Extended application of an LC–MS/MS method for the analysis of vesnarinone and its metabolites in human urine and dialysate fluid

Vesnarinone, a positive inotropic drug developed for congestive heart failure, and its metabolites (OPC-8230, OPC-18136, OPC-18137) were analyzed in human dialysate and urine (plus an additional metabolite: OPC-18692 in urine) samples using a modification to a previously published LC–MS/MS assay for...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2003-11, Vol.33 (4), p.711-717
Hauptverfasser:	Sekar, Kumara S, Bramer, Steven L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Dialysis Solutions - analysis Dialysis Solutions - metabolism Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry - methods General pharmacology Human dialysate Humans LC–MS/MS Medical sciences Metabolites Pharmacology. Drug treatments Precursor ion Product ion Quinolines - metabolism Quinolines - urine Vesnarinone
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