Ion channel gating: insights via molecular simulations

Ion channels are gated, i.e. they can switch conformation between a closed and an open state. Molecular dynamics simulations may be used to study the conformational dynamics of ion channels and of simple channel models. Simulations on model nanopores reveal that a narrow (

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Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 2003-11, Vol.555 (1), p.85-90
Hauptverfasser:	Beckstein, Oliver, Biggin, Philip C, Bond, Peter, Bright, Joanne N, Domene, Carmen, Grottesi, Alessandro, Holyoake, John, Sansom, Mark S.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - metabolism Gating Hydrophobic and Hydrophilic Interactions Ion channel Ion Channel Gating Ion Channels - chemistry Ion Channels - metabolism Models, Molecular Molecolar dynamics Nanopore Outer membrane protein Pore Potassium Channels - chemistry Potassium Channels - metabolism Protein Conformation Thermodynamics
Online-Zugang:	Volltext
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