Inhibition of Th1- and Th2-Mediated Airway Inflammation by the Sphingosine 1-Phosphate Receptor Agonist FTY720

The sphingosine 1-phosphate receptor agonist FTY720 is a novel immunomodulator that sequesters lymphocytes in secondary lymphoid organs and thereby prevents their migration to sites of inflammation. However, there is currently no information available on whether this drug affects Th1 or Th2 cell-med...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2003-12, Vol.171 (11), p.6206-6214
Hauptverfasser:	Sawicka, Elzbieta, Zuany-Amorim, Claudia, Manlius, Corinne, Trifilieff, Alexandre, Brinkmann, Volker, Kemeny, David M, Walker, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Asthma - drug therapy Asthma - immunology Asthma - pathology Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - prevention & control Bystander Effect - drug effects Bystander Effect - immunology Cell Movement - drug effects Cell Movement - immunology Disease Models, Animal Epitopes, T-Lymphocyte - immunology Fingolimod Hydrochloride Immunosuppressive Agents - administration & dosage Inflammation - immunology Inflammation - metabolism Inflammation - prevention & control Lung - drug effects Lung - immunology Lung - metabolism Lung - pathology Mice Mice, Inbred C57BL Mice, Transgenic Propylene Glycols - administration & dosage Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - biosynthesis Receptors, Lysophospholipid Sphingosine - metabolism Th1 Cells - drug effects Th1 Cells - metabolism Th1 Cells - transplantation Th2 Cells - drug effects Th2 Cells - metabolism Th2 Cells - transplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!