The multidrug resistance of In vitro tumor cell lines derived from human breast carcinoma MCF-7 does not influence pentavalent technetium-99m-dimercaptosuccinic acid uptake

The main causes of multidrug resistance (MDR) are overexpression of P-glycoprotein (P-gp) and multidrug resistance-associated protein isoform 1 (MRP1) often associated with high levels of glutathione (GSH). We investigated whether MDR phenotype can influence Tc-99m-(V)-DMSA [pentavalent technetium-9...

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Veröffentlicht in:	Cancer biotherapy & radiopharmaceuticals 2003-10, Vol.18 (5), p.791-802
Hauptverfasser:	DENOYER, Delphine, PEREK, Nathalie, LE JEUNE, Nathalie, FRERE, Delphine, DUBOIS, Francis
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Biological Transport - drug effects Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Doxorubicin - pharmacology Drug Resistance, Multiple Drug Resistance, Neoplasm General aspects (metabolism, cell proliferation, established cell line...) Glutathione - metabolism Glutathione - pharmacology Humans Kinetics Medical sciences Technetium Tc 99m Dimercaptosuccinic Acid - metabolism Technetium Tc 99m Sestamibi - metabolism Tumor cell Tumors
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