Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model

Objective Antiphospholipid antibodies (aPL) have thrombogenic properties in vivo, through their interactions with soluble coagulation factors and their ability to modulate the functions of cells involved in coagulation homeostasis. These antibodies have also been shown to enhance the adhesion of leu...

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Veröffentlicht in:	Arthritis and rheumatism 2003-11, Vol.48 (11), p.3272-3279
Hauptverfasser:	Ferrara, Dardo E., Liu, Xiaowei, Espinola, Ricardo G., Meroni, Pier Luigi, Abukhalaf, Imad, Harris, E. Nigel, Pierangeli, Silvia S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antibodies, Antiphospholipid - pharmacology Antiphospholipid Syndrome - immunology Biological and medical sciences Cell Adhesion - drug effects Disease Models, Animal Diseases of the osteoarticular system Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Fatty Acids, Monounsaturated - administration & dosage Fatty Acids, Monounsaturated - therapeutic use Hematologic and hematopoietic diseases Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Indoles - administration & dosage Indoles - therapeutic use Intercellular Adhesion Molecule-1 - blood Leukocytes - drug effects Male Medical sciences Mice Mice, Inbred Strains Microcirculation - drug effects Muscle, Skeletal - blood supply Platelet diseases and coagulopathies Thrombosis - drug therapy Thrombosis - immunology Thrombosis - pathology
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