ABO and P1 Blood Group Antigen Expression and stx Genotype and Outcome of Childhood Escherichia coli O157:H7 Infections
P1 and ABO antigens and bacterial stx genotypes might influence the risk of developing hemolytic uremic syndrome (HUS) after Escherichia coli O157:H7 infections. We determined ABO status and P1 antigen expression in 130 infected and 17 uninfected children, and we determined the stx genotype of the i...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-01, Vol.185 (2), p.214-219 |
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| container_title | The Journal of infectious diseases |
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| creator | Jelacic, Srdjan Wobbe, Cheryl L. Boster, Daniel R. Ciol, Marcia A. Watkins, Sandra L. Tarr, Phillip I. Stapleton, Ann E. |
| description | P1 and ABO antigens and bacterial stx genotypes might influence the risk of developing hemolytic uremic syndrome (HUS) after Escherichia coli O157:H7 infections. We determined ABO status and P1 antigen expression in 130 infected and 17 uninfected children, and we determined the stx genotype of the infecting isolate. P1 expression was weakly and directly related to HUS risk (P=.04), but this risk did not extend to the group with the greatest P1 expression. P1 expression remained constant as HUS evolved. The ABO frequency was similar in all groups. These associations were not affected by the stx genotype. stx1−/stx2+E. coli O157:H7 strains were more commonly associated with HUS than were stx1+/stx2+ strains (P=.21), and 1 child with HUS was infected with a rare stx1+/stx2− isolate. In the present study, ABO antigens and stx genotypes were not major determinants of the outcome of E. coli O157:H7 infections, and P1 expression did not protect against the development of HUS |
| doi_str_mv | 10.1086/338480 |
| format | Article |
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We determined ABO status and P1 antigen expression in 130 infected and 17 uninfected children, and we determined the stx genotype of the infecting isolate. P1 expression was weakly and directly related to HUS risk (P=.04), but this risk did not extend to the group with the greatest P1 expression. P1 expression remained constant as HUS evolved. The ABO frequency was similar in all groups. These associations were not affected by the stx genotype. stx1−/stx2+E. coli O157:H7 strains were more commonly associated with HUS than were stx1+/stx2+ strains (P=.21), and 1 child with HUS was infected with a rare stx1+/stx2− isolate. In the present study, ABO antigens and stx genotypes were not major determinants of the outcome of E. coli O157:H7 infections, and P1 expression did not protect against the development of HUS</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/338480</identifier><identifier>PMID: 11807695</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>ABO Blood-Group System - analysis ; Antigens ; Antigens, Nuclear ; AP1 system ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Bacteriology ; Biological and medical sciences ; Blood group antigens ; Blood grouping ; Blood groups ; Child ; Child, Preschool ; Erythrocytes ; Escherichia coli ; Escherichia coli Infections - blood ; Escherichia coli Infections - etiology ; Escherichia coli O157 ; Female ; Fundamental and applied biological sciences. Psychology ; Genotype ; Genotypes ; Hemolytic uremic syndrome ; Hemolytic-Uremic Syndrome - etiology ; Human bacterial diseases ; Humans ; Infant ; Infections ; Infectious diseases ; Logistic Models ; Major Articles ; Male ; Medical sciences ; Microbiology ; Nuclear Proteins - analysis ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Prospective Studies ; Risk Factors ; Shiga Toxin - genetics ; Shiga toxins ; stx gene</subject><ispartof>The Journal of infectious diseases, 2002-01, Vol.185 (2), p.214-219</ispartof><rights>Copyright 2002 Infectious Diseases Society of America</rights><rights>2002 by the Infectious Diseases Society of America 2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-b6a8420323ff8725d7ee2292a1abbea0196540d026269529cd3d77120425001b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30137261$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30137261$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13426154$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11807695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jelacic, Srdjan</creatorcontrib><creatorcontrib>Wobbe, Cheryl L.</creatorcontrib><creatorcontrib>Boster, Daniel R.</creatorcontrib><creatorcontrib>Ciol, Marcia A.</creatorcontrib><creatorcontrib>Watkins, Sandra L.</creatorcontrib><creatorcontrib>Tarr, Phillip I.</creatorcontrib><creatorcontrib>Stapleton, Ann E.</creatorcontrib><title>ABO and P1 Blood Group Antigen Expression and stx Genotype and Outcome of Childhood Escherichia coli O157:H7 Infections</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>P1 and ABO antigens and bacterial stx genotypes might influence the risk of developing hemolytic uremic syndrome (HUS) after Escherichia coli O157:H7 infections. We determined ABO status and P1 antigen expression in 130 infected and 17 uninfected children, and we determined the stx genotype of the infecting isolate. P1 expression was weakly and directly related to HUS risk (P=.04), but this risk did not extend to the group with the greatest P1 expression. P1 expression remained constant as HUS evolved. The ABO frequency was similar in all groups. These associations were not affected by the stx genotype. stx1−/stx2+E. coli O157:H7 strains were more commonly associated with HUS than were stx1+/stx2+ strains (P=.21), and 1 child with HUS was infected with a rare stx1+/stx2− isolate. In the present study, ABO antigens and stx genotypes were not major determinants of the outcome of E. coli O157:H7 infections, and P1 expression did not protect against the development of HUS</description><subject>ABO Blood-Group System - analysis</subject><subject>Antigens</subject><subject>Antigens, Nuclear</subject><subject>AP1 system</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Blood group antigens</subject><subject>Blood grouping</subject><subject>Blood groups</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Erythrocytes</subject><subject>Escherichia coli</subject><subject>Escherichia coli Infections - blood</subject><subject>Escherichia coli Infections - etiology</subject><subject>Escherichia coli O157</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Hemolytic uremic syndrome</subject><subject>Hemolytic-Uremic Syndrome - etiology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Logistic Models</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Nuclear Proteins - analysis</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Shiga Toxin - genetics</subject><subject>Shiga toxins</subject><subject>stx gene</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U9v0zAYBnALgVgZ8A1A5gC3gP06_hNuXdW1E0NlCBDiYjmOQz3SONiJ6L492VKtJ8TJkp-fHsvvi9BzSt5SosQ7xlSuyAM0o5zJTAjKHqIZIQAZVUVxgp6kdE0IyZmQj9EJpYpIUfAZ-jM_22DTVvgTxWdNCBVexTB0eN72_qdr8XLfRZeSD-2dSv0er1wb-pvO3V1sht6GncOhxoutb6rtbcUy2a2L3m69wTY0Hm8ol-_XEl-0tbP9WJaeoke1aZJ7djhP0dfz5ZfFOrvcrC4W88vM5gB9VgqjciAMWF0rCbySzgEUYKgpS2cILQTPSUVAwPgdKGzFKikpkBw4IbRkp-jN1NvF8Htwqdc7n6xrGtO6MCQtKVMF4_BfSBWonAI7QhtDStHVuot-Z-KNpkTf7kJPuxjhy0PjUO5cdWSH4Y_g9QGYZE1TR9Nan46O5SAoz0f3anLjYv792IvJXKc-xHvFCGVybBnzbMp96t3-PjfxlxaSSa7X33_oDx-vzr99vlppzv4CCp2wBw</recordid><startdate>20020115</startdate><enddate>20020115</enddate><creator>Jelacic, Srdjan</creator><creator>Wobbe, Cheryl L.</creator><creator>Boster, Daniel R.</creator><creator>Ciol, Marcia A.</creator><creator>Watkins, Sandra L.</creator><creator>Tarr, Phillip I.</creator><creator>Stapleton, Ann E.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20020115</creationdate><title>ABO and P1 Blood Group Antigen Expression and stx Genotype and Outcome of Childhood Escherichia coli O157:H7 Infections</title><author>Jelacic, Srdjan ; Wobbe, Cheryl L. ; Boster, Daniel R. ; Ciol, Marcia A. ; Watkins, Sandra L. ; Tarr, Phillip I. ; Stapleton, Ann E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-b6a8420323ff8725d7ee2292a1abbea0196540d026269529cd3d77120425001b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>ABO Blood-Group System - analysis</topic><topic>Antigens</topic><topic>Antigens, Nuclear</topic><topic>AP1 system</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Blood group antigens</topic><topic>Blood grouping</topic><topic>Blood groups</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Erythrocytes</topic><topic>Escherichia coli</topic><topic>Escherichia coli Infections - blood</topic><topic>Escherichia coli Infections - etiology</topic><topic>Escherichia coli O157</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Hemolytic uremic syndrome</topic><topic>Hemolytic-Uremic Syndrome - etiology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Logistic Models</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Nuclear Proteins - analysis</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Shiga Toxin - genetics</topic><topic>Shiga toxins</topic><topic>stx gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jelacic, Srdjan</creatorcontrib><creatorcontrib>Wobbe, Cheryl L.</creatorcontrib><creatorcontrib>Boster, Daniel R.</creatorcontrib><creatorcontrib>Ciol, Marcia A.</creatorcontrib><creatorcontrib>Watkins, Sandra L.</creatorcontrib><creatorcontrib>Tarr, Phillip I.</creatorcontrib><creatorcontrib>Stapleton, Ann E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jelacic, Srdjan</au><au>Wobbe, Cheryl L.</au><au>Boster, Daniel R.</au><au>Ciol, Marcia A.</au><au>Watkins, Sandra L.</au><au>Tarr, Phillip I.</au><au>Stapleton, Ann E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ABO and P1 Blood Group Antigen Expression and stx Genotype and Outcome of Childhood Escherichia coli O157:H7 Infections</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2002-01-15</date><risdate>2002</risdate><volume>185</volume><issue>2</issue><spage>214</spage><epage>219</epage><pages>214-219</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>P1 and ABO antigens and bacterial stx genotypes might influence the risk of developing hemolytic uremic syndrome (HUS) after Escherichia coli O157:H7 infections. We determined ABO status and P1 antigen expression in 130 infected and 17 uninfected children, and we determined the stx genotype of the infecting isolate. P1 expression was weakly and directly related to HUS risk (P=.04), but this risk did not extend to the group with the greatest P1 expression. P1 expression remained constant as HUS evolved. The ABO frequency was similar in all groups. These associations were not affected by the stx genotype. stx1−/stx2+E. coli O157:H7 strains were more commonly associated with HUS than were stx1+/stx2+ strains (P=.21), and 1 child with HUS was infected with a rare stx1+/stx2− isolate. In the present study, ABO antigens and stx genotypes were not major determinants of the outcome of E. coli O157:H7 infections, and P1 expression did not protect against the development of HUS</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11807695</pmid><doi>10.1086/338480</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | ABO Blood-Group System - analysis Antigens Antigens, Nuclear AP1 system Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacteriology Biological and medical sciences Blood group antigens Blood grouping Blood groups Child Child, Preschool Erythrocytes Escherichia coli Escherichia coli Infections - blood Escherichia coli Infections - etiology Escherichia coli O157 Female Fundamental and applied biological sciences. Psychology Genotype Genotypes Hemolytic uremic syndrome Hemolytic-Uremic Syndrome - etiology Human bacterial diseases Humans Infant Infections Infectious diseases Logistic Models Major Articles Male Medical sciences Microbiology Nuclear Proteins - analysis Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Prospective Studies Risk Factors Shiga Toxin - genetics Shiga toxins stx gene |
| title | ABO and P1 Blood Group Antigen Expression and stx Genotype and Outcome of Childhood Escherichia coli O157:H7 Infections |
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