Marked Increase in Number of Dendritic Cells in Autoimmune‐Prone (NZW × BXSB)F1 Mice with Age
Here, we report that the number of CD11c+CD3− B220− cells increases in autoimmune‐prone male (NZW × BXSB)F1 (W/BF1) mice with age. The CD11c+CD3−B220− cells from W/BF1 mice show a typical stellate shape and induce the proliferation of T cells. In the CD11c+CD3−B220− cells from W/BF1 mice, CD11b (Mac...
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| Veröffentlicht in: | Stem cells (Dayton, Ohio) Ohio), 2002-01, Vol.20 (1), p.61-72 |
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| creator | Adachi, Yashusi Taketani, Shigeru Toki, Junko Ikebukuro, Kazuya Sugiura, Kikuya Oyaizu, Haruki Yasumizu, Ryoji Tomita, Minoru Kaneda, Hiroyuki Amoh, Yasuo Ito, Tomoki Okigaki, Mitsuhiko Inaba, Muneo Ikehara, Susumu |
| description | Here, we report that the number of CD11c+CD3− B220− cells increases in autoimmune‐prone male (NZW × BXSB)F1 (W/BF1) mice with age. The CD11c+CD3−B220− cells from W/BF1 mice show a typical stellate shape and induce the proliferation of T cells. In the CD11c+CD3−B220− cells from W/BF1 mice, CD11b (Mac‐1α), NK 1.1, and CD95 (Fas) are upregulated in comparison with normal mice, while the expression of CD8α, CD117 (c‐kit), CD135 (Flk‐2/Flt‐3), and Sca‐1 decreases. There is a significant increase in Flt‐3L (FL) mRNA in the bone marrow of W/BF1 mice with age. Moreover, activated hemopoietic cells express high levels of FL. The injection of CD11c+CD3−B220− cells from old W/BF1 mice to young W/BF1 mice transiently induces autoimmune disease (thrombocytopenia). These results suggest that hyperproduction of FL from activated hemopoietic cells induces a dramatic increase in the number of dendritic cells in aged W/BF1 mice, followed by the acceleration of autoimmunity. |
| doi_str_mv | 10.1634/stemcells.20-1-61 |
| format | Article |
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The CD11c+CD3−B220− cells from W/BF1 mice show a typical stellate shape and induce the proliferation of T cells. In the CD11c+CD3−B220− cells from W/BF1 mice, CD11b (Mac‐1α), NK 1.1, and CD95 (Fas) are upregulated in comparison with normal mice, while the expression of CD8α, CD117 (c‐kit), CD135 (Flk‐2/Flt‐3), and Sca‐1 decreases. There is a significant increase in Flt‐3L (FL) mRNA in the bone marrow of W/BF1 mice with age. Moreover, activated hemopoietic cells express high levels of FL. The injection of CD11c+CD3−B220− cells from old W/BF1 mice to young W/BF1 mice transiently induces autoimmune disease (thrombocytopenia). These results suggest that hyperproduction of FL from activated hemopoietic cells induces a dramatic increase in the number of dendritic cells in aged W/BF1 mice, followed by the acceleration of autoimmunity.</description><identifier>ISSN: 1066-5099</identifier><identifier>EISSN: 1549-4918</identifier><identifier>DOI: 10.1634/stemcells.20-1-61</identifier><identifier>PMID: 11796923</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>(NZW × BXSB)F1 mouse ; Animals ; Autoimmune disease ; Bone Marrow - metabolism ; CD11 Antigens - biosynthesis ; CD4-Positive T-Lymphocytes - metabolism ; CD8 Antigens - biosynthesis ; Cell Division ; Cell Line ; Cell Membrane - metabolism ; Crosses, Genetic ; Dendritic cell ; Dendritic Cells - cytology ; Dendritic Cells - metabolism ; Endocytosis ; fas Receptor - biosynthesis ; Flow Cytometry ; Flt‐3 ligand ; fms-Like Tyrosine Kinase 3 ; Integrin alphaXbeta2 - biosynthesis ; Leukocytes, Mononuclear - metabolism ; Lymphocytes - metabolism ; Membrane Proteins - biosynthesis ; Mice ; Phagocytosis ; Proto-Oncogene Proteins - biosynthesis ; Proto-Oncogene Proteins c-kit - biosynthesis ; Receptor Protein-Tyrosine Kinases - biosynthesis ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Thrombocytopenia - metabolism ; Time Factors ; Up-Regulation</subject><ispartof>Stem cells (Dayton, Ohio), 2002-01, Vol.20 (1), p.61-72</ispartof><rights>Copyright © 2002 AlphaMed Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3901-77592f4199abd9c24ba0ffb3cf32a830f794008221670768d4214874104099903</citedby><cites>FETCH-LOGICAL-c3901-77592f4199abd9c24ba0ffb3cf32a830f794008221670768d4214874104099903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11796923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adachi, Yashusi</creatorcontrib><creatorcontrib>Taketani, Shigeru</creatorcontrib><creatorcontrib>Toki, Junko</creatorcontrib><creatorcontrib>Ikebukuro, Kazuya</creatorcontrib><creatorcontrib>Sugiura, Kikuya</creatorcontrib><creatorcontrib>Oyaizu, Haruki</creatorcontrib><creatorcontrib>Yasumizu, Ryoji</creatorcontrib><creatorcontrib>Tomita, Minoru</creatorcontrib><creatorcontrib>Kaneda, Hiroyuki</creatorcontrib><creatorcontrib>Amoh, Yasuo</creatorcontrib><creatorcontrib>Ito, Tomoki</creatorcontrib><creatorcontrib>Okigaki, Mitsuhiko</creatorcontrib><creatorcontrib>Inaba, Muneo</creatorcontrib><creatorcontrib>Ikehara, Susumu</creatorcontrib><title>Marked Increase in Number of Dendritic Cells in Autoimmune‐Prone (NZW × BXSB)F1 Mice with Age</title><title>Stem cells (Dayton, Ohio)</title><addtitle>Stem Cells</addtitle><description>Here, we report that the number of CD11c+CD3− B220− cells increases in autoimmune‐prone male (NZW × BXSB)F1 (W/BF1) mice with age. The CD11c+CD3−B220− cells from W/BF1 mice show a typical stellate shape and induce the proliferation of T cells. In the CD11c+CD3−B220− cells from W/BF1 mice, CD11b (Mac‐1α), NK 1.1, and CD95 (Fas) are upregulated in comparison with normal mice, while the expression of CD8α, CD117 (c‐kit), CD135 (Flk‐2/Flt‐3), and Sca‐1 decreases. There is a significant increase in Flt‐3L (FL) mRNA in the bone marrow of W/BF1 mice with age. Moreover, activated hemopoietic cells express high levels of FL. The injection of CD11c+CD3−B220− cells from old W/BF1 mice to young W/BF1 mice transiently induces autoimmune disease (thrombocytopenia). These results suggest that hyperproduction of FL from activated hemopoietic cells induces a dramatic increase in the number of dendritic cells in aged W/BF1 mice, followed by the acceleration of autoimmunity.</description><subject>(NZW × BXSB)F1 mouse</subject><subject>Animals</subject><subject>Autoimmune disease</subject><subject>Bone Marrow - metabolism</subject><subject>CD11 Antigens - biosynthesis</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>CD8 Antigens - biosynthesis</subject><subject>Cell Division</subject><subject>Cell Line</subject><subject>Cell Membrane - metabolism</subject><subject>Crosses, Genetic</subject><subject>Dendritic cell</subject><subject>Dendritic Cells - cytology</subject><subject>Dendritic Cells - metabolism</subject><subject>Endocytosis</subject><subject>fas Receptor - biosynthesis</subject><subject>Flow Cytometry</subject><subject>Flt‐3 ligand</subject><subject>fms-Like Tyrosine Kinase 3</subject><subject>Integrin alphaXbeta2 - biosynthesis</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Lymphocytes - metabolism</subject><subject>Membrane Proteins - biosynthesis</subject><subject>Mice</subject><subject>Phagocytosis</subject><subject>Proto-Oncogene Proteins - biosynthesis</subject><subject>Proto-Oncogene Proteins c-kit - biosynthesis</subject><subject>Receptor Protein-Tyrosine Kinases - biosynthesis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Thrombocytopenia - metabolism</subject><subject>Time Factors</subject><subject>Up-Regulation</subject><issn>1066-5099</issn><issn>1549-4918</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtOw0AMhkcIxKNwADZoVggWKfZkmmSWpbSARAEJEIjNkIcDA00CM4kQO47AjgNxE05CqlawxBtb9u_f8sfYJkIXA1_uuZqKlCYT1xXgoRfgAlvFnlSeVBgttjUEgdcDpVbYmnOPACh7UbTMVhBDFSjhr7K7cWyfKOPHZWopdsRNyU-bIiHLq5wfUJlZU5uUD6ZnpsN-U1emKJqSvt8_zm1VEt85vb3mX598_-Zif3eEfGxS4q-mfuD9e1pnS3k8cbQxzx12NRpeDo68k7PD40H_xEt9BeiFYU-JXKJScZKpVMgkhjxP_DT3RRz5kIdKAkRCYBBCGESZFCijUCLI9j8Ffodtz3yfbfXSkKt1YdwUTlxS1TgdogTZRivEmTC1lXOWcv1sTRHbN42gp1j1L1Yt2o4OsN3Zmps3SUHZ38acYytQM8GrmdDb_4764nI4FgDQmv8Amz-GdA</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Adachi, Yashusi</creator><creator>Taketani, Shigeru</creator><creator>Toki, Junko</creator><creator>Ikebukuro, Kazuya</creator><creator>Sugiura, Kikuya</creator><creator>Oyaizu, Haruki</creator><creator>Yasumizu, Ryoji</creator><creator>Tomita, Minoru</creator><creator>Kaneda, Hiroyuki</creator><creator>Amoh, Yasuo</creator><creator>Ito, Tomoki</creator><creator>Okigaki, Mitsuhiko</creator><creator>Inaba, Muneo</creator><creator>Ikehara, Susumu</creator><general>John Wiley & Sons, Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Marked Increase in Number of Dendritic Cells in Autoimmune‐Prone (NZW × BXSB)F1 Mice with Age</title><author>Adachi, Yashusi ; Taketani, Shigeru ; Toki, Junko ; Ikebukuro, Kazuya ; Sugiura, Kikuya ; Oyaizu, Haruki ; Yasumizu, Ryoji ; Tomita, Minoru ; Kaneda, Hiroyuki ; Amoh, Yasuo ; Ito, Tomoki ; Okigaki, Mitsuhiko ; Inaba, Muneo ; Ikehara, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3901-77592f4199abd9c24ba0ffb3cf32a830f794008221670768d4214874104099903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>(NZW × BXSB)F1 mouse</topic><topic>Animals</topic><topic>Autoimmune disease</topic><topic>Bone Marrow - metabolism</topic><topic>CD11 Antigens - biosynthesis</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>CD8 Antigens - biosynthesis</topic><topic>Cell Division</topic><topic>Cell Line</topic><topic>Cell Membrane - metabolism</topic><topic>Crosses, Genetic</topic><topic>Dendritic cell</topic><topic>Dendritic Cells - cytology</topic><topic>Dendritic Cells - metabolism</topic><topic>Endocytosis</topic><topic>fas Receptor - biosynthesis</topic><topic>Flow Cytometry</topic><topic>Flt‐3 ligand</topic><topic>fms-Like Tyrosine Kinase 3</topic><topic>Integrin alphaXbeta2 - biosynthesis</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Lymphocytes - metabolism</topic><topic>Membrane Proteins - biosynthesis</topic><topic>Mice</topic><topic>Phagocytosis</topic><topic>Proto-Oncogene Proteins - biosynthesis</topic><topic>Proto-Oncogene Proteins c-kit - biosynthesis</topic><topic>Receptor Protein-Tyrosine Kinases - biosynthesis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - metabolism</topic><topic>Thrombocytopenia - metabolism</topic><topic>Time Factors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adachi, Yashusi</creatorcontrib><creatorcontrib>Taketani, Shigeru</creatorcontrib><creatorcontrib>Toki, Junko</creatorcontrib><creatorcontrib>Ikebukuro, Kazuya</creatorcontrib><creatorcontrib>Sugiura, Kikuya</creatorcontrib><creatorcontrib>Oyaizu, Haruki</creatorcontrib><creatorcontrib>Yasumizu, Ryoji</creatorcontrib><creatorcontrib>Tomita, Minoru</creatorcontrib><creatorcontrib>Kaneda, Hiroyuki</creatorcontrib><creatorcontrib>Amoh, Yasuo</creatorcontrib><creatorcontrib>Ito, Tomoki</creatorcontrib><creatorcontrib>Okigaki, Mitsuhiko</creatorcontrib><creatorcontrib>Inaba, Muneo</creatorcontrib><creatorcontrib>Ikehara, Susumu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stem cells (Dayton, Ohio)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adachi, Yashusi</au><au>Taketani, Shigeru</au><au>Toki, Junko</au><au>Ikebukuro, Kazuya</au><au>Sugiura, Kikuya</au><au>Oyaizu, Haruki</au><au>Yasumizu, Ryoji</au><au>Tomita, Minoru</au><au>Kaneda, Hiroyuki</au><au>Amoh, Yasuo</au><au>Ito, Tomoki</au><au>Okigaki, Mitsuhiko</au><au>Inaba, Muneo</au><au>Ikehara, Susumu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Marked Increase in Number of Dendritic Cells in Autoimmune‐Prone (NZW × BXSB)F1 Mice with Age</atitle><jtitle>Stem cells (Dayton, Ohio)</jtitle><addtitle>Stem Cells</addtitle><date>2002-01</date><risdate>2002</risdate><volume>20</volume><issue>1</issue><spage>61</spage><epage>72</epage><pages>61-72</pages><issn>1066-5099</issn><eissn>1549-4918</eissn><abstract>Here, we report that the number of CD11c+CD3− B220− cells increases in autoimmune‐prone male (NZW × BXSB)F1 (W/BF1) mice with age. The CD11c+CD3−B220− cells from W/BF1 mice show a typical stellate shape and induce the proliferation of T cells. In the CD11c+CD3−B220− cells from W/BF1 mice, CD11b (Mac‐1α), NK 1.1, and CD95 (Fas) are upregulated in comparison with normal mice, while the expression of CD8α, CD117 (c‐kit), CD135 (Flk‐2/Flt‐3), and Sca‐1 decreases. There is a significant increase in Flt‐3L (FL) mRNA in the bone marrow of W/BF1 mice with age. Moreover, activated hemopoietic cells express high levels of FL. The injection of CD11c+CD3−B220− cells from old W/BF1 mice to young W/BF1 mice transiently induces autoimmune disease (thrombocytopenia). These results suggest that hyperproduction of FL from activated hemopoietic cells induces a dramatic increase in the number of dendritic cells in aged W/BF1 mice, followed by the acceleration of autoimmunity.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>11796923</pmid><doi>10.1634/stemcells.20-1-61</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | (NZW × BXSB)F1 mouse Animals Autoimmune disease Bone Marrow - metabolism CD11 Antigens - biosynthesis CD4-Positive T-Lymphocytes - metabolism CD8 Antigens - biosynthesis Cell Division Cell Line Cell Membrane - metabolism Crosses, Genetic Dendritic cell Dendritic Cells - cytology Dendritic Cells - metabolism Endocytosis fas Receptor - biosynthesis Flow Cytometry Flt‐3 ligand fms-Like Tyrosine Kinase 3 Integrin alphaXbeta2 - biosynthesis Leukocytes, Mononuclear - metabolism Lymphocytes - metabolism Membrane Proteins - biosynthesis Mice Phagocytosis Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins c-kit - biosynthesis Receptor Protein-Tyrosine Kinases - biosynthesis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Thrombocytopenia - metabolism Time Factors Up-Regulation |
| title | Marked Increase in Number of Dendritic Cells in Autoimmune‐Prone (NZW × BXSB)F1 Mice with Age |
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