Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study
OBJECTIVETo investigate whether the administration of transdermal estradiol is capable of modifying circulating levels of leptin. DESIGNForty postmenopausal women randomly received in a double-blind fashion, a transdermal patch containing either placebo or estradiol (50 μg/day). After 2 months of tr...
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Veröffentlicht in: | Menopause (New York, N.Y.) N.Y.), 2002-01, Vol.9 (1), p.65-71 |
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creator | Cagnacci, Angelo Malmusi, Stefania Arangino, Serenella Zanni, Annalisa Rovati, Lucio Cagnacci, Paolo Volpe, Annibale |
description | OBJECTIVETo investigate whether the administration of transdermal estradiol is capable of modifying circulating levels of leptin.
DESIGNForty postmenopausal women randomly received in a double-blind fashion, a transdermal patch containing either placebo or estradiol (50 μg/day). After 2 months of treatment, they were switched to the alternate treatment for another 2 months. Leptin levels were measured at the end of the placebo and estradiol administration. In a subset of 28 women an evaluation of body composition via bioelectrical impedance and an oral glucose tolerance test (OGTT; 75 g) were also performed at the end of the placebo and estradiol administration. Glucose, insulin, and leptin levels were measured in all OGTT samples.
RESULTSLeptin levels were related directly to body mass index (BMI), fat mass, and insulin, and inversely related to lean mass. In comparison to placebo, transdermal estradiol increased estradiol (from 77.8 ± 8.4 pmol/l to 183.1 ± 20.9 pmol/l;p < 0.0001) but did not significantly modify leptin (19.1 ± 2.4 μg/l vs. 18.6 ± 2 μg/l) or BMI. Estradiol did not modify fat mass or lean mass, significantly increased intracellular water (31.1 ± 0.7% vs. 37.2 ± 2.3%, p < 0.05), and decreased extracellular water (40.5 ± 0.7% vs. 36.3 ± 1.7%;p < 0.04). Leptin did not increase during OGTT, but a significant decrease, linearly related to BMI (r = 0.519;p = 0.0189), was observed at the end of the test.
CONCLUSIONSLow doses of transdermal estradiol exert no influence on fasting leptin levels or BMI. The possibility that different doses of estradiol exert a more pronounced effect on circulating leptin needs to be addressed in comparative studies. |
doi_str_mv | 10.1097/00042192-200201000-00010 |
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DESIGNForty postmenopausal women randomly received in a double-blind fashion, a transdermal patch containing either placebo or estradiol (50 μg/day). After 2 months of treatment, they were switched to the alternate treatment for another 2 months. Leptin levels were measured at the end of the placebo and estradiol administration. In a subset of 28 women an evaluation of body composition via bioelectrical impedance and an oral glucose tolerance test (OGTT; 75 g) were also performed at the end of the placebo and estradiol administration. Glucose, insulin, and leptin levels were measured in all OGTT samples.
RESULTSLeptin levels were related directly to body mass index (BMI), fat mass, and insulin, and inversely related to lean mass. In comparison to placebo, transdermal estradiol increased estradiol (from 77.8 ± 8.4 pmol/l to 183.1 ± 20.9 pmol/l;p < 0.0001) but did not significantly modify leptin (19.1 ± 2.4 μg/l vs. 18.6 ± 2 μg/l) or BMI. Estradiol did not modify fat mass or lean mass, significantly increased intracellular water (31.1 ± 0.7% vs. 37.2 ± 2.3%, p < 0.05), and decreased extracellular water (40.5 ± 0.7% vs. 36.3 ± 1.7%;p < 0.04). Leptin did not increase during OGTT, but a significant decrease, linearly related to BMI (r = 0.519;p = 0.0189), was observed at the end of the test.
CONCLUSIONSLow doses of transdermal estradiol exert no influence on fasting leptin levels or BMI. The possibility that different doses of estradiol exert a more pronounced effect on circulating leptin needs to be addressed in comparative studies.</description><identifier>ISSN: 1072-3714</identifier><identifier>EISSN: 1530-0374</identifier><identifier>DOI: 10.1097/00042192-200201000-00010</identifier><identifier>PMID: 11791088</identifier><language>eng</language><publisher>United States: The North American Menopause Society</publisher><subject>Administration, Cutaneous ; Body Composition ; Body Water - drug effects ; Cross-Over Studies ; Double-Blind Method ; Estradiol - administration & dosage ; Fasting - blood ; Female ; Glucose Tolerance Test ; Humans ; Insulin - blood ; Leptin - blood ; Middle Aged ; Postmenopause - drug effects ; Postmenopause - metabolism</subject><ispartof>Menopause (New York, N.Y.), 2002-01, Vol.9 (1), p.65-71</ispartof><rights>2002The North American Menopause Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3560-305e10300e98a2879293390a7e5cdf7ec099319a914394b9df5132a87ce442243</citedby><cites>FETCH-LOGICAL-c3560-305e10300e98a2879293390a7e5cdf7ec099319a914394b9df5132a87ce442243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11791088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cagnacci, Angelo</creatorcontrib><creatorcontrib>Malmusi, Stefania</creatorcontrib><creatorcontrib>Arangino, Serenella</creatorcontrib><creatorcontrib>Zanni, Annalisa</creatorcontrib><creatorcontrib>Rovati, Lucio</creatorcontrib><creatorcontrib>Cagnacci, Paolo</creatorcontrib><creatorcontrib>Volpe, Annibale</creatorcontrib><title>Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study</title><title>Menopause (New York, N.Y.)</title><addtitle>Menopause</addtitle><description>OBJECTIVETo investigate whether the administration of transdermal estradiol is capable of modifying circulating levels of leptin.
DESIGNForty postmenopausal women randomly received in a double-blind fashion, a transdermal patch containing either placebo or estradiol (50 μg/day). After 2 months of treatment, they were switched to the alternate treatment for another 2 months. Leptin levels were measured at the end of the placebo and estradiol administration. In a subset of 28 women an evaluation of body composition via bioelectrical impedance and an oral glucose tolerance test (OGTT; 75 g) were also performed at the end of the placebo and estradiol administration. Glucose, insulin, and leptin levels were measured in all OGTT samples.
RESULTSLeptin levels were related directly to body mass index (BMI), fat mass, and insulin, and inversely related to lean mass. In comparison to placebo, transdermal estradiol increased estradiol (from 77.8 ± 8.4 pmol/l to 183.1 ± 20.9 pmol/l;p < 0.0001) but did not significantly modify leptin (19.1 ± 2.4 μg/l vs. 18.6 ± 2 μg/l) or BMI. Estradiol did not modify fat mass or lean mass, significantly increased intracellular water (31.1 ± 0.7% vs. 37.2 ± 2.3%, p < 0.05), and decreased extracellular water (40.5 ± 0.7% vs. 36.3 ± 1.7%;p < 0.04). Leptin did not increase during OGTT, but a significant decrease, linearly related to BMI (r = 0.519;p = 0.0189), was observed at the end of the test.
CONCLUSIONSLow doses of transdermal estradiol exert no influence on fasting leptin levels or BMI. The possibility that different doses of estradiol exert a more pronounced effect on circulating leptin needs to be addressed in comparative studies.</description><subject>Administration, Cutaneous</subject><subject>Body Composition</subject><subject>Body Water - drug effects</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Estradiol - administration & dosage</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Leptin - blood</subject><subject>Middle Aged</subject><subject>Postmenopause - drug effects</subject><subject>Postmenopause - metabolism</subject><issn>1072-3714</issn><issn>1530-0374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctuFDEQRS1ERELgF5BXrGgoPxq32aGIR6RIbJK15barmQZ3u_GDUb4gv42HGWDFwrKv69yyXJcQyuA1A63eAIDkTPOOA3BgTXZtMXhELlgvmhBKPm5nULwTislz8jTnbw3hmqsn5JwxpRkMwwV5uF6nUHF1SONES7Jr9pgWGyjmpvwcA51XWnZIE36twZY5rgc04FZaIeBPDPlwscVcFlzjZmtu9n1s4h211Mc6BuzGMK_-Fd2CdTjGzsW1pBgCeppL9ffPyNlkQ8bnp_2S3H38cHv1ubv58un66v1N50T_FjoBPTIQAKgHyweluRZCg1XYOz8pdKC1YNpqJoWWo_ZTzwS3g3IoJedSXJKXx75bij9q-6NZ5uwwBLtirNkoJrTWIBo4HEGXYs4JJ7OlebHp3jAwhxDMnxDM3xDM7xCa9cXpjTou6P8ZT1NvgDwC-xgKpvw91D0ms0Mbys78L1zxC4Bmksg</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Cagnacci, Angelo</creator><creator>Malmusi, Stefania</creator><creator>Arangino, Serenella</creator><creator>Zanni, Annalisa</creator><creator>Rovati, Lucio</creator><creator>Cagnacci, Paolo</creator><creator>Volpe, Annibale</creator><general>The North American Menopause Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study</title><author>Cagnacci, Angelo ; Malmusi, Stefania ; Arangino, Serenella ; Zanni, Annalisa ; Rovati, Lucio ; Cagnacci, Paolo ; Volpe, Annibale</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3560-305e10300e98a2879293390a7e5cdf7ec099319a914394b9df5132a87ce442243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Cutaneous</topic><topic>Body Composition</topic><topic>Body Water - drug effects</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Estradiol - administration & dosage</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Leptin - blood</topic><topic>Middle Aged</topic><topic>Postmenopause - drug effects</topic><topic>Postmenopause - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cagnacci, Angelo</creatorcontrib><creatorcontrib>Malmusi, Stefania</creatorcontrib><creatorcontrib>Arangino, Serenella</creatorcontrib><creatorcontrib>Zanni, Annalisa</creatorcontrib><creatorcontrib>Rovati, Lucio</creatorcontrib><creatorcontrib>Cagnacci, Paolo</creatorcontrib><creatorcontrib>Volpe, Annibale</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Menopause (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cagnacci, Angelo</au><au>Malmusi, Stefania</au><au>Arangino, Serenella</au><au>Zanni, Annalisa</au><au>Rovati, Lucio</au><au>Cagnacci, Paolo</au><au>Volpe, Annibale</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study</atitle><jtitle>Menopause (New York, N.Y.)</jtitle><addtitle>Menopause</addtitle><date>2002-01</date><risdate>2002</risdate><volume>9</volume><issue>1</issue><spage>65</spage><epage>71</epage><pages>65-71</pages><issn>1072-3714</issn><eissn>1530-0374</eissn><abstract>OBJECTIVETo investigate whether the administration of transdermal estradiol is capable of modifying circulating levels of leptin.
DESIGNForty postmenopausal women randomly received in a double-blind fashion, a transdermal patch containing either placebo or estradiol (50 μg/day). After 2 months of treatment, they were switched to the alternate treatment for another 2 months. Leptin levels were measured at the end of the placebo and estradiol administration. In a subset of 28 women an evaluation of body composition via bioelectrical impedance and an oral glucose tolerance test (OGTT; 75 g) were also performed at the end of the placebo and estradiol administration. Glucose, insulin, and leptin levels were measured in all OGTT samples.
RESULTSLeptin levels were related directly to body mass index (BMI), fat mass, and insulin, and inversely related to lean mass. In comparison to placebo, transdermal estradiol increased estradiol (from 77.8 ± 8.4 pmol/l to 183.1 ± 20.9 pmol/l;p < 0.0001) but did not significantly modify leptin (19.1 ± 2.4 μg/l vs. 18.6 ± 2 μg/l) or BMI. Estradiol did not modify fat mass or lean mass, significantly increased intracellular water (31.1 ± 0.7% vs. 37.2 ± 2.3%, p < 0.05), and decreased extracellular water (40.5 ± 0.7% vs. 36.3 ± 1.7%;p < 0.04). Leptin did not increase during OGTT, but a significant decrease, linearly related to BMI (r = 0.519;p = 0.0189), was observed at the end of the test.
CONCLUSIONSLow doses of transdermal estradiol exert no influence on fasting leptin levels or BMI. The possibility that different doses of estradiol exert a more pronounced effect on circulating leptin needs to be addressed in comparative studies.</abstract><cop>United States</cop><pub>The North American Menopause Society</pub><pmid>11791088</pmid><doi>10.1097/00042192-200201000-00010</doi><tpages>7</tpages></addata></record> |
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subjects | Administration, Cutaneous Body Composition Body Water - drug effects Cross-Over Studies Double-Blind Method Estradiol - administration & dosage Fasting - blood Female Glucose Tolerance Test Humans Insulin - blood Leptin - blood Middle Aged Postmenopause - drug effects Postmenopause - metabolism |
title | Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study |
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