Relationship between the Pfcrt T76 and the Pfmdr-1 Y86 mutations in Plasmodium falciparum and in vitro/in vivo chloroquine resistance in Burkina Faso, West Africa

The relationship between Pfcrt T76 and Pfmdr-1 Y86 mutations in Plasmodium falciparum was explored in samples from patients with uncomplicated malaria and tested in vitro and in vivo with chloroquine (CQ) in Burkina Faso. The two mutations were strongly related. The Pfcrt T76 mutation was found in 8...

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Veröffentlicht in:	Infection, genetics and evolution genetics and evolution, 2003-11, Vol.3 (4), p.287-292
Hauptverfasser:	Tinto, Halidou, Ouédraogo, Jean Bosco, Erhart, Annette, Van Overmeir, Chantal, Dujardin, Jean-Claude, Van Marck, Eric, Guiguemdé, Tinga Robert, D’Alessandro, Umberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animals Antimalarials - pharmacology Burkina Faso Child Child, Preschool Chloroquine - pharmacology Chloroquine resistance Drug Resistance, Microbial - genetics Genetics, Population Humans Infant Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Membrane Proteins - drug effects Membrane Proteins - genetics Membrane Transport Proteins Microbial Sensitivity Tests Mutation Pfcrt Pfmdr-1 Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Protozoan Proteins Treatment Outcome
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