Short-term liver function after biliopancreatic diversion
Liver failure after biliopancreatic diversion (BPD) has been reported. Although in our series of 2,515 BPD with a minimum follow-up of 12 months we have never observed this complication, a transitory and significant rise in serum AST and ALT has been detected in some cases, suggesting the occurrence...
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| Veröffentlicht in: | Obesity surgery 2003-10, Vol.13 (5), p.752-755 |
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| creator | Papadia, Francesco Marinari, Giuseppe M Camerini, Giovanni Adami, Gian Franco Murelli, Federica Carlini, Flavia Stabilini, Cesare Scopinaro, Nicola |
| description | Liver failure after biliopancreatic diversion (BPD) has been reported. Although in our series of 2,515 BPD with a minimum follow-up of 12 months we have never observed this complication, a transitory and significant rise in serum AST and ALT has been detected in some cases, suggesting the occurrence of transient liver damage. To assess if risk factors for acute liver damage after BPD could be identified, we studied the evolution of hepatic biochemistry in a sample of our operated subjects.
We studied 99 consecutive patients submitted to the same type of BPD (ad hoc stomach, ad hoc alimentary limb). Patients with a history of alcohol consumption or positive hepatic serology were excluded. Preoperative body weight (BW), body mass index (BMI), excess weight (EW), % excess weight (%EW), fasting serum glucose level (SG), hepatic histology (HI), weight loss (WL) at 2, 4 and 12 months, and excess weight % loss (IEW%L) at the same time were correlated with preoperative and 2, 4 and 12 months hepatic biochemistry.
Compared with preoperative values, AST levels at 2 months significantly increased (Student's t-test, P=0.0003) and significantly decreased at 12 months (P=0.0001). Spearman's Rank test showed significant correlations between 2 months AST levels and WL at 2 months (P =0.005), preoperative BW (P |
| doi_str_mv | 10.1381/096089203322509336 |
| format | Article |
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We studied 99 consecutive patients submitted to the same type of BPD (ad hoc stomach, ad hoc alimentary limb). Patients with a history of alcohol consumption or positive hepatic serology were excluded. Preoperative body weight (BW), body mass index (BMI), excess weight (EW), % excess weight (%EW), fasting serum glucose level (SG), hepatic histology (HI), weight loss (WL) at 2, 4 and 12 months, and excess weight % loss (IEW%L) at the same time were correlated with preoperative and 2, 4 and 12 months hepatic biochemistry.
Compared with preoperative values, AST levels at 2 months significantly increased (Student's t-test, P=0.0003) and significantly decreased at 12 months (P=0.0001). Spearman's Rank test showed significant correlations between 2 months AST levels and WL at 2 months (P =0.005), preoperative BW (P <0.0001), SG (P =0.01), and HI (inflammation P<0.0001, fibrosis P=0.001).
Hepatocellular necrosis in our series peaks at 2 months, and decreases afterwards.WL at 2 months, preoperative BW, SG and HI seem to be of help in identifying patients at increased risk for acute liver damage, prompting the need for an enhanced surveillance.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1381/096089203322509336</identifier><identifier>PMID: 14627471</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adolescent ; Adult ; Biliopancreatic Diversion - adverse effects ; Female ; Gastrointestinal surgery ; Humans ; Liver ; Liver - pathology ; Liver - physiopathology ; Liver Failure - epidemiology ; Liver Failure - etiology ; Male ; Middle Aged ; Morbidity ; Necrosis ; Obesity ; Risk Factors ; Surgical outcomes</subject><ispartof>Obesity surgery, 2003-10, Vol.13 (5), p.752-755</ispartof><rights>Springer 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-1f38624d6d3f7bb58c577ca3a731860f649ea2f0bd4dab2be8208eff8857575b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14627471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papadia, Francesco</creatorcontrib><creatorcontrib>Marinari, Giuseppe M</creatorcontrib><creatorcontrib>Camerini, Giovanni</creatorcontrib><creatorcontrib>Adami, Gian Franco</creatorcontrib><creatorcontrib>Murelli, Federica</creatorcontrib><creatorcontrib>Carlini, Flavia</creatorcontrib><creatorcontrib>Stabilini, Cesare</creatorcontrib><creatorcontrib>Scopinaro, Nicola</creatorcontrib><title>Short-term liver function after biliopancreatic diversion</title><title>Obesity surgery</title><addtitle>Obes Surg</addtitle><description>Liver failure after biliopancreatic diversion (BPD) has been reported. Although in our series of 2,515 BPD with a minimum follow-up of 12 months we have never observed this complication, a transitory and significant rise in serum AST and ALT has been detected in some cases, suggesting the occurrence of transient liver damage. To assess if risk factors for acute liver damage after BPD could be identified, we studied the evolution of hepatic biochemistry in a sample of our operated subjects.
We studied 99 consecutive patients submitted to the same type of BPD (ad hoc stomach, ad hoc alimentary limb). Patients with a history of alcohol consumption or positive hepatic serology were excluded. Preoperative body weight (BW), body mass index (BMI), excess weight (EW), % excess weight (%EW), fasting serum glucose level (SG), hepatic histology (HI), weight loss (WL) at 2, 4 and 12 months, and excess weight % loss (IEW%L) at the same time were correlated with preoperative and 2, 4 and 12 months hepatic biochemistry.
Compared with preoperative values, AST levels at 2 months significantly increased (Student's t-test, P=0.0003) and significantly decreased at 12 months (P=0.0001). Spearman's Rank test showed significant correlations between 2 months AST levels and WL at 2 months (P =0.005), preoperative BW (P <0.0001), SG (P =0.01), and HI (inflammation P<0.0001, fibrosis P=0.001).
Hepatocellular necrosis in our series peaks at 2 months, and decreases afterwards.WL at 2 months, preoperative BW, SG and HI seem to be of help in identifying patients at increased risk for acute liver damage, prompting the need for an enhanced surveillance.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biliopancreatic Diversion - adverse effects</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - pathology</subject><subject>Liver - physiopathology</subject><subject>Liver Failure - epidemiology</subject><subject>Liver Failure - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Necrosis</subject><subject>Obesity</subject><subject>Risk Factors</subject><subject>Surgical outcomes</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNplkE1LxDAQhoMo7rr6BzxI8eCtmkzaJD3Ksn7Aggf1HJI0wSxtsyat4L83yy4IyhwGZp53GB6ELgm-JVSQO9wwLBrAlALUuKGUHaE54ViUuAJxjOY7oMwEnaGzlDYYA2EAp2hGKga84mSOmtePEMdytLEvOv9lY-GmwYw-DIVyeVpo3_mwVYOJVo3eFO0OSnl_jk6c6pK9OPQFen9YvS2fyvXL4_Pyfl0aCmwsiaOCQdWyljqudS1MzblRVHFKBMOOVY1V4LBuq1Zp0FYAFtY5IWqeS9MFutnf3cbwOdk0yt4nY7tODTZMSfLsouGMZPD6D7gJUxzyb1IAwQ2IrGiBYA-ZGFKK1slt9L2K35JgubMq_1vNoavD5Un3tv2NHDTSHy0scTs</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Papadia, Francesco</creator><creator>Marinari, Giuseppe M</creator><creator>Camerini, Giovanni</creator><creator>Adami, Gian Franco</creator><creator>Murelli, Federica</creator><creator>Carlini, Flavia</creator><creator>Stabilini, Cesare</creator><creator>Scopinaro, Nicola</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200310</creationdate><title>Short-term liver function after biliopancreatic diversion</title><author>Papadia, Francesco ; Marinari, Giuseppe M ; Camerini, Giovanni ; Adami, Gian Franco ; Murelli, Federica ; Carlini, Flavia ; Stabilini, Cesare ; Scopinaro, Nicola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-1f38624d6d3f7bb58c577ca3a731860f649ea2f0bd4dab2be8208eff8857575b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biliopancreatic Diversion - adverse effects</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - pathology</topic><topic>Liver - physiopathology</topic><topic>Liver Failure - epidemiology</topic><topic>Liver Failure - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Necrosis</topic><topic>Obesity</topic><topic>Risk Factors</topic><topic>Surgical outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papadia, Francesco</creatorcontrib><creatorcontrib>Marinari, Giuseppe M</creatorcontrib><creatorcontrib>Camerini, Giovanni</creatorcontrib><creatorcontrib>Adami, Gian Franco</creatorcontrib><creatorcontrib>Murelli, Federica</creatorcontrib><creatorcontrib>Carlini, Flavia</creatorcontrib><creatorcontrib>Stabilini, Cesare</creatorcontrib><creatorcontrib>Scopinaro, Nicola</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papadia, Francesco</au><au>Marinari, Giuseppe M</au><au>Camerini, Giovanni</au><au>Adami, Gian Franco</au><au>Murelli, Federica</au><au>Carlini, Flavia</au><au>Stabilini, Cesare</au><au>Scopinaro, Nicola</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-term liver function after biliopancreatic diversion</atitle><jtitle>Obesity surgery</jtitle><addtitle>Obes Surg</addtitle><date>2003-10</date><risdate>2003</risdate><volume>13</volume><issue>5</issue><spage>752</spage><epage>755</epage><pages>752-755</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Liver failure after biliopancreatic diversion (BPD) has been reported. Although in our series of 2,515 BPD with a minimum follow-up of 12 months we have never observed this complication, a transitory and significant rise in serum AST and ALT has been detected in some cases, suggesting the occurrence of transient liver damage. To assess if risk factors for acute liver damage after BPD could be identified, we studied the evolution of hepatic biochemistry in a sample of our operated subjects.
We studied 99 consecutive patients submitted to the same type of BPD (ad hoc stomach, ad hoc alimentary limb). Patients with a history of alcohol consumption or positive hepatic serology were excluded. Preoperative body weight (BW), body mass index (BMI), excess weight (EW), % excess weight (%EW), fasting serum glucose level (SG), hepatic histology (HI), weight loss (WL) at 2, 4 and 12 months, and excess weight % loss (IEW%L) at the same time were correlated with preoperative and 2, 4 and 12 months hepatic biochemistry.
Compared with preoperative values, AST levels at 2 months significantly increased (Student's t-test, P=0.0003) and significantly decreased at 12 months (P=0.0001). Spearman's Rank test showed significant correlations between 2 months AST levels and WL at 2 months (P =0.005), preoperative BW (P <0.0001), SG (P =0.01), and HI (inflammation P<0.0001, fibrosis P=0.001).
Hepatocellular necrosis in our series peaks at 2 months, and decreases afterwards.WL at 2 months, preoperative BW, SG and HI seem to be of help in identifying patients at increased risk for acute liver damage, prompting the need for an enhanced surveillance.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>14627471</pmid><doi>10.1381/096089203322509336</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Biliopancreatic Diversion - adverse effects Female Gastrointestinal surgery Humans Liver Liver - pathology Liver - physiopathology Liver Failure - epidemiology Liver Failure - etiology Male Middle Aged Morbidity Necrosis Obesity Risk Factors Surgical outcomes |
| title | Short-term liver function after biliopancreatic diversion |
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