Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study

OBJECTIVETo investigate whether the administration of transdermal estradiol is capable of modifying circulating levels of leptin. DESIGNForty postmenopausal women randomly received in a double-blind fashion, a transdermal patch containing either placebo or estradiol (50 μg/day). After 2 months of tr...

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Veröffentlicht in:Menopause (New York, N.Y.) N.Y.), 2002-01, Vol.9 (1), p.65-71
Hauptverfasser: Cagnacci, Angelo, Malmusi, Stefania, Arangino, Serenella, Zanni, Annalisa, Rovati, Lucio, Cagnacci, Paolo, Volpe, Annibale
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container_end_page 71
container_issue 1
container_start_page 65
container_title Menopause (New York, N.Y.)
container_volume 9
creator Cagnacci, Angelo
Malmusi, Stefania
Arangino, Serenella
Zanni, Annalisa
Rovati, Lucio
Cagnacci, Paolo
Volpe, Annibale
description OBJECTIVETo investigate whether the administration of transdermal estradiol is capable of modifying circulating levels of leptin. DESIGNForty postmenopausal women randomly received in a double-blind fashion, a transdermal patch containing either placebo or estradiol (50 μg/day). After 2 months of treatment, they were switched to the alternate treatment for another 2 months. Leptin levels were measured at the end of the placebo and estradiol administration. In a subset of 28 women an evaluation of body composition via bioelectrical impedance and an oral glucose tolerance test (OGTT; 75 g) were also performed at the end of the placebo and estradiol administration. Glucose, insulin, and leptin levels were measured in all OGTT samples. RESULTSLeptin levels were related directly to body mass index (BMI), fat mass, and insulin, and inversely related to lean mass. In comparison to placebo, transdermal estradiol increased estradiol (from 77.8 ± 8.4 pmol/l to 183.1 ± 20.9 pmol/l;p < 0.0001) but did not significantly modify leptin (19.1 ± 2.4 μg/l vs. 18.6 ± 2 μg/l) or BMI. Estradiol did not modify fat mass or lean mass, significantly increased intracellular water (31.1 ± 0.7% vs. 37.2 ± 2.3%, p < 0.05), and decreased extracellular water (40.5 ± 0.7% vs. 36.3 ± 1.7%;p < 0.04). Leptin did not increase during OGTT, but a significant decrease, linearly related to BMI (r = 0.519;p = 0.0189), was observed at the end of the test. CONCLUSIONSLow doses of transdermal estradiol exert no influence on fasting leptin levels or BMI. The possibility that different doses of estradiol exert a more pronounced effect on circulating leptin needs to be addressed in comparative studies.
doi_str_mv 10.1097/00042192-200201000-00010
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DESIGNForty postmenopausal women randomly received in a double-blind fashion, a transdermal patch containing either placebo or estradiol (50 μg/day). After 2 months of treatment, they were switched to the alternate treatment for another 2 months. Leptin levels were measured at the end of the placebo and estradiol administration. In a subset of 28 women an evaluation of body composition via bioelectrical impedance and an oral glucose tolerance test (OGTT; 75 g) were also performed at the end of the placebo and estradiol administration. Glucose, insulin, and leptin levels were measured in all OGTT samples. RESULTSLeptin levels were related directly to body mass index (BMI), fat mass, and insulin, and inversely related to lean mass. In comparison to placebo, transdermal estradiol increased estradiol (from 77.8 ± 8.4 pmol/l to 183.1 ± 20.9 pmol/l;p &lt; 0.0001) but did not significantly modify leptin (19.1 ± 2.4 μg/l vs. 18.6 ± 2 μg/l) or BMI. Estradiol did not modify fat mass or lean mass, significantly increased intracellular water (31.1 ± 0.7% vs. 37.2 ± 2.3%, p &lt; 0.05), and decreased extracellular water (40.5 ± 0.7% vs. 36.3 ± 1.7%;p &lt; 0.04). Leptin did not increase during OGTT, but a significant decrease, linearly related to BMI (r = 0.519;p = 0.0189), was observed at the end of the test. CONCLUSIONSLow doses of transdermal estradiol exert no influence on fasting leptin levels or BMI. The possibility that different doses of estradiol exert a more pronounced effect on circulating leptin needs to be addressed in comparative studies.</description><identifier>ISSN: 1072-3714</identifier><identifier>EISSN: 1530-0374</identifier><identifier>DOI: 10.1097/00042192-200201000-00010</identifier><identifier>PMID: 11791088</identifier><language>eng</language><publisher>United States: The North American Menopause Society</publisher><subject>Administration, Cutaneous ; Body Composition ; Body Water - drug effects ; Cross-Over Studies ; Double-Blind Method ; Estradiol - administration &amp; dosage ; Fasting - blood ; Female ; Glucose Tolerance Test ; Humans ; Insulin - blood ; Leptin - blood ; Middle Aged ; Postmenopause - drug effects ; Postmenopause - metabolism</subject><ispartof>Menopause (New York, N.Y.), 2002-01, Vol.9 (1), p.65-71</ispartof><rights>2002The North American Menopause Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3560-305e10300e98a2879293390a7e5cdf7ec099319a914394b9df5132a87ce442243</citedby><cites>FETCH-LOGICAL-c3560-305e10300e98a2879293390a7e5cdf7ec099319a914394b9df5132a87ce442243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11791088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cagnacci, Angelo</creatorcontrib><creatorcontrib>Malmusi, Stefania</creatorcontrib><creatorcontrib>Arangino, Serenella</creatorcontrib><creatorcontrib>Zanni, Annalisa</creatorcontrib><creatorcontrib>Rovati, Lucio</creatorcontrib><creatorcontrib>Cagnacci, Paolo</creatorcontrib><creatorcontrib>Volpe, Annibale</creatorcontrib><title>Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study</title><title>Menopause (New York, N.Y.)</title><addtitle>Menopause</addtitle><description>OBJECTIVETo investigate whether the administration of transdermal estradiol is capable of modifying circulating levels of leptin. DESIGNForty postmenopausal women randomly received in a double-blind fashion, a transdermal patch containing either placebo or estradiol (50 μg/day). After 2 months of treatment, they were switched to the alternate treatment for another 2 months. Leptin levels were measured at the end of the placebo and estradiol administration. In a subset of 28 women an evaluation of body composition via bioelectrical impedance and an oral glucose tolerance test (OGTT; 75 g) were also performed at the end of the placebo and estradiol administration. Glucose, insulin, and leptin levels were measured in all OGTT samples. RESULTSLeptin levels were related directly to body mass index (BMI), fat mass, and insulin, and inversely related to lean mass. In comparison to placebo, transdermal estradiol increased estradiol (from 77.8 ± 8.4 pmol/l to 183.1 ± 20.9 pmol/l;p &lt; 0.0001) but did not significantly modify leptin (19.1 ± 2.4 μg/l vs. 18.6 ± 2 μg/l) or BMI. Estradiol did not modify fat mass or lean mass, significantly increased intracellular water (31.1 ± 0.7% vs. 37.2 ± 2.3%, p &lt; 0.05), and decreased extracellular water (40.5 ± 0.7% vs. 36.3 ± 1.7%;p &lt; 0.04). Leptin did not increase during OGTT, but a significant decrease, linearly related to BMI (r = 0.519;p = 0.0189), was observed at the end of the test. CONCLUSIONSLow doses of transdermal estradiol exert no influence on fasting leptin levels or BMI. The possibility that different doses of estradiol exert a more pronounced effect on circulating leptin needs to be addressed in comparative studies.</description><subject>Administration, Cutaneous</subject><subject>Body Composition</subject><subject>Body Water - drug effects</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Estradiol - administration &amp; dosage</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Leptin - blood</subject><subject>Middle Aged</subject><subject>Postmenopause - drug effects</subject><subject>Postmenopause - metabolism</subject><issn>1072-3714</issn><issn>1530-0374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctuFDEQRS1ERELgF5BXrGgoPxq32aGIR6RIbJK15barmQZ3u_GDUb4gv42HGWDFwrKv69yyXJcQyuA1A63eAIDkTPOOA3BgTXZtMXhELlgvmhBKPm5nULwTislz8jTnbw3hmqsn5JwxpRkMwwV5uF6nUHF1SONES7Jr9pgWGyjmpvwcA51XWnZIE36twZY5rgc04FZaIeBPDPlwscVcFlzjZmtu9n1s4h211Mc6BuzGMK_-Fd2CdTjGzsW1pBgCeppL9ffPyNlkQ8bnp_2S3H38cHv1ubv58un66v1N50T_FjoBPTIQAKgHyweluRZCg1XYOz8pdKC1YNpqJoWWo_ZTzwS3g3IoJedSXJKXx75bij9q-6NZ5uwwBLtirNkoJrTWIBo4HEGXYs4JJ7OlebHp3jAwhxDMnxDM3xDM7xCa9cXpjTou6P8ZT1NvgDwC-xgKpvw91D0ms0Mbys78L1zxC4Bmksg</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Cagnacci, Angelo</creator><creator>Malmusi, Stefania</creator><creator>Arangino, Serenella</creator><creator>Zanni, Annalisa</creator><creator>Rovati, Lucio</creator><creator>Cagnacci, Paolo</creator><creator>Volpe, Annibale</creator><general>The North American Menopause Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study</title><author>Cagnacci, Angelo ; Malmusi, Stefania ; Arangino, Serenella ; Zanni, Annalisa ; Rovati, Lucio ; Cagnacci, Paolo ; Volpe, Annibale</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3560-305e10300e98a2879293390a7e5cdf7ec099319a914394b9df5132a87ce442243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Cutaneous</topic><topic>Body Composition</topic><topic>Body Water - drug effects</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Estradiol - administration &amp; dosage</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Leptin - blood</topic><topic>Middle Aged</topic><topic>Postmenopause - drug effects</topic><topic>Postmenopause - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cagnacci, Angelo</creatorcontrib><creatorcontrib>Malmusi, Stefania</creatorcontrib><creatorcontrib>Arangino, Serenella</creatorcontrib><creatorcontrib>Zanni, Annalisa</creatorcontrib><creatorcontrib>Rovati, Lucio</creatorcontrib><creatorcontrib>Cagnacci, Paolo</creatorcontrib><creatorcontrib>Volpe, Annibale</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Menopause (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cagnacci, Angelo</au><au>Malmusi, Stefania</au><au>Arangino, Serenella</au><au>Zanni, Annalisa</au><au>Rovati, Lucio</au><au>Cagnacci, Paolo</au><au>Volpe, Annibale</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study</atitle><jtitle>Menopause (New York, N.Y.)</jtitle><addtitle>Menopause</addtitle><date>2002-01</date><risdate>2002</risdate><volume>9</volume><issue>1</issue><spage>65</spage><epage>71</epage><pages>65-71</pages><issn>1072-3714</issn><eissn>1530-0374</eissn><abstract>OBJECTIVETo investigate whether the administration of transdermal estradiol is capable of modifying circulating levels of leptin. DESIGNForty postmenopausal women randomly received in a double-blind fashion, a transdermal patch containing either placebo or estradiol (50 μg/day). After 2 months of treatment, they were switched to the alternate treatment for another 2 months. Leptin levels were measured at the end of the placebo and estradiol administration. In a subset of 28 women an evaluation of body composition via bioelectrical impedance and an oral glucose tolerance test (OGTT; 75 g) were also performed at the end of the placebo and estradiol administration. Glucose, insulin, and leptin levels were measured in all OGTT samples. RESULTSLeptin levels were related directly to body mass index (BMI), fat mass, and insulin, and inversely related to lean mass. In comparison to placebo, transdermal estradiol increased estradiol (from 77.8 ± 8.4 pmol/l to 183.1 ± 20.9 pmol/l;p &lt; 0.0001) but did not significantly modify leptin (19.1 ± 2.4 μg/l vs. 18.6 ± 2 μg/l) or BMI. Estradiol did not modify fat mass or lean mass, significantly increased intracellular water (31.1 ± 0.7% vs. 37.2 ± 2.3%, p &lt; 0.05), and decreased extracellular water (40.5 ± 0.7% vs. 36.3 ± 1.7%;p &lt; 0.04). Leptin did not increase during OGTT, but a significant decrease, linearly related to BMI (r = 0.519;p = 0.0189), was observed at the end of the test. CONCLUSIONSLow doses of transdermal estradiol exert no influence on fasting leptin levels or BMI. The possibility that different doses of estradiol exert a more pronounced effect on circulating leptin needs to be addressed in comparative studies.</abstract><cop>United States</cop><pub>The North American Menopause Society</pub><pmid>11791088</pmid><doi>10.1097/00042192-200201000-00010</doi><tpages>7</tpages></addata></record>
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source Journals@Ovid Ovid Autoload; MEDLINE
subjects Administration, Cutaneous
Body Composition
Body Water - drug effects
Cross-Over Studies
Double-Blind Method
Estradiol - administration & dosage
Fasting - blood
Female
Glucose Tolerance Test
Humans
Insulin - blood
Leptin - blood
Middle Aged
Postmenopause - drug effects
Postmenopause - metabolism
title Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study
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