Short-term glucocorticoid treatment of piglets causes changes in growth plate morphology and angiogenesis

Objective: Glucocorticoid treatment of children often leads to growth retardation, and the precise target(s) in the growth plate responsible for this effect are unknown. Angiogenesis is an important part of the endochondral ossification process, and VEGF expressed in the growth plate is essential fo...

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Veröffentlicht in:	Osteoarthritis and cartilage 2003-12, Vol.11 (12), p.864-871
Hauptverfasser:	Smink, J.J, Buchholz, I.M, Hamers, N, van Tilburg, C.M, Christis, C, Sakkers, R.J.B, de Meer, K, van Buul-Offers, S.C, Koedam, J.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis - drug effects Capillaries Female Glucocorticoid Glucocorticoids - pharmacology Growth plate Growth Plate - anatomy & histology Growth Plate - drug effects Growth Plate - metabolism Immunohistochemistry - methods In Situ Hybridization - methods In Situ Nick-End Labeling - methods Matrix Metalloproteinase 9 - analysis Neovascularization, Physiologic - drug effects Porcine Prednisolone - pharmacology RNA, Messenger - analysis Swine Tibia Vascular Endothelial Growth Factor A - analysis VEGF
Online-Zugang:	Volltext
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