Internalization of OspA in rsCD14 complex and aggregated forms

Summary Although the spirochetal protein OspA is capable of stimulating immune cells in a CD14‐ and TLR2‐dependent manner, little is known about how TLR2 receptor complex ligands, such as OspA, are handled by the cell once delivered. We examine here the internalization of the fluorescently derivatiz...

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Veröffentlicht in:	Molecular microbiology 2003-11, Vol.50 (3), p.835-843
Hauptverfasser:	Welty, Diane M., Snyder, D. Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Chloro-7-nitrobenzofurazan - analogs & derivatives 4-Chloro-7-nitrobenzofurazan - metabolism Animals Antigens, Surface - drug effects Antigens, Surface - genetics Antigens, Surface - metabolism Bacterial Outer Membrane Proteins - drug effects Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Bacterial Vaccines Cells, Cultured Ceramides - metabolism Culture Media, Serum-Free - pharmacology Cytochalasin D - pharmacology Endothelial Cells - metabolism Golgi Apparatus - metabolism Lipopolysaccharide Receptors - genetics Lipopolysaccharide Receptors - metabolism Lipoproteins - genetics Lipoproteins - metabolism Lipoproteins, LDL - metabolism Lysosomes - metabolism Macrophages - metabolism Membrane Glycoproteins - metabolism Mice NF-kappa B - drug effects NF-kappa B - metabolism OspA protein Protein Transport Receptors, Cell Surface - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Toll-Like Receptor 2 Toll-Like Receptors Tumor Necrosis Factor-alpha - metabolism
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