Involvement of calcitonin gene-related peptide in elevation of skin temperature in castrated male rats
To assess the involvement of calcitonin gene-related peptide (CGRP) in the occurrence of hot flashes in men after castration for treatment of prostate cancer, we investigated the effects of CGRP on skin temperature in surgically and medically castrated male rats. Changes in skin temperature of the h...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 2003-11, Vol.62 (5), p.947-951 |
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| creator | Yuzurihara, Mitsutoshi Ikarashi, Yasushi Noguchi, Masamichi Kase, Yoshio Takeda, Shuichi Aburada, Masaki |
| description | To assess the involvement of calcitonin gene-related peptide (CGRP) in the occurrence of hot flashes in men after castration for treatment of prostate cancer, we investigated the effects of CGRP on skin temperature in surgically and medically castrated male rats.
Changes in skin temperature of the hind paws after intravenous injection of 10 μg/kg of CGRP and CGRP family peptides (adrenomedullin and amylin) were measured at 5-minute intervals for 120 minutes, 3 weeks after bilateral orchiectomy or 2 weeks after subcutaneous injection of a gonadotropin-releasing hormone analogue (1.0 mg/kg Leuplin) in male rats. Antagonism with CGRP
8-37 (1000 μg/kg intravenously), a CGRP
1 receptor antagonist, to the CGRP-induced response was examined by injecting it 10 minutes before injection of CGRP. The effect of testosterone replacement on castration was evaluated in each castrated rat by the administration of testosterone (1.0 mg/kg subcutaneously once a day) for 14 days before the day of the temperature analysis.
CGRP, but not adrenomedullin and amylin, elevated the skin temperature in surgical or medical castration-induced testosterone-deficient rats more than in the sham-treated rats. The difference was statistically significant. The CGRP-induced potentiation in the castrated rats was inhibited by pretreating with CGRP
8-37 or by supplying testosterone.
CGRP is the most potent peptide in a family that elevates the skin temperature in male rats. The elevation of the skin temperature was more affected by the testosterone deficiency resulting from castration. These results suggest that CGRP is involved in the mechanism underlying hot flashes in men. |
| doi_str_mv | 10.1016/S0090-4295(03)00587-9 |
| format | Article |
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Changes in skin temperature of the hind paws after intravenous injection of 10 μg/kg of CGRP and CGRP family peptides (adrenomedullin and amylin) were measured at 5-minute intervals for 120 minutes, 3 weeks after bilateral orchiectomy or 2 weeks after subcutaneous injection of a gonadotropin-releasing hormone analogue (1.0 mg/kg Leuplin) in male rats. Antagonism with CGRP
8-37 (1000 μg/kg intravenously), a CGRP
1 receptor antagonist, to the CGRP-induced response was examined by injecting it 10 minutes before injection of CGRP. The effect of testosterone replacement on castration was evaluated in each castrated rat by the administration of testosterone (1.0 mg/kg subcutaneously once a day) for 14 days before the day of the temperature analysis.
CGRP, but not adrenomedullin and amylin, elevated the skin temperature in surgical or medical castration-induced testosterone-deficient rats more than in the sham-treated rats. The difference was statistically significant. The CGRP-induced potentiation in the castrated rats was inhibited by pretreating with CGRP
8-37 or by supplying testosterone.
CGRP is the most potent peptide in a family that elevates the skin temperature in male rats. The elevation of the skin temperature was more affected by the testosterone deficiency resulting from castration. These results suggest that CGRP is involved in the mechanism underlying hot flashes in men.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/S0090-4295(03)00587-9</identifier><identifier>PMID: 14624932</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenomedullin ; Amyloid - administration & dosage ; Amyloid - pharmacology ; Animals ; Biological and medical sciences ; Calcitonin Gene-Related Peptide - administration & dosage ; Calcitonin Gene-Related Peptide - pharmacology ; Calcitonin Gene-Related Peptide - physiology ; Fundamental and applied biological sciences. Psychology ; Gonadotropin-Releasing Hormone - antagonists & inhibitors ; Hindlimb ; Hormone Antagonists - pharmacology ; Hormones and neuropeptides. Regulation ; Hot Flashes - physiopathology ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Injections, Intravenous ; Islet Amyloid Polypeptide ; Leuprolide - pharmacology ; Male ; Orchiectomy ; Peptide Fragments - pharmacology ; Peptides - administration & dosage ; Peptides - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Calcitonin Gene-Related Peptide - drug effects ; Skin Temperature - physiology ; Testosterone - pharmacology ; Vertebrates: endocrinology</subject><ispartof>Urology (Ridgewood, N.J.), 2003-11, Vol.62 (5), p.947-951</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-70e5bee672e543ad3fa6b76161febf2241b64c546499f3f2b4c2c57f0d416d303</citedby><cites>FETCH-LOGICAL-c391t-70e5bee672e543ad3fa6b76161febf2241b64c546499f3f2b4c2c57f0d416d303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0090-4295(03)00587-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15249297$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14624932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuzurihara, Mitsutoshi</creatorcontrib><creatorcontrib>Ikarashi, Yasushi</creatorcontrib><creatorcontrib>Noguchi, Masamichi</creatorcontrib><creatorcontrib>Kase, Yoshio</creatorcontrib><creatorcontrib>Takeda, Shuichi</creatorcontrib><creatorcontrib>Aburada, Masaki</creatorcontrib><title>Involvement of calcitonin gene-related peptide in elevation of skin temperature in castrated male rats</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>To assess the involvement of calcitonin gene-related peptide (CGRP) in the occurrence of hot flashes in men after castration for treatment of prostate cancer, we investigated the effects of CGRP on skin temperature in surgically and medically castrated male rats.
Changes in skin temperature of the hind paws after intravenous injection of 10 μg/kg of CGRP and CGRP family peptides (adrenomedullin and amylin) were measured at 5-minute intervals for 120 minutes, 3 weeks after bilateral orchiectomy or 2 weeks after subcutaneous injection of a gonadotropin-releasing hormone analogue (1.0 mg/kg Leuplin) in male rats. Antagonism with CGRP
8-37 (1000 μg/kg intravenously), a CGRP
1 receptor antagonist, to the CGRP-induced response was examined by injecting it 10 minutes before injection of CGRP. The effect of testosterone replacement on castration was evaluated in each castrated rat by the administration of testosterone (1.0 mg/kg subcutaneously once a day) for 14 days before the day of the temperature analysis.
CGRP, but not adrenomedullin and amylin, elevated the skin temperature in surgical or medical castration-induced testosterone-deficient rats more than in the sham-treated rats. The difference was statistically significant. The CGRP-induced potentiation in the castrated rats was inhibited by pretreating with CGRP
8-37 or by supplying testosterone.
CGRP is the most potent peptide in a family that elevates the skin temperature in male rats. The elevation of the skin temperature was more affected by the testosterone deficiency resulting from castration. These results suggest that CGRP is involved in the mechanism underlying hot flashes in men.</description><subject>Adrenomedullin</subject><subject>Amyloid - administration & dosage</subject><subject>Amyloid - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcitonin Gene-Related Peptide - administration & dosage</subject><subject>Calcitonin Gene-Related Peptide - pharmacology</subject><subject>Calcitonin Gene-Related Peptide - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadotropin-Releasing Hormone - antagonists & inhibitors</subject><subject>Hindlimb</subject><subject>Hormone Antagonists - pharmacology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hot Flashes - physiopathology</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Injections, Intravenous</subject><subject>Islet Amyloid Polypeptide</subject><subject>Leuprolide - pharmacology</subject><subject>Male</subject><subject>Orchiectomy</subject><subject>Peptide Fragments - pharmacology</subject><subject>Peptides - administration & dosage</subject><subject>Peptides - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Calcitonin Gene-Related Peptide - drug effects</subject><subject>Skin Temperature - physiology</subject><subject>Testosterone - pharmacology</subject><subject>Vertebrates: endocrinology</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVIaFynPyFlLwntYVN9r3UKwbSNwZBDmrPQakdFza52K8mG_PvKH8THnmYYnndmeBC6JviOYCK_PWOscM2pEl8w-4qxWDS1OkMzImhplBLnaPaOXKKPKf3BGEspmw_oknBJuWJ0htwqbMd-CwOEXI2usqa3Po_Bh-o3BKgj9CZDV00wZd9BVebQw9ZkP4Ydn17LJMMwQTR5E_eANSnHfWowPVSlTVfowpk-wadjnaOXH99_LR_r9dPP1fJhXVumSK4bDKIFkA0FwZnpmDOybSSRxEHrKOWkldwKLrlSjjnackutaBzuOJEdw2yObg97pzj-3UDKevDJQt-bAOMm6YawxYKU3XMkDqCNY0oRnJ6iH0x80wTrnWC9F6x39jRmei9Yq5L7fDywaQfoTqmj0QLcHAGTikwXTbA-nThRMKqawt0fOCg6th6iTtZDsND5CDbrbvT_eeUfOhaY1w</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Yuzurihara, Mitsutoshi</creator><creator>Ikarashi, Yasushi</creator><creator>Noguchi, Masamichi</creator><creator>Kase, Yoshio</creator><creator>Takeda, Shuichi</creator><creator>Aburada, Masaki</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>Involvement of calcitonin gene-related peptide in elevation of skin temperature in castrated male rats</title><author>Yuzurihara, Mitsutoshi ; Ikarashi, Yasushi ; Noguchi, Masamichi ; Kase, Yoshio ; Takeda, Shuichi ; Aburada, Masaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-70e5bee672e543ad3fa6b76161febf2241b64c546499f3f2b4c2c57f0d416d303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adrenomedullin</topic><topic>Amyloid - administration & dosage</topic><topic>Amyloid - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcitonin Gene-Related Peptide - administration & dosage</topic><topic>Calcitonin Gene-Related Peptide - pharmacology</topic><topic>Calcitonin Gene-Related Peptide - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadotropin-Releasing Hormone - antagonists & inhibitors</topic><topic>Hindlimb</topic><topic>Hormone Antagonists - pharmacology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hot Flashes - physiopathology</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Injections, Intravenous</topic><topic>Islet Amyloid Polypeptide</topic><topic>Leuprolide - pharmacology</topic><topic>Male</topic><topic>Orchiectomy</topic><topic>Peptide Fragments - pharmacology</topic><topic>Peptides - administration & dosage</topic><topic>Peptides - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Calcitonin Gene-Related Peptide - drug effects</topic><topic>Skin Temperature - physiology</topic><topic>Testosterone - pharmacology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuzurihara, Mitsutoshi</creatorcontrib><creatorcontrib>Ikarashi, Yasushi</creatorcontrib><creatorcontrib>Noguchi, Masamichi</creatorcontrib><creatorcontrib>Kase, Yoshio</creatorcontrib><creatorcontrib>Takeda, Shuichi</creatorcontrib><creatorcontrib>Aburada, Masaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuzurihara, Mitsutoshi</au><au>Ikarashi, Yasushi</au><au>Noguchi, Masamichi</au><au>Kase, Yoshio</au><au>Takeda, Shuichi</au><au>Aburada, Masaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of calcitonin gene-related peptide in elevation of skin temperature in castrated male rats</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>62</volume><issue>5</issue><spage>947</spage><epage>951</epage><pages>947-951</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><coden>URGYAZ</coden><abstract>To assess the involvement of calcitonin gene-related peptide (CGRP) in the occurrence of hot flashes in men after castration for treatment of prostate cancer, we investigated the effects of CGRP on skin temperature in surgically and medically castrated male rats.
Changes in skin temperature of the hind paws after intravenous injection of 10 μg/kg of CGRP and CGRP family peptides (adrenomedullin and amylin) were measured at 5-minute intervals for 120 minutes, 3 weeks after bilateral orchiectomy or 2 weeks after subcutaneous injection of a gonadotropin-releasing hormone analogue (1.0 mg/kg Leuplin) in male rats. Antagonism with CGRP
8-37 (1000 μg/kg intravenously), a CGRP
1 receptor antagonist, to the CGRP-induced response was examined by injecting it 10 minutes before injection of CGRP. The effect of testosterone replacement on castration was evaluated in each castrated rat by the administration of testosterone (1.0 mg/kg subcutaneously once a day) for 14 days before the day of the temperature analysis.
CGRP, but not adrenomedullin and amylin, elevated the skin temperature in surgical or medical castration-induced testosterone-deficient rats more than in the sham-treated rats. The difference was statistically significant. The CGRP-induced potentiation in the castrated rats was inhibited by pretreating with CGRP
8-37 or by supplying testosterone.
CGRP is the most potent peptide in a family that elevates the skin temperature in male rats. The elevation of the skin temperature was more affected by the testosterone deficiency resulting from castration. These results suggest that CGRP is involved in the mechanism underlying hot flashes in men.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14624932</pmid><doi>10.1016/S0090-4295(03)00587-9</doi><tpages>5</tpages></addata></record> |
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| subjects | Adrenomedullin Amyloid - administration & dosage Amyloid - pharmacology Animals Biological and medical sciences Calcitonin Gene-Related Peptide - administration & dosage Calcitonin Gene-Related Peptide - pharmacology Calcitonin Gene-Related Peptide - physiology Fundamental and applied biological sciences. Psychology Gonadotropin-Releasing Hormone - antagonists & inhibitors Hindlimb Hormone Antagonists - pharmacology Hormones and neuropeptides. Regulation Hot Flashes - physiopathology Hypothalamus. Hypophysis. Epiphysis. Urophysis Injections, Intravenous Islet Amyloid Polypeptide Leuprolide - pharmacology Male Orchiectomy Peptide Fragments - pharmacology Peptides - administration & dosage Peptides - pharmacology Rats Rats, Sprague-Dawley Receptors, Calcitonin Gene-Related Peptide - drug effects Skin Temperature - physiology Testosterone - pharmacology Vertebrates: endocrinology |
| title | Involvement of calcitonin gene-related peptide in elevation of skin temperature in castrated male rats |
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