The use of HSP70 for prevention of consequences of unavoidable stress in rats

We studied whether intranasal treatment with HSP70 can be used for the correction of maladaptive behavior in rats after unavoidable stress. After 3 intranasal injection of HSP70 in a dose of 3.25 microg we observed normalization of adaptive behavior after unavoidable stress and improvement of physio...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2003-08, Vol.136 (2), p.120-122
Hauptverfasser:	Flerov, M A, Ordyan, N E, Margulis, B A, Guzhova, I V, V'yushina, A V, Pivina, S G, Gerasimova, I A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Behavior, Animal - physiology Electric Stimulation Helplessness, Learned HSP70 Heat-Shock Proteins - administration & dosage HSP70 Heat-Shock Proteins - metabolism HSP70 Heat-Shock Proteins - pharmacology Male Rats Rats, Wistar Stress, Psychological - drug therapy
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Beschreibung
Zusammenfassung:	We studied whether intranasal treatment with HSP70 can be used for the correction of maladaptive behavior in rats after unavoidable stress. After 3 intranasal injection of HSP70 in a dose of 3.25 microg we observed normalization of adaptive behavior after unavoidable stress and improvement of physiological reserves of the organism.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1026394218471