Pheochromocytoma Producing Vasoactive Intestinal Peptide
The syndrome of watery diarrhea associated with hypokalemia and achlorhydria was originally described in 1958. Subsequently, this syndrome was shown to be caused by a neuroendocrine tumor secreting vasoactive intestinal peptide (VIP), and such tumors are almost always pancreatic in origin. We descri...
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| Veröffentlicht in: | Mayo Clinic proceedings 2002, Vol.77 (1), p.97-100 |
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| creator | Smith, Stephen L. Slappy, A.L. Jackson Fox, Thomas P. Scolapio, James S. |
| description | The syndrome of watery diarrhea associated with hypokalemia and achlorhydria was originally described in 1958. Subsequently, this syndrome was shown to be caused by a neuroendocrine tumor secreting vasoactive intestinal peptide (VIP), and such tumors are almost always pancreatic in origin. We describe the case of a 78-year-old woman with gradual onset of hypokalemia, watery diarrhea, and weight loss. After a left adrenal mass was discovered, the patient chose medical therapy over surgical intervention. Initially her condition responded, then gradually became refractory to medical therapy. She had elevated levels of VIP, pancreatic polypeptide, dopamine, and vanillylmandelic acid. Subsequently, the patient underwent surgical excision of the mass that was found to be a VIP-producing pheochromocytoma. After surgery her diarrhea subsided, and her electrolytes and affected neuroendocrine hormone levels normalized. |
| doi_str_mv | 10.4065/77.1.97 |
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Jackson ; Fox, Thomas P. ; Scolapio, James S.</creator><creatorcontrib>Smith, Stephen L. ; Slappy, A.L. Jackson ; Fox, Thomas P. ; Scolapio, James S.</creatorcontrib><description>The syndrome of watery diarrhea associated with hypokalemia and achlorhydria was originally described in 1958. Subsequently, this syndrome was shown to be caused by a neuroendocrine tumor secreting vasoactive intestinal peptide (VIP), and such tumors are almost always pancreatic in origin. We describe the case of a 78-year-old woman with gradual onset of hypokalemia, watery diarrhea, and weight loss. After a left adrenal mass was discovered, the patient chose medical therapy over surgical intervention. Initially her condition responded, then gradually became refractory to medical therapy. She had elevated levels of VIP, pancreatic polypeptide, dopamine, and vanillylmandelic acid. Subsequently, the patient underwent surgical excision of the mass that was found to be a VIP-producing pheochromocytoma. After surgery her diarrhea subsided, and her electrolytes and affected neuroendocrine hormone levels normalized.</description><identifier>ISSN: 0025-6196</identifier><identifier>EISSN: 1942-5546</identifier><identifier>DOI: 10.4065/77.1.97</identifier><identifier>PMID: 11795252</identifier><identifier>CODEN: MACPAJ</identifier><language>eng</language><publisher>Rochester, MN: Elsevier Inc</publisher><subject>Adrenal Gland Neoplasms - metabolism ; Adrenal Gland Neoplasms - pathology ; Adrenal Gland Neoplasms - surgery ; Aged ; Biological and medical sciences ; Diarrhea - etiology ; Endocrinology ; Female ; Humans ; Hypokalemia - etiology ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pheochromocytoma - metabolism ; Pheochromocytoma - pathology ; Pheochromocytoma - surgery ; Vasoactive Intestinal Peptide - metabolism</subject><ispartof>Mayo Clinic proceedings, 2002, Vol.77 (1), p.97-100</ispartof><rights>2002 Mayo Foundation for Medical Education and Research</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Mayo Foundation for Medical Education and Research Jan 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-1ccc89adb191af51ff5e663d2616a743b2dcd17889b2a0ef5f6a1c58c7fe6df63</citedby><cites>FETCH-LOGICAL-c409t-1ccc89adb191af51ff5e663d2616a743b2dcd17889b2a0ef5f6a1c58c7fe6df63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/216879691?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13463515$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11795252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Stephen L.</creatorcontrib><creatorcontrib>Slappy, A.L. Jackson</creatorcontrib><creatorcontrib>Fox, Thomas P.</creatorcontrib><creatorcontrib>Scolapio, James S.</creatorcontrib><title>Pheochromocytoma Producing Vasoactive Intestinal Peptide</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>The syndrome of watery diarrhea associated with hypokalemia and achlorhydria was originally described in 1958. Subsequently, this syndrome was shown to be caused by a neuroendocrine tumor secreting vasoactive intestinal peptide (VIP), and such tumors are almost always pancreatic in origin. We describe the case of a 78-year-old woman with gradual onset of hypokalemia, watery diarrhea, and weight loss. After a left adrenal mass was discovered, the patient chose medical therapy over surgical intervention. Initially her condition responded, then gradually became refractory to medical therapy. She had elevated levels of VIP, pancreatic polypeptide, dopamine, and vanillylmandelic acid. Subsequently, the patient underwent surgical excision of the mass that was found to be a VIP-producing pheochromocytoma. After surgery her diarrhea subsided, and her electrolytes and affected neuroendocrine hormone levels normalized.</description><subject>Adrenal Gland Neoplasms - metabolism</subject><subject>Adrenal Gland Neoplasms - pathology</subject><subject>Adrenal Gland Neoplasms - surgery</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Diarrhea - etiology</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypokalemia - etiology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Pheochromocytoma - metabolism</subject><subject>Pheochromocytoma - pathology</subject><subject>Pheochromocytoma - surgery</subject><subject>Vasoactive Intestinal Peptide - metabolism</subject><issn>0025-6196</issn><issn>1942-5546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpl0F9LHDEUBfBQFF2t9BuURag-zTY3M0kmjyL1Dwjdh7avIXtzUyMzkzWZEfz2nbILgj7dlx_nHg5jX4CvGq7kd61XsDL6E1uAaUQlZaMO2IJzISsFRh2zk1KeOOfamOaIHQNoI4UUC9auHynhY059wtcx9W65zslPGIe_yz-uJIdjfKHl_TBSGePguuWatmP09JkdBtcVOtvfU_b75sev67vq4eft_fXVQ4UNN2MFiNga5zdgwAUJIUhSqvZCgXK6qTfCowfdtmYjHKcgg3KAskUdSPmg6lN2scvd5vQ8zSVsHwtS17mB0lSshtroVjQzPH8Hn9KU58bFClCtNsrAjC53CHMqJVOw2xx7l18tcPt_Sau1BWv0LL_u46ZNT_7N7aebwbc9cAVdF7IbMJY3VzeqliBnBztH80ovkbItGGlA8jETjtan-OH5P_d-iv4</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Smith, Stephen L.</creator><creator>Slappy, A.L. 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Jackson ; Fox, Thomas P. ; Scolapio, James S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-1ccc89adb191af51ff5e663d2616a743b2dcd17889b2a0ef5f6a1c58c7fe6df63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adrenal Gland Neoplasms - metabolism</topic><topic>Adrenal Gland Neoplasms - pathology</topic><topic>Adrenal Gland Neoplasms - surgery</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Diarrhea - etiology</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypokalemia - etiology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. 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| subjects | Adrenal Gland Neoplasms - metabolism Adrenal Gland Neoplasms - pathology Adrenal Gland Neoplasms - surgery Aged Biological and medical sciences Diarrhea - etiology Endocrinology Female Humans Hypokalemia - etiology Investigative techniques, diagnostic techniques (general aspects) Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pheochromocytoma - metabolism Pheochromocytoma - pathology Pheochromocytoma - surgery Vasoactive Intestinal Peptide - metabolism |
| title | Pheochromocytoma Producing Vasoactive Intestinal Peptide |
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