases (MMPs). They are believed to possess several distinct cellular functions, particularly the contradictory activities of inhibiting MMPs and promoting tumor cell growth. Immunohistochemistry was perf...

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Veröffentlicht in:	Modern pathology 2002-01, Vol.15 (1), p.26-34
Hauptverfasser:	Nakopoulou, Lydia, Katsarou, Sophia, Giannopoulou, Ioanna, Alexandrou, Paraskevi, Tsirmpa, Ioanna, Panayotopoulou, Effie, Mavrommatis, Johnny, Keramopoulos, Antonios
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinoma, Intraductal, Noninfiltrating - chemistry Carcinoma, Intraductal, Noninfiltrating - mortality Carcinoma, Intraductal, Noninfiltrating - secondary Carcinoma, Lobular - chemistry Carcinoma, Lobular - mortality Carcinoma, Lobular - secondary Cell growth Cell Nucleus Female Fibroblasts Growth factors Humans Immunohistochemistry Laboratory Medicine Lymph Nodes - pathology Lymphatic Metastasis - pathology Medicine Medicine & Public Health Metastasis Middle Aged Neoplasm Proteins - analysis original-article Pathology Proportional Hazards Models Protein expression Proteins Stromal Cells - chemistry Stromal Cells - pathology Survival Survival Rate TIMP-2 Tissue Inhibitor of Metalloproteinase-2 - analysis Tumor growth
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