Mice deficient in apolipoprotein E but not LDL receptors are resistant to accelerated atherosclerosis associated with obesity

The aims of this study were to determine whether mice induced to become obese also exhibited accelerated atherosclerosis, and to determine whether obesity itself or dyslipidemia associated with obesity enhanced atherosclerosis. Wild-type (C57BL/6) mice and mice deficient for the low density lipoprot...

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Veröffentlicht in:	Atherosclerosis 2003-11, Vol.171 (1), p.49-55
Hauptverfasser:	Schreyer, Sandra A., Lystig, Theodore C., Vick, Cynthia M., LeBoeuf, Renée C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins B - drug effects Apolipoproteins B - metabolism Apolipoproteins E - blood Apolipoproteins E - deficiency Apolipoproteins E - drug effects Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Body Weight - drug effects Cardiology. Vascular system Chromatography, High Pressure Liquid Coronary Artery Disease - immunology Coronary Artery Disease - metabolism Dietary Fats - administration & dosage Dietary Fats - adverse effects Disease Models, Animal Disease Susceptibility Dyslipidemia Hyperlipidemias - etiology Hyperlipidemias - metabolism Immunity, Innate Lipoprotein Lipoproteins, HDL - drug effects Lipoproteins, HDL - metabolism Lipoproteins, LDL - drug effects Lipoproteins, LDL - metabolism Lipoproteins, VLDL - drug effects Lipoproteins, VLDL - metabolism Magnetic Resonance Spectroscopy Male Medical sciences Mice Mice, Inbred C57BL Models, Cardiovascular Obesity Obesity - immunology Obesity - metabolism Predictive Value of Tests Receptors, LDL - blood Receptors, LDL - deficiency Receptors, LDL - drug effects Statistics as Topic Triglycerides - metabolism
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