Interleukin-10 Receptor Signaling through STAT-3 Regulates the Apoptosis of Retinal Ganglion Cells in Response to Stress

Interleukin (IL)-10 has recently been shown to promote survival of neurons and glia. The purpose of this report is to investigate whether IL-10 has any role in protecting retinal ganglion cells (RGCs) from death under conditions in which growth factors are removed, or in which oxidative stress is pr...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2003-12, Vol.44 (12), p.5206-5211
Hauptverfasser:	Boyd, Zachary S, Kriatchko, Aleksie, Yang, Junjie, Agarwal, Neeraj, Wax, Martin B, Patil, Rajkumar V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Blotting, Western Cell Survival - drug effects Cells, Cultured Cytoprotection Dexamethasone - pharmacology DNA-Binding Proteins - metabolism Eye and associated structures. Visual pathways and centers. Vision Flow Cytometry Fundamental and applied biological sciences. Psychology Glucocorticoids - pharmacology Immunohistochemistry Insulin-Like Growth Factor I - pharmacology Interleukin-10 - pharmacology Oxidative Stress Phosphorylation Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Rats Receptors, Interleukin - metabolism Receptors, Interleukin-10 Retinal Ganglion Cells - cytology Retinal Ganglion Cells - metabolism Signal Transduction STAT3 Transcription Factor Tetrazolium Salts Thiazoles Trans-Activators - metabolism Vertebrates: nervous system and sense organs
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