Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers
The number of clinical studies on gamma interferon (IFN-γ), tumor necrosis factor-alpha (TNF-α) and interleukin-4 (IL-4) in human brucellosis is limited. The present study was focused on IFN-γ, TNF-α and IL-4 levels in acute brucellosis cases, in the acute phase and at the end of the treatment. The...
Gespeichert in:
Veröffentlicht in: | FEMS immunology and medical microbiology 2003-11, Vol.39 (2), p.149-153 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 153 |
---|---|
container_issue | 2 |
container_start_page | 149 |
container_title | FEMS immunology and medical microbiology |
container_volume | 39 |
creator | Demirdag, Kutbettin Ozden, Mehmet Kalkan, Ahmet Godekmerdan, Ahmet Sirri Kilic, S |
description | The number of clinical studies on gamma interferon (IFN-γ), tumor necrosis factor-alpha (TNF-α) and interleukin-4 (IL-4) in human brucellosis is limited. The present study was focused on IFN-γ, TNF-α and IL-4 levels in acute brucellosis cases, in the acute phase and at the end of the treatment. The relation of these cytokines to traditional inflammation markers was also investigated. The study included 27 cases of acute brucellosis and 20 healthy volunteers who had no complaints. It was found that mean IFN-γ and TNF-α levels, CRP (C-reactive protein) levels and ESR (erythrocyte sedimentation rate) values were significantly higher in acute brucellosis cases as compared to post-treatment values and values measured in the control group. In addition, IFN-γ and TNF-α levels measured in the acute phase correlated with the increase in CRP levels and ESR values. Our results confirmed that IFN-γ and TNF-α are involved in the pathophysiology of brucellosis and are closely related to the inflammatory activation of the disease. In view of the present findings, it is suggested that IFN-γ and TNFα may be used for monitoring brucellosis. |
doi_str_mv | 10.1016/S0928-8244(03)00207-4 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71388339</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1016/S0928-8244(03)00207-4</oup_id><els_id>S0928824403002074</els_id><sourcerecordid>19237281</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5609-7f007e306926e3a9cf78c88147532c54925f0c7ed1e9c0cc30dd50436713384d3</originalsourceid><addsrcrecordid>eNqNkl9rFTEQxYMo9lr9CEpeFPuwOvm32TyJFFsLFR-q4FtIs7M0Nrt7TbIt99u7271YBKE-BYbfmZmTM4S8ZPCOAavfX4DhTdVwKd-COALgoCv5iGyY0rKqjfrxmGz-IAfkWc4_AUAagKfkgMmaKzDNhuQLTFNP_a6M12FAGvEGY6ZhoFtXAg4l09tQrqjzU0F6mSaPMY45ZOqGlpYrDIkmjDM7DrSMS4WW5NqwFFycG3XR9b0rY9rR3qVrTPk5edK5mPHF_j0k308-fTv-XJ1_PT07_nheeVWDqXQHoFFAbXiNwhnf6cY3DZNaCe6VNFx14DW2DI0H7wW0rQIpas2EaGQrDsmbte82jb8mzMX2IS_7uwHHKduZaxohzIMgM1xo3rAZVCvo05hzws5uU5hd7SwDu8Ri72Kxy59bEPYuFitn3av9gOmyx_Zetc9hBl7vAZe9i11ygw_5nlNcGzB65szK3YaIu_-bbk_OvjC5uIRVO07bfyurv5TVsveHVTLfBN4ETDb7-Sg8tiGhL7YdwwPOfwNyXckC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19237281</pqid></control><display><type>article</type><title>Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Demirdag, Kutbettin ; Ozden, Mehmet ; Kalkan, Ahmet ; Godekmerdan, Ahmet ; Sirri Kilic, S</creator><creatorcontrib>Demirdag, Kutbettin ; Ozden, Mehmet ; Kalkan, Ahmet ; Godekmerdan, Ahmet ; Sirri Kilic, S</creatorcontrib><description>The number of clinical studies on gamma interferon (IFN-γ), tumor necrosis factor-alpha (TNF-α) and interleukin-4 (IL-4) in human brucellosis is limited. The present study was focused on IFN-γ, TNF-α and IL-4 levels in acute brucellosis cases, in the acute phase and at the end of the treatment. The relation of these cytokines to traditional inflammation markers was also investigated. The study included 27 cases of acute brucellosis and 20 healthy volunteers who had no complaints. It was found that mean IFN-γ and TNF-α levels, CRP (C-reactive protein) levels and ESR (erythrocyte sedimentation rate) values were significantly higher in acute brucellosis cases as compared to post-treatment values and values measured in the control group. In addition, IFN-γ and TNF-α levels measured in the acute phase correlated with the increase in CRP levels and ESR values. Our results confirmed that IFN-γ and TNF-α are involved in the pathophysiology of brucellosis and are closely related to the inflammatory activation of the disease. In view of the present findings, it is suggested that IFN-γ and TNFα may be used for monitoring brucellosis.</description><identifier>ISSN: 0928-8244</identifier><identifier>EISSN: 1574-695X</identifier><identifier>DOI: 10.1016/S0928-8244(03)00207-4</identifier><identifier>PMID: 14625098</identifier><language>eng</language><publisher>Oxford, UK: Elsevier B.V</publisher><subject>Acute Disease ; Adolescent ; Adult ; Anti-Bacterial Agents - therapeutic use ; Biological and medical sciences ; Biomarkers - blood ; Blood Sedimentation ; Brucella ; Brucellosis ; Brucellosis - drug therapy ; Brucellosis - immunology ; Brucellosis - microbiology ; Brucellosis - physiopathology ; C-reactive protein ; C-Reactive Protein - analysis ; Cytokine ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Inflammatory marker ; Interferon-gamma - blood ; Interleukin-4 - blood ; Male ; Microbiology ; Middle Aged ; Treatment ; Tumor Necrosis Factor-alpha - analysis</subject><ispartof>FEMS immunology and medical microbiology, 2003-11, Vol.39 (2), p.149-153</ispartof><rights>2003 Federation of European Microbiological Societies</rights><rights>2003 Federation of European Microbiological Societies. 2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5609-7f007e306926e3a9cf78c88147532c54925f0c7ed1e9c0cc30dd50436713384d3</citedby><cites>FETCH-LOGICAL-c5609-7f007e306926e3a9cf78c88147532c54925f0c7ed1e9c0cc30dd50436713384d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0928-8244%2803%2900207-4$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2FS0928-8244%2803%2900207-4$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15279097$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14625098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demirdag, Kutbettin</creatorcontrib><creatorcontrib>Ozden, Mehmet</creatorcontrib><creatorcontrib>Kalkan, Ahmet</creatorcontrib><creatorcontrib>Godekmerdan, Ahmet</creatorcontrib><creatorcontrib>Sirri Kilic, S</creatorcontrib><title>Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers</title><title>FEMS immunology and medical microbiology</title><addtitle>FEMS Immunol Med Microbiol</addtitle><description>The number of clinical studies on gamma interferon (IFN-γ), tumor necrosis factor-alpha (TNF-α) and interleukin-4 (IL-4) in human brucellosis is limited. The present study was focused on IFN-γ, TNF-α and IL-4 levels in acute brucellosis cases, in the acute phase and at the end of the treatment. The relation of these cytokines to traditional inflammation markers was also investigated. The study included 27 cases of acute brucellosis and 20 healthy volunteers who had no complaints. It was found that mean IFN-γ and TNF-α levels, CRP (C-reactive protein) levels and ESR (erythrocyte sedimentation rate) values were significantly higher in acute brucellosis cases as compared to post-treatment values and values measured in the control group. In addition, IFN-γ and TNF-α levels measured in the acute phase correlated with the increase in CRP levels and ESR values. Our results confirmed that IFN-γ and TNF-α are involved in the pathophysiology of brucellosis and are closely related to the inflammatory activation of the disease. In view of the present findings, it is suggested that IFN-γ and TNFα may be used for monitoring brucellosis.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood Sedimentation</subject><subject>Brucella</subject><subject>Brucellosis</subject><subject>Brucellosis - drug therapy</subject><subject>Brucellosis - immunology</subject><subject>Brucellosis - microbiology</subject><subject>Brucellosis - physiopathology</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cytokine</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Inflammatory marker</subject><subject>Interferon-gamma - blood</subject><subject>Interleukin-4 - blood</subject><subject>Male</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Treatment</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>0928-8244</issn><issn>1574-695X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl9rFTEQxYMo9lr9CEpeFPuwOvm32TyJFFsLFR-q4FtIs7M0Nrt7TbIt99u7271YBKE-BYbfmZmTM4S8ZPCOAavfX4DhTdVwKd-COALgoCv5iGyY0rKqjfrxmGz-IAfkWc4_AUAagKfkgMmaKzDNhuQLTFNP_a6M12FAGvEGY6ZhoFtXAg4l09tQrqjzU0F6mSaPMY45ZOqGlpYrDIkmjDM7DrSMS4WW5NqwFFycG3XR9b0rY9rR3qVrTPk5edK5mPHF_j0k308-fTv-XJ1_PT07_nheeVWDqXQHoFFAbXiNwhnf6cY3DZNaCe6VNFx14DW2DI0H7wW0rQIpas2EaGQrDsmbte82jb8mzMX2IS_7uwHHKduZaxohzIMgM1xo3rAZVCvo05hzws5uU5hd7SwDu8Ri72Kxy59bEPYuFitn3av9gOmyx_Zetc9hBl7vAZe9i11ygw_5nlNcGzB65szK3YaIu_-bbk_OvjC5uIRVO07bfyurv5TVsveHVTLfBN4ETDb7-Sg8tiGhL7YdwwPOfwNyXckC</recordid><startdate>20031128</startdate><enddate>20031128</enddate><creator>Demirdag, Kutbettin</creator><creator>Ozden, Mehmet</creator><creator>Kalkan, Ahmet</creator><creator>Godekmerdan, Ahmet</creator><creator>Sirri Kilic, S</creator><general>Elsevier B.V</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20031128</creationdate><title>Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers</title><author>Demirdag, Kutbettin ; Ozden, Mehmet ; Kalkan, Ahmet ; Godekmerdan, Ahmet ; Sirri Kilic, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5609-7f007e306926e3a9cf78c88147532c54925f0c7ed1e9c0cc30dd50436713384d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood Sedimentation</topic><topic>Brucella</topic><topic>Brucellosis</topic><topic>Brucellosis - drug therapy</topic><topic>Brucellosis - immunology</topic><topic>Brucellosis - microbiology</topic><topic>Brucellosis - physiopathology</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cytokine</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Inflammatory marker</topic><topic>Interferon-gamma - blood</topic><topic>Interleukin-4 - blood</topic><topic>Male</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Treatment</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demirdag, Kutbettin</creatorcontrib><creatorcontrib>Ozden, Mehmet</creatorcontrib><creatorcontrib>Kalkan, Ahmet</creatorcontrib><creatorcontrib>Godekmerdan, Ahmet</creatorcontrib><creatorcontrib>Sirri Kilic, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS immunology and medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demirdag, Kutbettin</au><au>Ozden, Mehmet</au><au>Kalkan, Ahmet</au><au>Godekmerdan, Ahmet</au><au>Sirri Kilic, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers</atitle><jtitle>FEMS immunology and medical microbiology</jtitle><addtitle>FEMS Immunol Med Microbiol</addtitle><date>2003-11-28</date><risdate>2003</risdate><volume>39</volume><issue>2</issue><spage>149</spage><epage>153</epage><pages>149-153</pages><issn>0928-8244</issn><eissn>1574-695X</eissn><abstract>The number of clinical studies on gamma interferon (IFN-γ), tumor necrosis factor-alpha (TNF-α) and interleukin-4 (IL-4) in human brucellosis is limited. The present study was focused on IFN-γ, TNF-α and IL-4 levels in acute brucellosis cases, in the acute phase and at the end of the treatment. The relation of these cytokines to traditional inflammation markers was also investigated. The study included 27 cases of acute brucellosis and 20 healthy volunteers who had no complaints. It was found that mean IFN-γ and TNF-α levels, CRP (C-reactive protein) levels and ESR (erythrocyte sedimentation rate) values were significantly higher in acute brucellosis cases as compared to post-treatment values and values measured in the control group. In addition, IFN-γ and TNF-α levels measured in the acute phase correlated with the increase in CRP levels and ESR values. Our results confirmed that IFN-γ and TNF-α are involved in the pathophysiology of brucellosis and are closely related to the inflammatory activation of the disease. In view of the present findings, it is suggested that IFN-γ and TNFα may be used for monitoring brucellosis.</abstract><cop>Oxford, UK</cop><pub>Elsevier B.V</pub><pmid>14625098</pmid><doi>10.1016/S0928-8244(03)00207-4</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0928-8244 |
ispartof | FEMS immunology and medical microbiology, 2003-11, Vol.39 (2), p.149-153 |
issn | 0928-8244 1574-695X |
language | eng |
recordid | cdi_proquest_miscellaneous_71388339 |
source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Wiley Online Library All Journals; Alma/SFX Local Collection |
subjects | Acute Disease Adolescent Adult Anti-Bacterial Agents - therapeutic use Biological and medical sciences Biomarkers - blood Blood Sedimentation Brucella Brucellosis Brucellosis - drug therapy Brucellosis - immunology Brucellosis - microbiology Brucellosis - physiopathology C-reactive protein C-Reactive Protein - analysis Cytokine Female Fundamental and applied biological sciences. Psychology Humans Inflammatory marker Interferon-gamma - blood Interleukin-4 - blood Male Microbiology Middle Aged Treatment Tumor Necrosis Factor-alpha - analysis |
title | Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T03%3A34%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20cytokine%20levels%20in%20patients%20with%20acute%20brucellosis%20and%20their%20relation%20to%20the%20traditional%20inflammatory%20markers&rft.jtitle=FEMS%20immunology%20and%20medical%20microbiology&rft.au=Demirdag,%20Kutbettin&rft.date=2003-11-28&rft.volume=39&rft.issue=2&rft.spage=149&rft.epage=153&rft.pages=149-153&rft.issn=0928-8244&rft.eissn=1574-695X&rft_id=info:doi/10.1016/S0928-8244(03)00207-4&rft_dat=%3Cproquest_cross%3E19237281%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19237281&rft_id=info:pmid/14625098&rft_oup_id=10.1016/S0928-8244(03)00207-4&rft_els_id=S0928824403002074&rfr_iscdi=true |